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What side effects has everyone had if any?
LOL, this is just way to funny. Years later I discover that the dosage for Spiro is on average is 50 mg to treat hirsuitism and/or acne. Yet I was taking 4x that amount for several years.

I personally consider my acne to be severe because If i stopped treatments (I've always been on some sort of treatment topical or oral), I would have various amounts of scalp acne, neck acne, ear acne, facial acne, body acne, underarm cysts, and sometimes in other places too.

I am capable of getting white heads/sugar pimples, some black heads, regular sized pimples, tiny nodules, and cysts. Not only that my skin loves to hyperpigment so I definately hated having to get the more painful stubborn cysts or nodules because they would leave marks that took 2 - 3x as long to remove (acne is only half the battle).

I've been dealing with some sort of acne for the past 17 years. It's really interesting because I never ran to my dermatologist to get a cyst reduced. I stuck it out the 1 - 3 weeks that they would last. I never did a lot of things some of you did externally, because I [B]knew[/B] it was an internal problem. So I guess that's why I'm more knowledable about the whole endocrinological and hormonal testing aspect, but feel completely cluess when you guys talk about peels and lasers, etc ;-)

Although, I've done enough externally, racked up a enough debt on products and supplements, and it never permanently solved anything. To me, it was a complete waste of time, energy, and money and especially HOPE, to do those things, when the acne would keep coming back (anyone else felt that way). So after [U]several[/U] attempts I finally got doctors and a great endocrinologist to listen to me.

I went on Birth Control (BC) at age 17. After 3 months, my acne had improved by 50%

I added 200mg of Spironolactone (Spiro) a few months later at age 18. My acne improved by (it's hard to remember) a total of 60% - 80% depending on the season. Meaning w/ the BC & Spiro combo, I would be my clearest (80%) for only 3 months out of the year (summer season).

Several years later, thanks to a minocycline backlash (totally pissed my skin off when I stoped), BC & Spiro weren't as effective. I was only on it for 3 months (it raises your DHT levels, but reduces inflammation) and it managed to give me my clearest skin yet of 98-99% (during the summer) with the other 2 drugs. I stopped out of fear of resistance and yeast infections, etc.

A few months of that h*ll and I cried depression to get off the BC, and with great luck I was referred to my 3rd endocrinologist. Ran practically every test in the book (had to go off of the both meds) and dx me as Insulin Resistant or Polycystic Ovarian Syndrome (PCOS) and since they both use the same treatments, he put me on Avandia. 2mg of Avandia for a few months wasn't cutting it and so I added back in 150mg of Spiro. Together this combo gave me 70% - 85% clear skin. It still wasnt' enough.

In total I have taken Spiro for 6 years and it in combination with other drugs, has NEVER given me 100% clear skin. You guys are very lucky because it looks like your hormones aren't that imbalanced or that your skin isn't that sensitive to DHT. Even when I changed my diet and dropped the avandia, Spiro plus my customized Diet didn't give me clear skin, but close 99%. Now that I am off of Spiro, I am still 99%, but req. something similar to help with the mild hirsuitsm. That's why I'm playing around with Saw Palmetto (and glutathione) at the moment.

From personal experience, from the testimonies of others, and even medical protocols suggest this, you will always have better luck with a Diet & (minimal dose) Med or/Supplement combo than you will with medications alone. Heck, if you REALLY want it, depending on your health problems, you may able to do it purely through dietary means. It's rare if I hit 100% clear skin, because I don't follow every dietary recommendation that I know I should. Slowly but surely though I am improving my diet (I can see those changes on my face). I know I'll hit that mark just as many others that I've met and worked with on this board have.

If you are going to take drugs you need to make sure that you are getting at least a liver panel done every 2 - 4 months. Spiro has lots of side effects, but it has the least dangerous of side effects compared to Flutamide (more effective). I never experienced anything behind feeling a bit tired (which is why I reduced it), a decrease in sex drive, and freg. peeing (which subsides). Now that I'm taking tons of Saw Palmetto (1620 - 3240mg day), I am not experiencing any of those symptoms (some men do though). It is supposed to be 10% more effective so I will keep you posted!

That's my 2 cents
hi everyone!

i am a new member although i have been following these threads for the last week. some of you may recognize me at ********* as "malia". anywho, i am very interested in your experiences with spironolactone. it seems we are all in this endless quest to find that magic bullet. it is so great to see that something has finally helped some of you.

so far i have been on about 4 courses of Accutane, nearly all Rx meds (which seem to be too harsh for my skin), and every OTC possible. what i've found that internal treatments work best for me since i have fairly sensitive Asian skin. unfortunately, after each course of Accutane i would start breaking out in a month after i stopped...often worse than before. SweetJade's posts have educated me immensely on the effects of Accutane on insulin tolerance and i think that over the many courses, my insulin-resistance has compounded and made my acne linger longer than if i just hadn't done anything at all.

i read that spironolactone is a steroid...should we be concerned about this classification? not all steroids are bad but the fact that it is suggests that its effects/side effects may linger for a long time. i have not been to see a doctor about spiro but i have ordered it online...but i am scared that it is safe!

i'd greatly appreciate any input! thanks a bunch!

For those asking about hair reduction, results aren't noticable until 3 or 6 months. Then after 1 year you should see further results. So far the BEST combination for my body hair reduction was Spiro and Diet.

Since I've stopped the spiro the hairs that fell out are growing back in. So I'm currently dabbling with the natural versons of spiro to see if they will produce the same effects, but my patience is starting to wane. I'm researching a few other things in this area and am trying to come up with a few concoctions. However, I'll give this to the end of the summer and then I'm back on Spiro (until I can start lasering some off).

The reason I'm doing that is more so out of fear & prevention. I've been lucky so far, but it's only going to get worse (I fear). Once your hair follicles are activated by DHT, they maintain their sensitivity, despite a reduction of hormones naturally as we age. So the longer you mess around (or the doctors mess with you) the more body hair you may be growing that will "always" be sensitive to DHT and continue to grow (or fall out if on your scalp).

So if you have acne, body acne, alopecia, and/or hirsutism definately think about adjusting your diet and taking Spiro (legally). IGF-1 isn't just responsible for skin cell growth but also hair growth (and increases DHT). So avoiding all you can that contain's added IGF-1 or that will boost IGF-1 in your system is a good idea. You can't eliminate all of it, but you can reduce it. Dairy, Caffeine, MSG, Saturated Fats, Hydrogenated/Partially Hydrogenated Oils, Gluten Grains for starters.

HTH =)
sweet jade:
did the hair actually fall out??...i was under the impression that it would slow hair growth but the hair had to be lasered or electrolocized for removal...i'm on 50 mg/day plus yasmin now. I've had no adverse side effects from either thus far but it's only been a week, too soon to tell...i've got another appt. with the endo in about 4 weeks and he says if i can tolerate the combo, he might consider upping the spiro...i'd like to up the spiro now, as i'm not sure the 50 mg. is enough...thanks again for all your advice.
Yes the hairs do fall out. The hair goes through 3 phases of growth (not an expert here) but eventually they will die out (and fall out). My fastest results were from waxing or plucking. Those hairs would grow back finer and finer and one day they stopped. The density of area of hair growth also thinned out on my skin and the remaininig hairs were a bit lighter or finer. Although, there's other areas that I never did anything to, and those hairs fell out on their own accord.

I don't know how much spiro is needed for you but the more you take, the more it should work. However there is an increased chance of side effects the larger your dosage is. All I know is that Spiro was helpful, but by far was no miracle cure for my acne or hirsutism. Yet with it combined with my customized diet, it provided the best results in reducing/preventing unwanted body hair. Depending on where the hair was that was a 25% - 90% reduction. Unfortunately it does nothing for improving the hair growth on my head.


P.S. Joeh thanks for the info on lasers. That's currently my task. In the distant future, my Daddy actually said he'd pay for it!

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