... oduced adequate testosterone so that it shuts down almost all of further production. That cuts off a key fuel needed by the prostate cancer cells. In contrast, degarelix is an "LHRH antagonist" drug, meaning that it blocks the receptor for LHRH so that the body cannot signal that it needs more testosterone. ... (2 replies)
... Hi gisa,
I'm hoping you will get some helpful and reassuring information here from a number of us. Here is some information I know about as a seventeenth year survivor of a once life-threatening case, but keep in mind that I have no enrolled medical education and was woefully ignorant about prostate cancer when I was diagnosed.
First, what a wonderful response your dad... (1 replies)
... Hi again Szam,
As I mentioned before, it would help to know more about your case, but I can well understand that your challenging circumstances may be occupying your full attention. That sure was the case for me and many others with prostate cancer when things weren't going well. :confused:
While you believe that you "have gone down every hormone therapy available,"... (2 replies)
... More Thoughts
Hi again Michael,
Re your question 1 about the period needed to measure doubling time: my hunch is that 8 months is enough, but I sure would want some follow-up to see if there was an up-and-down pattern or stabilization. If it were me, I would want a test in about a month.
Re your question 3 and preceding comments about ProstVac, as well as question 5:... (3 replies)
... Here's the story on the role of the NaF18 PET/CT scan and what the doctor probably meant. That scan is excellent at picking up small metastases of prostate cancer to bone. If a patient has such metastases, then radiation as normally delivered by seeds or external beam is not going to be able to treat those metastases, and they will continue to grow. ADT on the other hand... (5 replies)
... I saw your response on another thread and just wanted to encourage you on the course involving radiation and ADT. It is possible to do imaging that will give a much more precise view of whether there are bone or soft tissue metastases, but such imaging needs to be done before ADT has knocked the cancer down so far that it is hard to pick up remaining cancer. (ADT can knock... (5 replies)
... I thought my own cancer was metastatic, so I'm familiar with the options to smoke out what's up.
It's quite possible your husband has what is called "oligometastatic" (meaning few mets) prostate cancer. In simple terms, that amounts to around 5 or fewer bone mets, and soft tissue mets that are not too widely spread. With more than 5 bone mets, the cancer tends to be more... (2 replies)
... I went to UCLA to consult with Dr Kamrava about HDR and UCSF about whatever Dr. Roach would recommend. At UCLA, after my 3tMRI, he suggested HDR with a Lupron(22.5) shot now and a total of 6 to 9 months. He also said to stop the Avodart since it is apparently not doing any good. I would get the Lupron shot and 3 weeks later 1 day of prep and HDR the following day. Followup... (15 replies)
I've never posted on any site, but I've been reading all of your helpful messages for a few months.
My husband was diagnosed with prostate cancer in September. He has Gleason 9, with metastasis to his bones. He is in his mid-60's. Right at this moment I have my coat at the ready in case he has to get catheterized at the hospital. Usually he is urinating frequently... (2 replies)
... Thanks, Allen.
I will check out what additional medications are available to my dad. (15 replies)
... Has his testosterone level come down to less than 50ng/dL (1.74 nmol/L) or preferably below 20 ng/dL (.69 nmol/L)? It may be that he requires a different GnRH agonist or, even better, if available there, a GnRH antagonist like Degarelix (Firmagon). An antiandrogen will help stop whatever T or other androgens are left from turning on the cancer cells. Bicalutamide is the #1... (15 replies)
... A recent comparative study among men with metastases who responded to hormone therapy found that continuous hormone therapy extended life longer than intermittent therapy.
Which hormones he takes may depend on his response as measured by his PSA. The goal is to drive his PSA down to undetectable levels and keep it there. Lupron sends a signal to the pituitary that increases... (33 replies)
... What a shock that must have been for your father and you, and unlike many men with lower risk PC, he has to proceed quickly to treat and hopefully cure his locally advanced disease. It's great that you have gotten so many opinions so quickly. Florida has several great cancer centers.
I presume he's started the hormone therapy already, which should stop the progress of the... (3 replies)
... I think that a PSA nadir of .2 is too high this early in the game. If Lupron isn't doing the job, try Degarelix; if bicalutamide isn't working, switch to nilutamide; if finasteride isn't working, try dutasteride. Try higher doses. Everyone responds differently to those drugs, and thank God, there are enough choices out there that you can find the right drug cocktail and the... (4 replies)
... It may take a few weeks for all testosterone to be stopped. So it paradoxically eliminates testosterone by first causing it to increase. There is a newer drug, Degarelix that shuts it off directly without an initial increase. This is known as "chemical castration,' and accomplishes the same thing as physical castration. ... (10 replies)
... The reason Avodart cuts PSA in half is mostly because it gets rid of the effect of BPH on PSA. If you have no prostate gland, you have no BPH. The effect on reducing DHT-fed cancerous production PSA is much smaller. Because of this you may not want to wait for a higher PSA level when you're on solo Avodart therapy.
You might be interested in the following study conducted in... (8 replies)
... Hi Michael (yarbo3),
I'm responding in green to your post a couple posts back about Firmagon.
Firmagon is the trade name for degarelix, which was approved by the FDA on 12/24/2008 (a Christmas present). It's similar to the LHRH-agonist drugs but not exactly in the same class, as it is an LHRH-antagonist, the first one to be approved. It has some advantages over the... (50 replies)
... ARI function to the degarelix and the bicalutamide. ... (6 replies)
... My worst fear has come true...My Dad is in pain and suffering from cancer. Here is his info. Any ideas, suggestions regarding what we can do and what to expect are greatly appreciated!
Name: RRW (aka: My Dad) Born in: 1943
1 pack per day smoker for 40 years. Quit 10 years ago.
His Father died of prostate cancer that had metastasized to bones and organs... (6 replies)
... Hi Brenda,
Your husband's case is serious (as is mine), but there is a solid basis for hope! The result could be surviving the cancer, or it could be many good years.
Many of us with challenging cases are given short prognoses by our doctors, often five years, or sometimes just a couple of years. Fortunately, they often do not know what they are talking about! :D In... (52 replies)