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I am feeling really sick with lamactil even though I'm only taking 25 mg at night for four nights now. I still have to titrate upwards. Is this something that will improve with time, or am I headed towards a dead-end?

Linda
I felt very sick with lamactil right from the start and when I got up to the max dose of 200 I just stopped taking it, I also had severe buzzing in my head and terrible insommnia. I decided the illness was preferable. Sorry
I felt a little sick from the beginning. That may go away, but it can take a while.. What I would watch for is the rash. The rash can be more than bothersome, it can be serious, if you get it call your doc immediately (I got that, and had to be taken off).

Angie
I've been on Lamictal for a year-and-a-half now, and have never had any problems with it. As angie said, the most common side effect is rash, which in some cases can be very dangerous. As far as nausea, the information I have says that it happens to some people, but "is usually mild and limited to the early phase of treatment." I'm guessing, given JGREGG's experience, that "usually" means that some people have worse nausea, continuing nausea, or both. At any rate, I'm a huge advocate of Lamictal, as it has been very gentle on me and has worked very well, although it tends to work best for Bipolar Type II and rapid cycling, both of which apply to me. I'd give it a fair chance, and let your pdoc know about the nausea, then discontinue the Lamictal if it doesn't go away.
I took Neurontin for about a month and had to discontinue it because of multiple side-effects ("as advertised": drowsiness, aphasia, headaches and sore joints, even some tics)-- definitely wanted OFF of that! I'm ADD and my pdoc wanted to establish an anti-seizure med prior to a stimulant for the ADD, so put me on Lamictal 25 mg 2xda. It is more "gentle" as Grant said but it still makes me tired; I can tell because of sandy-feeling eyelids and a mild groggy feeling; so I tend not to take it except at bedtime-- pdoc says this is OK, that my reaction seems to be failrly common. Now I've started Wellbutrin, which has some beneficial affect on the ADD, but it seems like the effects I noted about Lamictal are accentuated; it's hard to tell. I tend to not want to take 2 ea of these, just 1 Wellbutrin in the morning and 1 Lamictal before bed. I am wondering about whether this is enough of either for beneficial effect but pdoc says everyone is different and perhaps this is what I can tolerate, and if it has beneficial effect on the ADD, well that might be the best thing. ?? Have to keep trying for awhile. I really tend to avoid the 2xda Lamictal, though; maybe it's because of my bad experience on Neurontin, which I understand is supposed to be similar psychopharmacologically, but for me was very different (much less gentle?) than Lamictal. Hope this helps.
[QUOTE=jjw3927]I took Neurontin for about a month and had to discontinue it because of multiple side-effects ("as advertised": drowsiness, aphasia, headaches and sore joints, even some tics)-- definitely wanted OFF of that! I'm ADD and my pdoc wanted to establish an anti-seizure med prior to a stimulant for the ADD, so put me on Lamictal 25 mg 2xda. It is more "gentle" as Grant said but it still makes me tired; I can tell because of sandy-feeling eyelids and a mild groggy feeling; so I tend not to take it except at bedtime-- pdoc says this is OK, that my reaction seems to be failrly common. Now I've started Wellbutrin, which has some beneficial affect on the ADD, but it seems like the effects I noted about Lamictal are accentuated; it's hard to tell. I tend to not want to take 2 ea of these, just 1 Wellbutrin in the morning and 1 Lamictal before bed. I am wondering about whether this is enough of either for beneficial effect but pdoc says everyone is different and perhaps this is what I can tolerate, and if it has beneficial effect on the ADD, well that might be the best thing. ?? Have to keep trying for awhile. I really tend to avoid the 2xda Lamictal, though; maybe it's because of my bad experience on Neurontin, which I understand is supposed to be similar psychopharmacologically, but for me was very different (much less gentle?) than Lamictal. Hope this helps.[/QUOTE]


Your experience just shows how different everyone's reaction to meds is. I had no side effects from neurontin, and got every single one, including the rash, from lamictal. Everyone's chemistry really is unique.

Angie
[QUOTE=jjw3927]I'm ADD and my pdoc wanted to establish an anti-seizure med prior to a stimulant for the ADD, so put me on Lamictal 25 mg 2xda. It is more "gentle" as Grant said but it still makes me tired... Now I've started Wellbutrin, which has some beneficial affect on the ADD, but it seems like the effects I noted about Lamictal are accentuated; it's hard to tell. I tend to not want to take 2 ea of these, just 1 Wellbutrin in the morning and 1 Lamictal before bed. I am wondering about whether this is enough of either for beneficial effect... I really tend to avoid the 2xda Lamictal, though...[/QUOTE]
jjw:

For reference in this post, here's my basic info to possibly help you with medication ratios and to give you a general idea of what has worked for me. I weigh 215 lbs and metabolize meds at a slightly above average rate. I am on 300mg Wellbutrin XL and 200mg Lamictal both of which I load in the morning. I also take 20 mg Adderol in the morning, 20 mg Adderol in the early afternoon, and 10 mg Adderol in the evening as needed. I am being treated for Bipolar Type II Rapid Cycling & ADHD.

I can't tell you whether the Lamictal makes me tired or whether the Wellbutrin accentuates this effect if it exists. I was on Depakote before the Lamictal, which left me physically exhausted, so I don't notice any tiredness from the Lamictal. This also may be due to the fact that I have been on Adderol for several years and as such have not experienced the Lamictal without it. I was on the Lamictal for three or four months before beginning Wellbutrin SR because although I was very stable, I was just bummed out all the time, perhaps as you said, due to the Lamictal. Apparently, Lamictal and Wellbutrin work well together; perhaps the Wellbutrin helps get rid of some of the downer effect of the Lamictal, as it is a stimulant. Like you, I hate taking pills twice a day because first I forget to take the afternoon dose, and second, taking twice a day makes me hate taking pills. Like you and Neurontin, it reminds me of my Lithium and Depakote days.

Thus, I load my Lamictal as well, although in the morning. While it is still usually suggested to take twice a day, the half-life of Lamictal is long enough that it is still effective when taken once a day. I recently switched to Wellbutrin XL when came out, because it works better for all-day than SR, which I was loading in the morning anyways. Finally, I take Adderol for ADHD, but it also helps with general fatigue and symptoms of narcolepsy, both of which I have suffered from my whole life. This may also prevent me from feeling any slow-down from the Lamictal. Anyhow, when I take the combination of the three, I feel better and more alive than I have for a long time. I'm leveled out, I can think clearly, I can feel my emotions, and I don't really notice the medication, other than feeling "butterflies in my head" if I miss a dose (similar to the effect of Zoloft).

Summing up, it sounds like your pdoc is setting you up with a similar coctail as the one I am on. If you're going to take the Lamictal once per day, I would recommend taking it in the morning, however, because although the half-life is long enough to sustain a theraputic blood level for 24 hours, I think it is better to have the highest blood levels during the day when I have to deal with people and such. I'm not sure about the Wellbutrin as enhancing any downer effect from the Lamictal, but then again, everyone's body chemistry is different. They work well together for me, with the Lamictal stabilizing long-term and the Wellbutrin maintaining daily mood. Finally, I think you'll find this to be an excellent combination, especially once you get established on a stimulant, which may be the factor for me that makes the Lamictal unnoticable. Sorry to wear out your eyes; I hope some of this helps.
Grant,

Thanks for replying and explaining the various factors involved. It seems like there's alot of similarity-- Dx/Rx/effects. But you've obviously alot more experience than I and there's apparently differences, too, as you and others know and have remarked about. It seems to me kind of like doing a jigsaw puzzle where some pieces can morph along the way: you know alot about how it (the process) will go and what it will probably look like when its done, but there's "discovery" along the way that changes some of the pieces you thought were there and even the outcome of the puzzle and the route.
One thing I'm wondering about now is that because I seem to be reacting to relatively minimum doses, whether there's a "baseline", so to speak, that has to be maintained as well as spreading the meds effect over the day. It seems like there's quite a difference in dose/da range, and different reactions. For example, you seem to focus on the morning/day and so do I, but I don't seem to have the same reaction to Lamictal in the morning, so I seem to avoid it then-- but the Wellbutrin reaction seems similar, though I don't seem to feel like I need it in and past the afternoon, so think maybe I don't need the 2nd one/da. Is that "inbounds", so to speak, do you think? Like I said, being a sort of organic puzzle, maybe it is and maybe it isn't, you just have to keep proceeding, adjusting as you go (or not!), based on how the puzzles'working out.
By the way, I also get some ear ringing, too, from the Wellbutrin but then it seems to dissipate after awhile (hour+, ++); I've read about that reaction from some others talking about it.
Again, thanks for your consideration and help.
I've been on a combination of Seroquel,Lamictal,and Wellbutrin. I take 200mg of Lamictal (which is rather high)along with Seroquel before bed. It does make me very tired-but other than that-it's ok. In the beginning however, it did make me sick to my stomach and some headaches-but that disapeared after a couple of weeks. I had to switch to Lamictal from Depakote because I had a horrible reaction to it-ringing in my ears, shaking vision and on an on. So, all and all I agree that the Lamictal is much more gentle. It's just a differnt point of view-I hope it helps





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