... The problem with ANA is that it's not specific to any one condition. ... (9 replies)
... I had the ANA with reflex cascade, so after the first series of 5 antibodies found a positive, the test stopped. ... (7 replies)
... I think direct immunofluorescence refers to one method of autoimmune blood labs.
While I do think testing for Celiac* makes sense, the fact that you've had positive results on *multiple* ANA subtypes that are *all* possible in lupus---anti-Ro, anti-La, anti-Sm, and anti-RNP---seems really important. Do you know how high those were---meaning their actual readings for each,... (14 replies)
... As for blood work, I have had the CBC done, and while my RBC are within the range 4. ... (11 replies)
... to me your other labs look within reference range on this set of labs. ... (7 replies)
... Hi & welcome! I'm sorry for your problems but I'm glad you found us. I'll start with ANA: it's not diagnostic of anything and can be positive in a wide variety of conditions. Also, level matters from what one reads: a low level of, say, 1:80, isn't going to raise eyebrows (a level that low can even be due to a passing bacterial or viral infection), but a high level like 1:640... (3 replies)
... Lisa, hello & welcome. I'm sorry you've been struggling with all this. (Also sorry for not writing sooner, I had a wicked bad month with my computer.) Best place to start is one of the "sticky posts"; those are the permanent info posts located about the user threads. Look at the one with diagnostic criteria. Generally, but NOT always, a patient must meet 4 or more to sustain a... (14 replies)
... Amanda, ANA isn't the sum of specific AB's. It's a threshold test and a general one. ... (1 replies)
... Hi & welcome. Is "PFO" a hole between the upper chambers of your heart (not sure I know this term)?
Do you have a name for your chronic kidney problem, and what lab results you've seen because of it (just curious)?
I have lupus. I've had low Vitamin D, which probably started before my dx, then fell precipitously after I began avoiding sun. I take a daily supplement and... (1 replies)
... 2 years ago the rheumy checked the TSH and the TPO ( they were ok ) but the neurologist this time checked the TSH only ( the order said: TSH with reflex to free T4 if abnormal ) but the TSH was ok.
What is a HLA - B27 ? ( reference range : negative ) and my was negativ, 2 years ago. Also back then Immunoglobulin G serum was a little high , 1671 ( 700-1600 ), but the rheumy... (28 replies)
... That's good to know. I am not familiar with all the different testing methods available, so I'll keep that in mind. I was blown away when I saw >400 results on a friend when mine runs in the 20-30 range! Thanks for the additional info. (28 replies)
... Many people with lupus have low B12 counts. Your lab uses an unusually low cut off for low end of range, as it is normally 400-1000. There are lots of reasons why B12 can be low, but it usually has to do with absorption (lack of), seen in pernicious anemia, celiac disease and other malabsorption states. If you take B12 orally and your count doesn't come up, it indicates you... (28 replies)
... What about the vit b12 level ? 2 years ago( actually 2 and a half ) was 259 and now it's 244 ( out of 211-911 range ). The rheumy didn't even mention it as low, now the neurologist say it's kind a low. So is it a "good" sign that actually it didn't go really lower since then ? ( I know that people have problems even with higher numbers ) So how can I know the b12 is a problem ? (28 replies)
... I have no recent titer on ANA, my labs just flag ana positive if any of the other antibodies are positive. ... (28 replies)
... logist for the dizziness, I didn't even think it could be lupus releated, because two years ago I didn't get diagnosed with it, but I told the dr. to recheck the ANA , so she did that with the b12 and vit. d. ... (28 replies)
... DNA, labs vary, so you'd need the range your lab uses. ... (28 replies)
... I understand your disgust. So I hate saying this, but rheum's approach seems by-the-book and "correct" to me, especially since your last RF was still in the negative range... and I can't even guess about your previous ANA & anti-DNA (you didn't state those). For lupus, rheums do need to see a certain number of findings, per the established ACR criteria. (You may find those in... (7 replies)
... Based on that, I still suspect that it's possible that a reading of 13 could be a tiny bit elevated yet nowhere near the range that worries most rheums. For example, the author of one book only really worries at a certain level. ... (4 replies)
... Welcome KM to the boards. I think we can help you. You do have several symptoms suggestive of lupus, plus two tests that support the diagnosis. 19 is not very high on the dsDNA, and many people with lupus have low numbers like this and do not have kidney involvement. This level fluctuates some, but for reference sake, some people have anti-dsDNA in the 100-400 range when they... (3 replies)
... Once ANA is positive, rheums run tests for specific autoantibodies called "ANA subtypes". ... (7 replies)