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Minocyclin will make your skin worse if you use it long term, it may not make it worse but eventually it will stop working and your body will get immune to it. I have used pretty much all of those medicines and they worked for a while and then stopped, then the derm would switch me to something and it would work for awhile then stop, and this cycle would repeat over and over. These medicines are premanent solutions to acne, they're just temporary.

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