... Melissa, very *high* anti-ds-DNA points strongly to lupus, but *slight* elevations are possible in some other conditions. In fact, a very high finding would fulfill one of the 11 ACR criteria. But without the reference range, it's impossible to tell how high yours is; so when you discuss your findings with your doctor, you should ask for the range & ask how high he/she deems... (5 replies)
... Hi. I'm merely a patient, so please read in that light. First, a quick question: is your doctor a rheumatologist? If NO, I'd want one, for the reasons below. If YES, I'd try a new rheum.
First, I believe that at least two of your labs, elevated ANA and depressed serum complements C3 & C4, are both cited in the 11 diagnostic/classification criteria for SLE. You can read all... (1 replies)
... Is it normal that a specialist ( my neurologist ) doesn't call back even after I called her office for a test result ( autonomic test ) ? I have these other problems since I saw her and I was ready to discuss them with her when she calls, but I'm looking for a new neurologist right now (she missed my anti ds-Dna being 22 anyway on my blood work, and if I hadn't ask for a copy... (28 replies)
... Sparkle, hi & welcome. The first thing that strikes me is back pain going into your extremities, causing muscle spasms. I don't really associate those problems with fibromyalgia, so I'm curious what the others think on that point. (Made me wonder about disc compression, tingling due to vitamin/mineral deficiencies or diabetes, etc.)
Because you're taking Tramadol and... (4 replies)
... Hmmm... If these were SCLE lesions, I'd expect UV rays to make them worse, not better, meaning more to arise fairly shortly after a UV treatment. I'm trying to remember how long after exposure to natural sunlight my lesions appeared. Not immediately, maybe 1-2 days. Can't quite remember, sorry. In short, I don't know whether these could be SCLE lesions, but it does seem worth... (73 replies)
... of autoantibody tests run depends on which "panel" was requested by your doctor. If you care to share those test names, people here might be able to comment further. ... (9 replies)
... I have an appt. to get a second opinion for my infertility next month and I will bring all this up with him as well. Hopefully he'll agree to test me for the antiphospholipid antibody syndrome. Is this just 1 blood test? ... (6 replies)
... Lori, Where lupus is a possibility, I think elevated B.U.N. and creatine in bloodwork are signs kidneys aren't filtering properly. (I just reread your original post & realized you said those values were NOT QUITE out of range.) And urinalysis includes checks for "urine casts" and for protein in the urine, which are also signs of abnormal kidney function.
Have they... (6 replies)
... DNA with a negative ANA. Just to note, you can still have children if you have APLS, they don't all end in miscarriages. A miscarriage is just a red flag to test for this. I never understood why people who miscarry, aren't automatically tested for this. ... (6 replies)
... DNA is just one test that is specific for lupus. Although yours is a low positive, the number may change over the next few years and it should definitely be watched. ... (6 replies)
... My dr. had said all my tests were fine. The ANA screen came back negative though. Should I inquire about the Anti DS DNA? ... (6 replies)
... I remember having a blood test done a while ago when I was being worked up for something else, and the test said something about being positive for anti ds-DNA ase, and I know this is an antinuclear antibody, but does it mean that I'm going to get lupus at some time in my life? Or does it just mean that I had inflammation or something? My aunt has lupus, scleroderma, and... (1 replies)
... Hi. Do you have hardcopy of the labs, or were results read over the phone? My lab prints out-of-range vs. in-range values in separate columns.
For anti-ds-DNA, my lab uses these ranges, BUT there's no guarantee your lab uses the same. For something this important, I'd ask the doctor for hardcopy.
< 25, Negative;
35-99.9, Weakly Positive;
100-200,... (2 replies)
... DNA test was done. ... (3 replies)
... Hi. Apparently anti-ds-DNA can vacillate: it can be higher just before, or at the start of, flares; and once it turns positive, it stays positive. I don't know that it's a titer test, though (sorry), you'd have to ask. Unfortunately, if the reference range on the report says >10 is positive, then >20 appears to be solidly positive, but you should confirm with someone familiar... (3 replies)
... your test results. ... (3 replies)
... Thanks for your input VeeJ. The followup with my GP is open. It's pretty much up to me. I can see him on fairly short notice. Since I posted my message I have done some reading and I see that many rheumie's diagnose a patient with Lupus based solely on the anti-ds-DNA. Makes sense if it is very selective and it is so hard to make a diagnosis otherwise anyway. I'll discuss this... (3 replies)
... if he didn't run that test yet. I hope you keep posting here. Keep at it! ... (3 replies)
... Destiny, hi.
Your first question: I think there are two different measuring systems for ANA. (1) The first is a simple ratio, like the 1:40 you mentioned. I *think* some experts consider 1:30 (and above) to be high. (2) In the second measuring system, the number doubles for each dilution. Examples: 1:80, 1:160, 1:320, 1:640, 1:1280, etc. I *think* some experts... (3 replies)
... and my Anti DS DNA result was positive, no number was listed. ... (3 replies)