... Amanda, ANA isn't the sum of specific AB's. It's a threshold test and a general one. ... (1 replies)
... specific rash. A strongly positive ANA would raise a red flag. ... (3 replies)
... Rebeccajane, just want to say hi and welcome. I saw recent news articles suggesting that anti-chromatin AB is now being viewed as a significant finding in lupus with kidney involvement. This "take" looks recent to me.
You can view the criteria "most used" to diagnose SLE in one of the sticky posts (permanent info posts) located above the thread list. In those, the... (9 replies)
... Hello, I'm familiar with all you've just spoke about and believe you yourself have come to a reasonable possible diagnosis. I personally think because of rash on toes and other places with all your other symptoms that although rare Polymyositis or Detmatomyositis should be concidered. You've already shown to have some of the positive test results for this disease. There's a... (34 replies)
... Maddy, hi & welcome. I'm sorry to read about your issues, not fun. (I had problems from early adolescence myself.) One of the best things you could do: visit your library for one or more of the popular lupus hardcovers. Then just browse the sections that seem pertinent. (You don't need to read every line.) Have you seen the "sticky posts"? Those are the permanent info posts... (5 replies)
... C4 levels up into the normal range after I started taking it. ... (2 replies)
... Hi & welcome. I think the antibody tests are often parsed into ranges confusing to newcomers. (They were to me, anyway!) Sometimes you'll see ranges for "negative", for "low-positive", "positive", and "high-positive". I suspect that doctors generally hold off on looking for lupus if ANA is in the negative range, unless symptoms & other labs very strongly point that way.
But... (1 replies)
... Hi & welcome. Is "PFO" a hole between the upper chambers of your heart (not sure I know this term)?
Do you have a name for your chronic kidney problem, and what lab results you've seen because of it (just curious)?
I have lupus. I've had low Vitamin D, which probably started before my dx, then fell precipitously after I began avoiding sun. I take a daily supplement and... (1 replies)
... 2 years ago the rheumy checked the TSH and the TPO ( they were ok ) but the neurologist this time checked the TSH only ( the order said: TSH with reflex to free T4 if abnormal ) but the TSH was ok.
What is a HLA - B27 ? ( reference range : negative ) and my was negativ, 2 years ago. Also back then Immunoglobulin G serum was a little high , 1671 ( 700-1600 ), but the rheumy... (28 replies)
... That's good to know. I am not familiar with all the different testing methods available, so I'll keep that in mind. I was blown away when I saw >400 results on a friend when mine runs in the 20-30 range! Thanks for the additional info. (28 replies)
... Many people with lupus have low B12 counts. Your lab uses an unusually low cut off for low end of range, as it is normally 400-1000. There are lots of reasons why B12 can be low, but it usually has to do with absorption (lack of), seen in pernicious anemia, celiac disease and other malabsorption states. If you take B12 orally and your count doesn't come up, it indicates you... (28 replies)
... What about the vit b12 level ? 2 years ago( actually 2 and a half ) was 259 and now it's 244 ( out of 211-911 range ). The rheumy didn't even mention it as low, now the neurologist say it's kind a low. So is it a "good" sign that actually it didn't go really lower since then ? ( I know that people have problems even with higher numbers ) So how can I know the b12 is a problem ? (28 replies)
... I have no recent titer on ANA, my labs just flag ana positive if any of the other antibodies are positive. ... (28 replies)
... logist for the dizziness, I didn't even think it could be lupus releated, because two years ago I didn't get diagnosed with it, but I told the dr. to recheck the ANA , so she did that with the b12 and vit. d. ... (28 replies)
... DNA, labs vary, so you'd need the range your lab uses. ... (28 replies)
... I understand your disgust. So I hate saying this, but rheum's approach seems by-the-book and "correct" to me, especially since your last RF was still in the negative range... and I can't even guess about your previous ANA & anti-DNA (you didn't state those). For lupus, rheums do need to see a certain number of findings, per the established ACR criteria. (You may find those in... (7 replies)
... Based on that, I still suspect that it's possible that a reading of 13 could be a tiny bit elevated yet nowhere near the range that worries most rheums. For example, the author of one book only really worries at a certain level. ... (4 replies)
... Welcome KM to the boards. I think we can help you. You do have several symptoms suggestive of lupus, plus two tests that support the diagnosis. 19 is not very high on the dsDNA, and many people with lupus have low numbers like this and do not have kidney involvement. This level fluctuates some, but for reference sake, some people have anti-dsDNA in the 100-400 range when they... (3 replies)
... Once ANA is positive, rheums run tests for specific autoantibodies called "ANA subtypes". ... (7 replies)
... ANA Screen IFA POSITIVE
ANA Pattern 1 HOMOGENEOUS
ANA Titer 1 1:40
Reference Range <1:40 Negative
1:40-1:80 Low Antibody Level
>1:80 Elevated Antibody Level
My PCP ran blood work on me b/c of my symptoms. This is what we got back. I am going to my first rheumatologist appointment tomorrow. Just wondering what all this means. Any insight would be greatly... (4 replies)