... may or may not perform well with tumid lupus. It's a specialty test that requires special skills to perform. ... (4 replies)
... Hi and welcome. Glad you found us. I've read articles about the challenges of differentiating APS lupus (lupus with antiphospholipid syndrome), CNS lupus (lupus with central nervous system involvement), and MS. To be honest, I'd never known that MS can cause, at least early on, a positive ANA in 1/4 or more of MS patients. Researchers may have studied whether ANA in MS stays... (4 replies)
... Maddy, hi and welcome. I'm sorry for your issues and for your not having answers. A lot of us---maybe most---spent time in limbo. Have you read the "sticky posts" (permanent info posts) above the user threads? The core of a lupus dx is explained in the "sticky" about criteria. Generally (but not always), you must meet 4 or more of the 11 to sustain a dx of SLE.
Re ANA. I... (4 replies)
... Hello & welcome. I am so NOT a doctor, so please read in that light. Although the results that ARE available (more on that in a bit) make one think of lupus, what I don't know---just as you said too---is how high your anti-dsDNA really is and what its "Crithidia titer" of 1:40 means.
When I first suspected I had lupus, I thought ANY positive anti-ds-DNA was very meaningful... (7 replies)
... patient, but I believe ANA is a very general test that can be positive in quite a few conditions, and that it's never by itself alone diagnostic of anything. ... (1 replies)
... Lisa, hello & welcome. I'm sorry you've been struggling with all this. (Also sorry for not writing sooner, I had a wicked bad month with my computer.) Best place to start is one of the "sticky posts"; those are the permanent info posts located about the user threads. Look at the one with diagnostic criteria. Generally, but NOT always, a patient must meet 4 or more to sustain a... (11 replies)
... Hi & welcome! Lupus actually has a very wide age continuum, and even things deemed "rare" can happen. I myself was dx'ed in late 40's with a "rare" subset in which my ANA was negative but anti-Ro was positive. I'd had problems since adolescence, with new ones appearing each decade, then photosensitive rashes beginning 8 years prior to dx. So my best guess is that I had... (10 replies)
... somebody, your story hurts to read, but please don't apologize for it, ever! It's complex, so here's a suggestion for writing it down bare-bones. Jot down your symptoms, findings, and meds---in date order---using sentence fragments (to keep it short, because brevity helps doctors zoom in)---do so & take it along with you. That way, YOU won't forget anything, plus you could... (20 replies)
... do test where lupus is suspected. ... (20 replies)
... I have an appt. to get a second opinion for my infertility next month and I will bring all this up with him as well. Hopefully he'll agree to test me for the antiphospholipid antibody syndrome. Is this just 1 blood test? ... (6 replies)
... Lori, Where lupus is a possibility, I think elevated B.U.N. and creatine in bloodwork are signs kidneys aren't filtering properly. (I just reread your original post & realized you said those values were NOT QUITE out of range.) And urinalysis includes checks for "urine casts" and for protein in the urine, which are also signs of abnormal kidney function.
Have they... (6 replies)
... DNA with a negative ANA. Just to note, you can still have children if you have APLS, they don't all end in miscarriages. A miscarriage is just a red flag to test for this. I never understood why people who miscarry, aren't automatically tested for this. ... (6 replies)
... DNA is just one test that is specific for lupus. Although yours is a low positive, the number may change over the next few years and it should definitely be watched. ... (6 replies)
... My dr. had said all my tests were fine. The ANA screen came back negative though. Should I inquire about the Anti DS DNA? ... (6 replies)
... I remember having a blood test done a while ago when I was being worked up for something else, and the test said something about being positive for anti ds-DNA ase, and I know this is an antinuclear antibody, but does it mean that I'm going to get lupus at some time in my life? Or does it just mean that I had inflammation or something? My aunt has lupus, scleroderma, and... (1 replies)
... Melissa, very *high* anti-ds-DNA points strongly to lupus, but *slight* elevations are possible in some other conditions. In fact, a very high finding would fulfill one of the 11 ACR criteria. But without the reference range, it's impossible to tell how high yours is; so when you discuss your findings with your doctor, you should ask for the range & ask how high he/she deems... (5 replies)
... Hi. Do you have hardcopy of the labs, or were results read over the phone? My lab prints out-of-range vs. in-range values in separate columns.
For anti-ds-DNA, my lab uses these ranges, BUT there's no guarantee your lab uses the same. For something this important, I'd ask the doctor for hardcopy.
< 25, Negative;
35-99.9, Weakly Positive;
100-200,... (2 replies)
... DNA test was done. ... (3 replies)
... Hi. Apparently anti-ds-DNA can vacillate: it can be higher just before, or at the start of, flares; and once it turns positive, it stays positive. I don't know that it's a titer test, though (sorry), you'd have to ask. Unfortunately, if the reference range on the report says >10 is positive, then >20 appears to be solidly positive, but you should confirm with someone familiar... (3 replies)
... your test results. ... (3 replies)