... m AB. While it's good that this is negative, unfortunately there are multiple antibody screens available, so it's impossible to know which specific AB's this one test includes, i.e., it may not be exhaustive. ... (1 replies)
... We have the results of the latest tests and here I am with many questions again! Compared to 4-6 weeks ago, ESR (67), CRP (1.8) and anti-RNP (4.8) stayed the same and as high as before, anti-ds-DNA (IFA) went up even higher to 34 compared to 20 (ref. 0-4) , and the rest were normal/negative (RF, anti-CCP, anti-thyroglobulin, anti-cardiolipin, and G6PD). Urinalysis showed a... (35 replies)
... Hi and welcome! I'm just a patient, so please read in that light.
Re: ANA pattern. I think these are taken with a big grain of salt because they're assigned by a lab tech & thus are subjective. I think nucleolar also correlates with polymyositis (in addition to scleroderma and CREST).
It is possible to have lupus with AB's other than anti-ds-DNA and anti-Smith. The... (5 replies)
... p.s. I got a copy of the urine test that was done last month and it says complete urinalysis, so it was not by dipstick. ... (35 replies)
... DNA which made me think that maybe kidney is already involved. Hopefully rheumy will order another urinalysis to also include test for cast so that we know better what is going on. ... (35 replies)
... Complement, SLE is dx'ed using 11 "classification criteria" pre-established by the American College of Rheumatology (ACR). You may find them in the "sticky posts" (permanent info posts)*, located above the user threads. Generally (but not always) you must meet 4 or more of the 11 for a dx of systemic lupus. They need not present simultaneously, btw; instead, envision checking... (35 replies)
... then diagnosis of lupus is kind of certain. In terms of rheumys accepting only special labs to do the testing, I thought the test already done by the PCP would be acceptable because both of them are in the same medical complex and would probably use the same lab, but maybe not? ... (35 replies)
... I have an appt. to get a second opinion for my infertility next month and I will bring all this up with him as well. Hopefully he'll agree to test me for the antiphospholipid antibody syndrome. Is this just 1 blood test? ... (6 replies)
... Lori, Where lupus is a possibility, I think elevated B.U.N. and creatine in bloodwork are signs kidneys aren't filtering properly. (I just reread your original post & realized you said those values were NOT QUITE out of range.) And urinalysis includes checks for "urine casts" and for protein in the urine, which are also signs of abnormal kidney function.
Have they... (6 replies)
... DNA with a negative ANA. Just to note, you can still have children if you have APLS, they don't all end in miscarriages. A miscarriage is just a red flag to test for this. I never understood why people who miscarry, aren't automatically tested for this. ... (6 replies)
... DNA is just one test that is specific for lupus. Although yours is a low positive, the number may change over the next few years and it should definitely be watched. ... (6 replies)
... My dr. had said all my tests were fine. The ANA screen came back negative though. Should I inquire about the Anti DS DNA? ... (6 replies)
... I remember having a blood test done a while ago when I was being worked up for something else, and the test said something about being positive for anti ds-DNA ase, and I know this is an antinuclear antibody, but does it mean that I'm going to get lupus at some time in my life? Or does it just mean that I had inflammation or something? My aunt has lupus, scleroderma, and... (1 replies)
... Hi. Do you have hardcopy of the labs, or were results read over the phone? My lab prints out-of-range vs. in-range values in separate columns.
For anti-ds-DNA, my lab uses these ranges, BUT there's no guarantee your lab uses the same. For something this important, I'd ask the doctor for hardcopy.
< 25, Negative;
35-99.9, Weakly Positive;
100-200,... (2 replies)
... DNA test was done. ... (3 replies)
... Hi. Apparently anti-ds-DNA can vacillate: it can be higher just before, or at the start of, flares; and once it turns positive, it stays positive. I don't know that it's a titer test, though (sorry), you'd have to ask. Unfortunately, if the reference range on the report says >10 is positive, then >20 appears to be solidly positive, but you should confirm with someone familiar... (3 replies)
... your test results. ... (3 replies)
... Thanks for your input VeeJ. The followup with my GP is open. It's pretty much up to me. I can see him on fairly short notice. Since I posted my message I have done some reading and I see that many rheumie's diagnose a patient with Lupus based solely on the anti-ds-DNA. Makes sense if it is very selective and it is so hard to make a diagnosis otherwise anyway. I'll discuss this... (3 replies)
... if he didn't run that test yet. I hope you keep posting here. Keep at it! ... (3 replies)
... Destiny, hi.
Your first question: I think there are two different measuring systems for ANA. (1) The first is a simple ratio, like the 1:40 you mentioned. I *think* some experts consider 1:30 (and above) to be high. (2) In the second measuring system, the number doubles for each dilution. Examples: 1:80, 1:160, 1:320, 1:640, 1:1280, etc. I *think* some experts... (3 replies)