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If your Lupus is in remission, a negative result can occur. You can even still have Lupus without ever having a positive ANA. Clinical symptoms need to be there, I'm sure. Are you on any treatment (medications) that could make it go in remission? like Plaquenil, anti-inflammatory?

I had a negative ANA one time after many positive one's and had a dx of mild Lupus, but my general practicioner said because of that one test, I did not have an autoimmune disease and I quit going to a rhematologist. He also dx'd depression, fibromyalgia. Well I went many years without it checked and just went to a lab and checked it myself, and my ANA wasn't just positive, the autoantibody to a disease showed up (for MCTD), I had it rechecked at a different lab after they treated me for a mth on medications and that autoantibody decreased by half.

Another dr recommended me doing that, not my primary care doctor. This one said having it repeated at a different lab can prove the significance of the results. I would recommend you have yours rechecked in a couple of months.

Believing I didn't have an AI disease was the BIGGEST mistake I have ever made. I have done nothing but live in misery with this illness because of lack of treatment for it.

I wouldn't feel like I hate life so if it wasn't for feeling the way I do. I didn't get depression until 4 years after I got sick. When they treated it mths back, my mood got so much better, but when they took the medication (because of my ulcer), I pretty much had a nervous breakdown. I couldn't handle feeling better and then crashing back down and my family giving me hell because of.
I can't say Quest wasn't appropriate with their testing. I don't know. But there can be false negatives that occur in ANA testing. I would just have it rechecked again to be sure of the results. My guess would be that your Lupus may be in remission. Lab Corp is the lab I go to, but I have to use a different lab online in ordering the test. I can get it done for around $60 without using my insurance, but it only shows if the ANA is positive or negative, and if you have an autoantibody present, it will show how high that is. Some labs charge $500 for the ANA Panel, I really don't know why one is so expensive and others aren't. Maybe the one so high tests all autoantibodies. The one I have done tests for things like this: (I'll share my results):
ANA w/Reflex
ANA Direct Positive Abnormal -- Reference Range: Negative
Anti−DNA (DS) Ab Qn 1 IU/mL -- Ref Range 0-9
Negative <5
Equivocal 5 − 9
Positive >9
RNP Antibodies 7.3 High -- Ref Range 0.0 − 0.9
Smith Antibodies <0.2 Sjogren's Anti−SS−A <0.2 -- Ref Range 0.0 − 0.9
Sjogren's Anti−SS−B <0.2 -- Ref Range 0.0 − 0.9
ANA Direct Positive Abnormal
RNP Antibodies 7.3 High

You should be able to use your insurance at a different lab (if not - ouch), I can go to any lab I want with my insurance.

I took Plaquenil back in 2002. It alone did not phase me in how I felt. Mobic pretty much gave me some of my energy back and made me feel better. And I took an anti-malarial antibiotic with it part of the time. Does he have you on an anti-inflammatory medication too? Maybe Plaquenil just isn't enough to help you feel better. I think Rheumatologists pretty much give you prednisone during bad flares, don't they? My Rhemy never did try me on that.

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