... Good morning. This sounds very frustrating, as many of us here have likewise experienced...! Have you read the diagnostic criteria for lupus? You may find the 11 in one of the "sticky posts" above the user threads. Generally, but not always, you must meet at least 4 to sustain a diagnosis of SLE. They should be considered "permanent", i.e., envision checking each off, once... (2 replies)
... if you can get actual copies of your test results, and care to post them here, it would be helpful. ... (2 replies)
... dsDNA test. In March, a negative ANA, no other test conducted. Fast forward to this week, negative ANA test but positive anti dsdna test. ... (2 replies)
... CCP is a test for early RA. ... (4 replies)
... My point is, she didn't even test for the most logical "differentials"! Again, one of those hardcovers would be useful. ... (11 replies)
... Hi & welcome. While I have read that ANA can be positive in "just Hashimoto's", because yours has been this high---1:1280 and 1:640---AND you have some interesting symptoms going on, I'd want several things:
New basic labs. CBC can turn up oddities in people with AI's. These aren't diagnostic per se.
New tests for ANA "subtypes". ANA alone can't diagnose anything---you... (11 replies)
... CCP, a test for early Rheumatoid Arthritis. ... (7 replies)
... may or may not perform well with tumid lupus. It's a specialty test that requires special skills to perform. ... (7 replies)
... Hi and welcome. Glad you found us. I've read articles about the challenges of differentiating APS lupus (lupus with antiphospholipid syndrome), CNS lupus (lupus with central nervous system involvement), and MS. To be honest, I'd never known that MS can cause, at least early on, a positive ANA in 1/4 or more of MS patients. Researchers may have studied whether ANA in MS stays... (7 replies)
... Maddy, hi and welcome. I'm sorry for your issues and for your not having answers. A lot of us---maybe most---spent time in limbo. Have you read the "sticky posts" (permanent info posts) above the user threads? The core of a lupus dx is explained in the "sticky" about criteria. Generally (but not always), you must meet 4 or more of the 11 to sustain a dx of SLE.
Re ANA. I... (4 replies)
... Hello & welcome. I am so NOT a doctor, so please read in that light. Although the results that ARE available (more on that in a bit) make one think of lupus, what I don't know---just as you said too---is how high your anti-dsDNA really is and what its "Crithidia titer" of 1:40 means.
When I first suspected I had lupus, I thought ANY positive anti-ds-DNA was very meaningful... (8 replies)
... patient, but I believe ANA is a very general test that can be positive in quite a few conditions, and that it's never by itself alone diagnostic of anything. ... (1 replies)
... Lisa, hello & welcome. I'm sorry you've been struggling with all this. (Also sorry for not writing sooner, I had a wicked bad month with my computer.) Best place to start is one of the "sticky posts"; those are the permanent info posts located about the user threads. Look at the one with diagnostic criteria. Generally, but NOT always, a patient must meet 4 or more to sustain a... (14 replies)
... I have an appt. to get a second opinion for my infertility next month and I will bring all this up with him as well. Hopefully he'll agree to test me for the antiphospholipid antibody syndrome. Is this just 1 blood test? ... (6 replies)
... Lori, Where lupus is a possibility, I think elevated B.U.N. and creatine in bloodwork are signs kidneys aren't filtering properly. (I just reread your original post & realized you said those values were NOT QUITE out of range.) And urinalysis includes checks for "urine casts" and for protein in the urine, which are also signs of abnormal kidney function.
Have they... (6 replies)
... DNA with a negative ANA. Just to note, you can still have children if you have APLS, they don't all end in miscarriages. A miscarriage is just a red flag to test for this. I never understood why people who miscarry, aren't automatically tested for this. ... (6 replies)
... DNA is just one test that is specific for lupus. Although yours is a low positive, the number may change over the next few years and it should definitely be watched. ... (6 replies)
... My dr. had said all my tests were fine. The ANA screen came back negative though. Should I inquire about the Anti DS DNA? ... (6 replies)
... I remember having a blood test done a while ago when I was being worked up for something else, and the test said something about being positive for anti ds-DNA ase, and I know this is an antinuclear antibody, but does it mean that I'm going to get lupus at some time in my life? Or does it just mean that I had inflammation or something? My aunt has lupus, scleroderma, and... (1 replies)
... Melissa, very *high* anti-ds-DNA points strongly to lupus, but *slight* elevations are possible in some other conditions. In fact, a very high finding would fulfill one of the 11 ACR criteria. But without the reference range, it's impossible to tell how high yours is; so when you discuss your findings with your doctor, you should ask for the range & ask how high he/she deems... (5 replies)