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smite...[QUOTE]Alright I'm back from vacation and going to start most of the regimen outlined by kkpb as of tomorrow. I have to admit though that I started a bit early and grabbed a box of zantac 75 while heading out of town last Friday, so I have a bit of a early review. I've taken 2 a day since then with hopes that it would lessen the flushing effect that I usually experience with alcohol, which I'm happy to say that it certainly did. In addition, the following day after a heavy night of drinking my pimples generally seem much more inflamed and sensitive to the touch. While taking the Zantac this did not seem to be the case, but obviously there were plenty of other variables that changed while on vacation to say this was solely due to the rantidine. Overall, my complexion has improved in the last 5 days, but, again, I can't say that's not due to the sun, surf, or other factors.

I'll be sure to keep everyone updated.

I did have a question for kkpb or anyone else regarding the histadelic metabolism though. Based on this developing theory, what effect, if any, will the H2 antagonist (rantidine) have on the rapid metabolism that is often seen with histadelics? If it is totally unrelated, is there anything that can be used to regulate or slow down a rapid metabolism?[/QUOTE]




Sorry ive been away a few days...but there are a few questions here
Firstly to smite..i think that you will see the best results when you start to control any insulin resistance that you may have as well as any digestive issues (intestinal hyperperameability) in addition to the histadelia..They are all important contributors to the immune imbalance that underlies the tendancy to have delayed type hypersensitivity reactions..i.e. ACNE

I have been doing more research on the role that METHYLATION has on histadelia..this is a new area of scientific research so some studies are currently being done..however it seems (in responce to your question, smite) that methylation disorder (acne sufferers are low methylators) determines the high histamine levels and it is exposure to the histamine in the womb and early development that determines many of the structural features of the syndrome, such as long fingers.

however the functional features (such as excessively fast metabolism, increased secretions such as saliva, acid and mucous) may be brought ubder some control with H2 antagonists.

BUT it is important to realise that the H2 antagonists primarily act to re-address an imbalance in the immune system rather than alter histamine levels...this can be done by increasing your methylation...


If you remember...low methylators have [B]LOW ZINC, LOW SULPHUR and HIGH COPPER levels,they also have LOW SAMe and LOW VITAMIN C levels [/B] so these could be supplemented...(zinc picolinate 50-80mg, and MSM 5-10g per day vitamin C 2-? g per day)...copper from tap water should be restricted because this can be VERY high...


If u remember the methylation pathways are designed to do three basic things, 1). produce enough SAMe 2). Lower homocysteine levels 3). produce cardio-protective antioxidants such as cysteine (ie SULPHUR), taurine and glutathione

In acne we are concerned with 1 and 3....because SAMe is a METHYLATOR and is needed to DEACTIVATE histamine....if SAMe is low then HISTAMINE is high...thus promoting the immune imbalance
ALSO..low levels of sulphur can increase inflammation and reduce tissue healing...worsening acne...

As for your specific question...[QUOTE]Based on this developing theory, what effect, if any, will the H2 antagonist (rantidine) have on the rapid metabolism that is often seen with histadelics? If it is totally unrelated, is there anything that can be used to regulate or slow down a rapid metabolism?[/QUOTE]

If you control your carbohydrates then you will find that your metabolism balances anyway, due to less insulin flying around in your blood...also i have noticed since starting this that i sweat less, never get those awful hunger pains, im not so shaky etc.....

however i advice you to take account of the [B]EFFECTS[/B] of the rapid metabolism because it is these effects that contributes to the inflammation...ie the increased toxin load...(take a liver supporting supplement, or antioxidants like [B]ALPHA-LIPOIC acid[/B], OR [B]HAWTHORN[/B] (which removes cellular metabolic waste) or [B]VITAMIN C[/B] (which lowers histamine and mops up metabolic waste), an most importantly...[B]lots of vegetables..these are the only foods that dont really produce toxins when they are metabolised[/B]..because often that is the problem in histadlia normal healthy food is metabolised so rapidly that the body cannot deal with the toxic-overload which increases inflammation...coupled with an [B]intestinal hyperpermeability[/B] (which again increases immune inflammation) and [B]candiasis[/B] (increases toxins) and [B]low methylation [/B] (high histamine, low zinc low sulphur)..and [B]stress[/B] (increased inflammation) [B]insulin resistance [/B] etc etc..this theory brings all these causative factors together...for the first time..they all promote the immune irregularity that leads to [B]delayed type hypersensitivity[/B]



It is interesting that sweetjade has mentioned neutrophils..because it has always been theorized that minocycline works primarily by suppressing radical production by neurophils and thus lowering inflammation..in other words that is why tetracycline dont work immediately in acne because they are modulating the immune systems inflammatory responce...it is this that helps mainly in acne and not the fact they kill bacteria..

[QUOTE]
Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation.

Akamatsu H, Horio T, Hattori K.

Departments of Dermatology and Pediatrics, Kansai Medical University, Osaka, Japan. [email protected]

BACKGROUND: [B]Reactive oxygen species generated by neutrophils are closely correlated with the pathogenesis of a variety of inflammatory skin diseases[/B]. The aim of this study was to investigate the possible[B] role of reactive oxygen species generated by neutrophils in the mediation of acne inflammation[/B]. METHODS: Bacterial phagocytotic stimuli, mediated by opsonin activity, were applied to whole blood, and neutrophil hydrogen peroxide production was measured. RESULTS: [B][U]Patients with acne inflammation showed a significantly increased level of hydrogen peroxide produced by neutrophils compared to patients with acne comedones and healthy controls[/U][/B]. There were no marked differences in the level of hydrogen peroxide produced by neutrophils between patients with acne comedones and healthy controls. [B]In addition, patients with acne inflammation [U]treated by oral administration of minocycline hydrochloride, a drug that inhibits hydrogen peroxide generation by neutrophils, showed a significant decrease in the ability of neutrophils to produce hydrogen peroxide [/U] in accordance with a decrease in the inflammatory activity of acne lesions[/B]. CONCLUSIONS: [B]The present study seems to suggest that acne inflammation is mediated in part by hydrogen peroxide generation by neutrophils[/B].[/QUOTE]



[QUOTE]Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline.

Akamatsu H, Asada M, Komura J, Asada Y, Niwa Y.

Department of Dermatology, Kansai Medical University, Osaka, Japan.

[B]On the basis of a recent report that minocycline is effective in the treatment of acne inflammation by acting directly as an antioxidant on infiltrating neutrophils[/B], we investigated whether doxycycline might also be capable of reducing the generation of reactive oxygen species, using human neutrophils and a cell-free, xanthine-xanthine oxidase system. The species investigated are superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH.). [B][U]Doxycycline significantly reduced the levels of O2-, H2O2 and OH. generated by both systems. Our results seem to suggest that the clinical effectiveness of doxycycline in the treatment of acne inflammation is due partly to its antioxidant effect on neutrophils[/U][/B].[/QUOTE]



There are more studies on this just type in [QUOTE]tetracycline neutrophils acne[/QUOTE] to pubmed if you want to read them...



I would like to research what exactly causes the increase in neurtophil radical production? if anyone wants to look at this?




[U]A COUPLE OF POINTS ABOUT RANITIDINE[/U]


firstly you can lower the dose you are taking to once in the morning (75mg) and once in the evening after a week..then lower it again after about another week to once a day IN THE EVENING..because the stomach acid lowering effect will only last 12 hours (but the beneficial effect on the immune system seems to be much more long term because the effect is maintained with me on once per day) so when you wake up the stomach will be producing normal acid amounts...

secondly initially you may get some indigestion if you eat REALLY heavy RED MEAT meals..because alot of acid is needed to break weel cooked red meat down...but if you are doing this regime properly then you wont be eating too much red meat anyway..if you cant live without red meat then you should take an enzyme supplement (including HCL in the tab) before such a meal..with will resolve the issue


thirdly this should be a part of the whole regime to balance the immune system to suppress the Delayed type hypersensitivity, not taken on its own..





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