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Addison's Disease Message Board


Addison's Disease Board Index


You must feel awful!

If your doctor knew to take these tests, then hopefully he is good and can guide you well. Please post an update.

Because of the particular hormones with rock bottom numbers, you appear to be VERY low in [B][COLOR="Blue"]5-alpha reductase[/COLOR][/B] enzyme. Your DHT is also probably very low. There is a specific genetic disorder related to this (referred to as 5-alpha reductase deficiency in the links below), although your problem could be just adrenal fatigue that is manifesting itself this way.

Even if you do not fully have this particular genetic disorder, you are experiencing something similar, and the info on this disorder can help you with choosing treatment.

The 5-alpha reductase deficiency does not clearly explain why you have normal DHEA and low Testosterone. The DHEA could be converting to Estrogen (that is bad), or you could have Testosterone bound to SHBG which is not showing up in the test. If SHBG is high, you can take stinging nettle extract. If estrogen is high, you can take aromatase inhibitors, such as DIM or chrysin.

High Estrogen can cause high SHBG, which causes low free Testosterone (I think this is the only Testosterone to appear on the urine test). If you deterimine that Estrogen is high, you might want to supplement DHEA after fixing the Estrogen problem.

DHEA coverts to Androstenedione (via 3-beta-HSD enzyme). Then Androstenedione converts to Testosterone (via 17-beta-HSD enzyme). Either of the related enzymes could have a problem. This could explain why you have normal DHEA and low testosterone -- unless it is just an Estrogen issue.

:wave: If I were you, I would have tests done for the 3 main estrogens (Estradiol, Estriol, and Estrone), as well as SHBG and Androstenedione. You might also test Luteinizing Hormone (LH) and DHT.


[COLOR="Blue"][B]Now, for adrenals...[/B][/COLOR]

When the adrenals are fatigued, you can have hormone levels that do not make sense. The following info is based on my limited experience with treatment for one patient.

Some alternative doctors who specialize in rehabilitation of the adrenal glands will use [B][COLOR="Blue"]gradually [/COLOR][/B]higher doses of the following.
[LIST=1]
[*]Pantethine (900 mg to 1500 mg)
[*]Vitamin C (as Ascorbic Acid, 6 g to 10 mg)
[*]Vitamin C (as Magnesium Ascorbate, 500 mg)
[*]Vitamin C (as Calcium Ascorbate, 500 mg)
[*]Vitamin C (as Ascorbyl Palmitate, 1000 mg)
[*]Bioflavonoids (1000 mg to 1500 mg)
[*]Lysine (1000 mg)
[*]Proline (600 mg)
[/LIST]
The supplements listed above are taken in divided doses 2 or 3 times per day.

Then you can [COLOR="blue"][B]gradually [/B][/COLOR]introduce hormone supplements. Start with low dose (10 to 15 mg) Pregnenolone, since it is the highest up in the chain. You can then add DHEA along with the pregnenolone..

The progress should be gradual to prevent a relapse. If you suddenly feel super great, you should back off of the supplements and take it slow.

In your case, I would not supplement with Progesterone, because it inhibits 5-alpha reductase. Other people would likely add Progesterone.





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