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Cancer: Cervical & Ovarian Message Board


Cancer: Cervical & Ovarian Board Index


Am I alone or has this happen to other postmenopausal women? Five years ago I went to my ob/gyn complaining of pain on intercourse. My doctor told me it was because I have low estrogen. She prescribed vaginal estrogen tablets and instructed me to insert the estrogen tablet up into much vagina daily for two weeks and then inserted vaginally twice weekly. The estrogen helped sexual intercourse (no pain).

But the next year went back for my Pap test it was abnormal. A follow-up LEEP was performed and showed that I had cervical cancer! I needed a total hysterectomy.

My question is did the vaginal estrogen tablets cause my cervical cancer? (I was never tested for HPV). Have other postmenopausal women who have used vaginal estrogen tablets have/had similar experiences? Have other postmenopausal women developed cervical cancer, after using vaginal estrogen tablets:confused:?
I have no idea whether the estrogen can cause, cervical cancer but if I were to guess, I'd say yours was not caused by estrogen. I say this because cervical cancer is usally quite slow moving . . . so you probably have had this issue going on for more than a year. Maybe the estrogen helped speed things up? I really don't know.

I'm assuming your doctor did a pap smear when you went in for painful intercourse? Cervical cancer can definitely cause painful intercourse. But I doubt that was the cause of your pain since the estrogen caused the pain to go away. Pap smears are great, but they are far from perfect and might have missed something. Again, I really have no idea about this one!

I defintely think you should ask these questions to your oncologist.

I'm sorry this happened to you. Did you have surgery already? Are you okay other than the surgery?
I question the estrogen thing myself. Why is AIS more prevalent with people that used oral contraceptives long term or why is dysplasia more common in women with many pregnancies? There's got to be something there.
all of my Pap tests have been negative, up until the one after using the estrogen tablets was positive. Thank you for asking I am okay after my surgery. However, I do have swelling in my legs.
[QUOTE=Elizabeth1975;3950736]I question the estrogen thing myself. Why is AIS more prevalent with people that used oral contraceptives long term or why is dysplasia more common in women with many pregnancies? There's got to be something there.[/QUOTE]
I know of 4 other women who also used vaginal estrogen who developed cervical cancer within one year time.
all of my Pap tests have been negative up until I use the vaginal estrogen than one year later it was positive. I had a total hysterectomy so far I am cancer free. However, I do have swelling and dry skin in my lower legs.
[QUOTE=Louise Erdmann;3950579]Am I alone or has this happen to other postmenopausal women? Five years ago I went to my ob/gyn complaining of pain on intercourse. My doctor told me it was because I have low estrogen. She prescribed vaginal estrogen tablets and instructed me to insert the estrogen tablet up into much vagina daily for two weeks and then inserted vaginally twice weekly. The estrogen helped sexual intercourse (no pain).

But the next year went back for my Pap test it was abnormal. A follow-up LEEP was performed and showed that I had cervical cancer! I needed a total hysterectomy.

My question is did the vaginal estrogen tablets cause my cervical cancer? (I was never tested for HPV). Have other postmenopausal women who have used vaginal estrogen tablets have/had similar experiences? Have other postmenopausal women developed cervical cancer, after using vaginal estrogen tablets:confused:?[/QUOTE]
YES, oestrogen DOES cause cancer. That's because they do not give human oestrogen. It's from HORSE URINE, and about 200 times as strong as human hormones. Never meant to be inside any woman. A good herbalist would have treated you naturally and with no side effects. No cancer, either.
Yes, estrogen (estradiol specifically as it is the strongest estrogen) can be a contributing factor, especially in postmenopausal women whose e levels are supposed to be lower. Raising estrogen levels higher is generally worse for older women than younger women because younger women have naturally higher levesl of e. Estradiol promotes rapid cell proliferation and turnover, which is great if you want long healthy hair and strong nails and beautiful skin, but bad if you have hrhpv and atypical cells. That said, in the absence of obvious immunocompromise, a two-week course of intravaginal estrogen will not cause cervical cancer. It probably wouldn't even be a contributing factor. Your prior paps were false negative. There was no need for hpv testing because the presence of hpv is a given unless it was one of the super-rare types of cervical cancers like small cell or clear cell (in which case you would (hopefully) be told and (probably) be asked all sorts of questions about what your mom took during her pregnancy with you). What kind of cancer did you have (squamous cell or adenocarcinoma) and what kind of pap did you have done (conventional or liquid based)?
Cervical cancer is caused (>99% of the cases) by HPV. There is a link between artificial hormones (birth control pills, HRT, etc) and increasing the risks of cervical cancer . . . but the HPV has to be there first.

It is entirely possible (and probable) the HPV has been there for years or decades, but it is just detected.

Do you know what type of cancer you have (squamous/carcinoma or glandular/adenocarcinoma)? What stage are you? Have you been to see a gynecological oncologist? Have you set a surgery date? Sorry for all of the questions. The answers will be able to help me understand the situation so I/we can give better suggestions/comments.

I'm sorry you are having to go through all of this.
[QUOTE=Elizabeth1975;3950736]I question the estrogen thing myself. Why is AIS more prevalent with people that used oral contraceptives long term or why is dysplasia more common in women with many pregnancies? There's got to be something there.[/QUOTE]

below Is the Answer to Yours/my Question: If estrogen did not cause my cervical cancer, then why are anti- estrogen medications being used to treat cervical and vaginal cancer?

{DELETED}
I used the intravaginal estrogen for two weeks straight. Then for the next year I inserted the intravaginal estrogen twice per week. I have had a Pap test every year for the past 40 years .(40 years of false-negative Pap tests?) that's hard to believe. No my mother never took diethylstilbestrol (DES) when she was pregnant with me. If I'm not mistaken DES causes clear-cell vaginal cancer not cervical cancer. According to the pathology report my cancer invaded 4 mm of the squamous epithelial (transformation zone) .since my posting I have heard from 6 more women who have also used intravaginal estrogen and developed cervical cancer within the year. How many more women are who are still using estrogen and are HPV positive? Please share your experience with me. the more I read about estrogen, HPV, the more positive I am, that if I did not use the estrogen I would never have had cervical cancer.
The two-week course of intravaginal estrogen didn't have an effect. The twice weekly for one year course may have tipped the scales against you. Unfortunately, your 40 years of paps included many paps that were false negatives. I'm not saying all 40 paps were falsely negative, because assuming you weren't more recently exposed by a new partner, hpv can go in and out of dormancy, so very likely your pap was falsely negative for some 7-14 years which is the typical amount of time it takes for hpv to cause cancer, if it does. Now, there are two strains of hpv that are both the most prevalent and the most virulent: 16 & 18 (you may already know this) each of which can cause minimally invasive cancer in perfectly healthy women in as little as 18 months' time, but this is very unusual. The former is responsible for almost all SCCs of the cervix, and virtually all SCCs of other parts of the body (vagina, vulva, oral cavity, anal, penile, even carcinoma of the finger. Yes, finger) while the latter prefers glandular cells.

When you consider that a conventional pap has a sensitivity of 50% or less, and a liquid based pap a sensitivity ranging from 60-80%, you'll see how easy it is to obtain false negative results, even repeated false negatives. Case in point: another member here, Pickle Eyes, also had decades of normal paps, by liquid cytology no less...and they also discovered minimally invasive adenocarcinoma. Now, I admit it is very unusual for SCC (as opposed to adeno) to be missed again & again, and that's why I asked what type of cytology you've had, conventional or liquid. Perhaps your doctor doesn't know how to take a good pap, or your pathologist repeatedly misread slides. That is also why it is CRUCIAL to have additional hpv testing--not as a "reflex," but as automatic SUPPLEMENTAL TESTING! The hpv test currently available is not the most sensitive test, but combined with the pap it does the job well enough, and I will be getting this at least once a year until I die or until a therapeutic vaccine is on the market (and perhaps even then, because hpv is such a beast). DEMAND this test from now until whenever.

Yes, des causes clear cell adenocarcinomas of the cervix and of the vagina. It's a very specific type of cancer that occurs almost exclusively in very young women (teens, 20s at the oldest).

This is terrible news out of nowhere, but you're at the earliest stage when you can be treated very successfully with very low incidence of residual issues. Best.
Yes I agree my most recent pap which of course was cn3 started after I also started to take estrogen vagina inserts twice a week and then went to the prempro. I had clear paps until 6 months ago. For years I had clean paps, so it does appear from reading and searching that there is a big connection between the two. I no I am living it. Thanks to all for all your informational posts.
This is exactly what is happening to me right at this moment. I was put on Vagifem internal tablets in February and had to insert one a day for two weeks and then two a week for 10 weeks. have finished the course now but recently started 'spotting'.
.
Worrybug, I am concerned how are you doing now? You said you developed spotting. In all how long did you use the estrogen vaginal inserts? Where your pap tests normal, Are you HPV positive?;)





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