... Hi & welcome. This has to be frustrating. First, I have to say that I don't know the reference ranges for the AVISE tests, meaning how high your anti-ds-DNA of 302 is; and I'm not sure to which test the "38" refers: is it ANA? Maybe you could get the reference ranges & maybe others who know more about AVISE will weigh in.
Lupus is usually diagnosed using the ACR (American... (1 replies)
... But the most definitive test is lip biopsy. ... (6 replies)
... Hi. If this *is* lupus, I think anti-ds-DNA is one of the autoantibodies that it "pays" to retest since it's one that indicates disease severity & thus is considered "clinically significant". And I really wonder if the typical ER even runs it since it's a specialty test. I don't mean any disrespect to ER doctors, but they're best at trauma, heart attacks, strokes, etc. So if I... (6 replies)
... Zoe, I just read myself that certain meds can cause lymphocytopenia (low lymphocytes), but I think some of the inflammatory AI's themselves can as well, like lupus & RA, and maybe more.
Re RF, I don't know what level is considered "interesting". I think doctors often run a more useful test called anti-CCP (anti-cyclic citrullinated protein).
I'd also wonder if the... (21 replies)
... Hi & welcome. I'm sorry for your problems. I'm wondering if you could be in somewhat of a gray area. Have you read the "sticky posts" (permanent info posts) located above the user threads? I'm about to cite them... Here goes:
While you may have met several of the ACR criteria, you may not have met enough to be a clear-cut case of "classic" systemic lupus. Generally, but not... (6 replies)
... I have an appt. to get a second opinion for my infertility next month and I will bring all this up with him as well. Hopefully he'll agree to test me for the antiphospholipid antibody syndrome. Is this just 1 blood test? ... (6 replies)
... Lori, Where lupus is a possibility, I think elevated B.U.N. and creatine in bloodwork are signs kidneys aren't filtering properly. (I just reread your original post & realized you said those values were NOT QUITE out of range.) And urinalysis includes checks for "urine casts" and for protein in the urine, which are also signs of abnormal kidney function.
Have they... (6 replies)
... DNA with a negative ANA. Just to note, you can still have children if you have APLS, they don't all end in miscarriages. A miscarriage is just a red flag to test for this. I never understood why people who miscarry, aren't automatically tested for this. ... (6 replies)
... DNA is just one test that is specific for lupus. Although yours is a low positive, the number may change over the next few years and it should definitely be watched. ... (6 replies)
... My dr. had said all my tests were fine. The ANA screen came back negative though. Should I inquire about the Anti DS DNA? ... (6 replies)
... I remember having a blood test done a while ago when I was being worked up for something else, and the test said something about being positive for anti ds-DNA ase, and I know this is an antinuclear antibody, but does it mean that I'm going to get lupus at some time in my life? Or does it just mean that I had inflammation or something? My aunt has lupus, scleroderma, and... (1 replies)
... Melissa, very *high* anti-ds-DNA points strongly to lupus, but *slight* elevations are possible in some other conditions. In fact, a very high finding would fulfill one of the 11 ACR criteria. But without the reference range, it's impossible to tell how high yours is; so when you discuss your findings with your doctor, you should ask for the range & ask how high he/she deems... (5 replies)
... Hi. Do you have hardcopy of the labs, or were results read over the phone? My lab prints out-of-range vs. in-range values in separate columns.
For anti-ds-DNA, my lab uses these ranges, BUT there's no guarantee your lab uses the same. For something this important, I'd ask the doctor for hardcopy.
< 25, Negative;
35-99.9, Weakly Positive;
100-200,... (2 replies)
... DNA test was done. ... (3 replies)
... Hi. Apparently anti-ds-DNA can vacillate: it can be higher just before, or at the start of, flares; and once it turns positive, it stays positive. I don't know that it's a titer test, though (sorry), you'd have to ask. Unfortunately, if the reference range on the report says >10 is positive, then >20 appears to be solidly positive, but you should confirm with someone familiar... (3 replies)
... your test results. ... (3 replies)
... Thanks for your input VeeJ. The followup with my GP is open. It's pretty much up to me. I can see him on fairly short notice. Since I posted my message I have done some reading and I see that many rheumie's diagnose a patient with Lupus based solely on the anti-ds-DNA. Makes sense if it is very selective and it is so hard to make a diagnosis otherwise anyway. I'll discuss this... (3 replies)
... if he didn't run that test yet. I hope you keep posting here. Keep at it! ... (3 replies)
... Destiny, hi.
Your first question: I think there are two different measuring systems for ANA. (1) The first is a simple ratio, like the 1:40 you mentioned. I *think* some experts consider 1:30 (and above) to be high. (2) In the second measuring system, the number doubles for each dilution. Examples: 1:80, 1:160, 1:320, 1:640, 1:1280, etc. I *think* some experts... (3 replies)
... and my Anti DS DNA result was positive, no number was listed. ... (3 replies)