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[QUOTE=Neca]Hey SweetJade how's it going :wave: , wow it's good to see that you are still here helping people out with your amazing knowledge. I don't know what a lot of us would do without your insight! Well I was just browsing the forum and have stumbled on a lot of info regarding anti-androgens especially amongst your post and it is beginning to really interest me as I am convinced my acne is hormonal. In your last post you wrote:

Do you know how effective these A/As are at preventing acne and do you have any info regarding the types available, preferably in natural form. I have read that Saw Palmetto is an A/A but many people have suffered from Thyroid problems as a result? So how risky is A/A use and does it need to be carefully monitored by a doc?

Thanks in advance for any info and good to see ya again :)[/QUOTE]

Oh wow, well thank you =) Regarding Androgen Antagonsits, they fall in many catagories. Some are best used for certain genders, but some of these should probably be used for all genders. The most popular ones used orally for the treatment of acne are [B]Accutane[/B] (see previous posts), [B]Spironolactone[/B] (androgen receptor blocker), [B]Estrogen/BC[/B] (increases SHBG to bind free androgens) & it's questionable when it comes to the prescription specific 5-alpha reductase inhibitors such as Avodart & Proscar.

There's herbals that can act as 5-alpha reductase inhibitors as well as Saw Palmetto is one of these. If you are concerned about it messing with your thyroid, then you can take the active component, [B]Beta Sitosterol [/B] instead. I actually have a list of natural androgen antagonists and I look for that and post it for you later.

In the mean time, as for prescription androgen antagonists, there's also the indirect ones such as Glucocorticoids & Insulin Sensitizers. Normally glucorticoids (dexamethasone & prednisone) could induce acne, but if you have an adrenal imbalance they will do the opposite & they are also anti-inflammatory too. The Insulin Sensitizers help to either limit the amount of insulin you produce (Metaformin) or enable your body to better utilize insulin (Avandia). Either way, they both work to lower you androgens, free androgens and boost your SHBG levels, thus help reduce/eliminate acne. The same goes for thyroxine hormone for those that are hypothyroid. Hypothyroids also have a reduced level of SHBG due to lacking thyroid hormone. Boost your thyroid hormone & your SHBG will also increase and thus your acne should also be eliminated.

Depending on the severity, the susceptibility to one's environment (diet, toxins), and perhaps sensitivity, will determine how effective prescription & supplement androgen antagonists are for you. As you may have noted on the board, some of these drugs alone are enough to get people 100% and other times, such as for myself, they were not. I'm more influenced by my diet (which is also an indirect androgen antagonist) and as such I found that I got better results by changing my diet, even when I dropped the avandia (BC, & spiro). I actually have a studyposted around here (bread & acne thread?) that shows that dietary changes with metaformin was no different than dietary changes alone! I'm 24 and have had acne since I was at least 10, yet something that "simple" worked for me. Indeed, the success of any treatment really depends on one's genes & environmental influences.

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