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Re: Sugar Sugar!
Nov 18, 2004
Hmm... give a normal or acne free person [B]IGF-1[/B] and what happens?

[QUOTE]Clin Endocrinol (Oxf). [B]1998[/B] Jan;48(1):81-7. Related Articles, Links

[B]Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome.[/B]

Klinger B, Anin S, Silbergeld A, Eshet R, Laron Z.

Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center of Israel, Tel Aviv.

OBJECTIVE: Patients with Laron syndrome (LS) can now be treated with recombinant IGF-I. We describe the development of androgenization during IGF-I treatment of female LS patients. PATIENTS: Six female patients with LS--two clinically prepubertal (11.6 and 13.8 years of age) and four young adults (30 to 39 years old)--underwent long-term replacement treatment with recombinant IGF-I. The daily doses were 150 micrograms/kg/day by subcutaneous (s.c.) injection in the girls and 120 micrograms/kg/day in the adult women. METHODS: Testosterone, delta 4-androstenedione, LH, FSH, insulin and IGF-I were determined by radioimmunoassay. Blood samples were obtained after an overnight fast before the IGF-I injection. Serum IGF-I was also determined 4 hours after the s.c. injections. RESULTS: During IGF-I treatment, four out of the six patients (two girls and two adults) developed progressive clinical symptoms and signs of hyperandrogenism (oligo/amenorrhoea and acne). Laboratory determinations showed a significant elevation in serum testosterone, delta 4-androstenedione and LH/FSH ratio. The hyperandrogenism occurred concomitantly with an increase in IGF-I serum and a decrease in serum insulin concentrations. Reduction in IGF-I dose or interruption in IGF-I treatment restored androgen levels to normal values. At the same time, the acne and oligomenorrhoea resolved. CONCLUSIONS: Overdosage of IGF-I can lead to androgenization, a previously undescribed undesirable effect of IGF-I. Long-term IGF-I treatment necessitates progressive adjustment of the IGF-I dose to avoid overtreatment.[/QUOTE]

[QUOTE]Endocr Rev. [B]2000[/B] Aug;21(4):363-92. Related Articles, Links

[B]Role of hormones in pilosebaceous unit development.[/B]
Deplewski D, Rosenfield RL.

Department of Medicine and Pediatrics, The University of Chicago Pritzker School of Medicine, Illinois

[B]Androgens are required for sexual hair and sebaceous gland development. [/B] However, [U]pilosebaceous unit (PSU) growth and differentiation require the interaction of androgen with numerous other biological factors[/U]. The pattern of PSU responsiveness to androgen is determined in the embryo. Hair follicle growth involves close reciprocal epithelial-stromal interactions that recapitulate ontogeny; these interactions are necessary for optimal hair growth in culture. [B]Peroxisome proliferator-activated receptors [/B] (PPARs) and [B]retinoids[/B] have recently been found to [U]specifically affect sebaceous cell growth and differentiation[/U]. [B]Many other hormones such as GH, insulin-like growth factors, insulin, glucocorticoids, estrogen, and thyroid hormone play important roles in PSU growth and development. [/B] The biological and endocrinological basis of PSU development and the hormonal treatment of the PSU disorders hirsutism, acne vulgaris, and pattern alopecia are reviewed. Improved [U]understanding of the multiplicity of factors involved [/U] in normal PSU growth and differentiation will be necessary to provide optimal treatment approaches for these disorders.[/QUOTE]
(Full Text Available...maybe someone should read it)

[quote]Acta Derm Venereol. [B]1997[/B] Sep;77(5):394-6. Related Articles, Links

[B]Isotretinoin, tetracycline and circulating hormones in acne.[/B]

Palatsi R, Ruokonen A, Oikarinen A.

Department of Dermatology, University Central Hospital, Oulu, Finland.

Isotretinoin, used to treat severe acne, has been shown to induce hormonal changes, especially to reduce 5 alpha-reductase in the production of the tissue-derived dihydrotestosterone (DHT) metabolite 3 alpha-Adiol G. However, the effects of isotretinoin on other pituitary, adrenal or gonadal hormones have not been thoroughly elucidated. In the present study, isotretinoin administered at a dose of 0.5 mg/kg/day for 4 weeks caused no marked changes in the serum levels of pituitary, adrenal or gonadal hormones or 3 alpha-Adiol G in patients with severe papulopustulotic acne (n = 19). After 12 weeks of therapy, there was a decrease in the levels of the precursor androgens androstenedione, testosterone and 3 alpha-Adiol G in 6/9 patients. Acne improved after 4.5 months in all but 2 male patients, who had very low serum hormone binding globulins (SHBG) and a high free androgen index (FAI). Isotretinoin did not affect the elevated LH/FSH ratio in a patient with the polycystic ovarian syndrome (PCOS); nor did it change the high FAI or low SHBG in the male patients. For comparison, tetracycline had no effects on the serum hormonal levels of patients with mild acne (n = 19) after 7 days of treatment. This study confirms that the effects of isotretinoin on the serum hormone levels are small and unlikely to be of relevance for the resolution of acne or the suppression of sebum excretion.[/quote]

There's studies dating back to 1988 discussing retinoids antiproliferative effects (accutane was originally used to treat cancer) so above may explain why antiandrogenic retinoids such as Isotretinoin AKA 13-cis Retinoic Acid AKA Accutane, don't permanently work for everyone (not strong enough or cease of treatment?).

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