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Firstly iam very glad to have had such a response. I need to clarify a couple of points that i think may be confusing the issue.

Histamine is released by cells called mast cells when we come into contact with an allergen, the histamine causes our blood vessels to dilate, and then we flush. The histamine acts on receptors in the walls of the blood vessels, anti-hisamines block these receptors and so prevent the histamine from binding to the receptors. So anti-histamines can prevent flushing.

Now Acne-Rosacea HAS been linked to this flushing, and i think that if you react to certain foods by flushing then you may have Rosacea rather than acne vulgaris. However flushing does activate sebaceous glands. But It is VERY important to remember that anti-histamines DO NOT lower histamine levels, or decrease its production.

The reason that this theory is interesting, isnt that histamine can cause flushing that has been known for along time. The interesting thing is the little known LONG TERM effect that slightly (and continuously) raised histamine levels have on cellular metabolic rate.Not simply its effect in the short term on blood vessels.

The list 'antifaith' mentions is a comprehensive diagnostic list, but you dont have to have all of these signs to be histadelic. Every one will have a few of them more than others. The key point is that histadelia is the only metabolic condition that provides an answer to ALL of our signs.From the diagnostic list; I for example, have very long fingers, i sneeze in the light, have tension and depression, i burn food rapidly and have a lean build.

The important point is the wide ranging effects that long term raised histamine has on the body in all its systems. The key part is that we burn our foods rapidly, and thus more toxins are produced in our mitochondria, and over a long term period acne results.

With regard to therapies, there are many options, i dont believe that anti-histamines are one of them though. I have tried them for a long period and i don't think they helped. Some researchers point out that long term use can actually increase histamine levels!

Firstly, i have spoken to a chinese medical doctor, (chinese medicine argues that acne is due to a rapid metabolic rate) who provided me with two herbal concoctions, one of them was to decrease the toxic load on my liver while the other was to normalise my metabolism. I have also read widely in ayevedic medicine when i was putting this idea together, and interestingly ayevedic doctors say that acne is due to a metabolic 'constitution' called 'pitta'. People with This constitution burn foods extremely rapidly, and so find it hard to put on weight.

This is all well and good, but now i was asking why? Why are our metabolisms so fast? Then i remembered histadelia, and it all began to fall into place, now you see there is an action step.

So the 'treatment' that i put myself on was;

1). the two chinese herbal formulars (that can be purchased from a chinese herbal shop)
2). Methionine 500mg twice a day
3). calcium 1500mg per day (and magnesium 500mg)

4). Alpha lipoic acid 600mg per day, NO less

THIS ONE is very important, because as 'arock' so rightly pointed out, there was an experiment done on calorie restriction in rats. They found that far less toxins were produced by the rats when they were fed less food, and they lived 30% longer lives. A follow up experiment found that by supplementing the rats with ALPHA- LIPOIC acid and Acetyl L-carnitine at the correct dose they could replicate the effects of calorie restriction without restricting any calories. ALA is also an antioxidant, anti-toxin, it lowers blood sugar and cleans the liver.

The dose is very important though it has to be enough. (i dont use l carnitine bcos i cant afford too much, and ALA works well for me)

I also use

5). MSM 7g per day to help remove toxins from my cells and decrease histamine
6). Vitamin C 3g per day (stabilizes histamine release from mast cells)

Some final points, it may not be required to take all these things, i dont know which ones can be left out, all i do know is, and i dont like to make rash comments, because we've all been around the block for so long. But one week after i started ALL thses things together my right cheek became completely clear (it hasn't been like that since i was on accutane (the first time), and my left cheek had 2 very small comedones that normally i wouldn't classify as spots, but i want to be as accurate as possible.

I am not getting my hopes up, becos i realise things can change at any time, i am currently researching a diet that may help, that involves the ayevedic 'pitta' diet and the avoidance of foods that are high in histadine (the precursor to histamine).

Oh i nearly left the names of the two herbal formulations, i think that these are very important, and that the rest would still work but may take along time (as 'antifaith' pointed out).

They are:
1).pifubing xueduwan; (regulates a rapid metabolism) this contains about 40 herbs per tablet and 40 must be taken a day (each one is tiny)... i know alot, but there doesnt seem to be any side effects, i am under the watch of the doctor, and they don't need to be taken for very long (about a month, but this may vary with the individual)

2).Skin solution tablet, the herbal toxin remover, contains 7 herbs and 3 must be taken 3 times a day

Many will now think that is mad, but i am only reporting to you the only regime that has worked for me apart from accutane, now you've read the theory and i encourage you to resaerch this, because i firmly believe that it explains every aspect of our condition for alot of us, but ultimately you must make your own mind up.

thank you.. please post any more great ideas, because we can all learn from each other
if you have any more questions, i would be happy to try to answer
Hi All,
I've been following this thread with increasing interest, especially the science part of the theory.
I've controlled my acne for years with varying degrees of success with topicals (obagi), systemics (accutane twice, antibiotics almost constantly), also take 1 selenium/zinc/ vit c/ vit b combined tablet each day; but i know that underneath this sometimes smooth skin, i still have major acne.

Am thin, 114 pounds, 5 feet 7 inches, have too much energy, don't really sleep at night, have all the histadelic symptoms, allergic to horses, and sometimes allergic to aubergines and coconuts, but strangely, not all of the time. Also used to faint a lot... and feel cold a lot of the time.

Have PCOS, but don't look like it, in fact my doctor was shocked with my test results due to slimness and the fact that i have 4 children.. but here's why... i have never liked carbs, eat mostly proteins and vegetables anyway and have done so for years...do have a sugar and soda addiction, and drinking lots of water does nothing for my skin condition, and neither did giving up sugar for 6 months.

When I eat anything like bread or rice or pasta, I immediately feel tired, sluggish and sleepy, and I mean immediately, like within 15 minutes at the very most.

Also, I have NEVER had acne anywhere except on my face, in fact my bodyskin is very dry.
Strangely enough, all my kids were born prematurely @29 weeks, and in fact so was I!

How does this fit into your theory. Am planning to start taking the Zantac, but pl tell me, does Zantac have any horrible side effects if you're not taking it for heart problems or whatever it was deisned to treat in the first place?
thanks.
[QUOTE=finallyfreealmost!]Hi All,
I've been following this thread with increasing interest, especially the science part of the theory.
I've controlled my acne for years with varying degrees of success with topicals (obagi), systemics (accutane twice, antibiotics almost constantly), also take 1 selenium/zinc/ vit c/ vit b combined tablet each day; but i know that underneath this sometimes smooth skin, i still have major acne.

Am thin, 114 pounds, 5 feet 7 inches, have too much energy, don't really sleep at night, have all the histadelic symptoms, allergic to horses, and sometimes allergic to aubergines and coconuts, but strangely, not all of the time. Also used to faint a lot... and feel cold a lot of the time.

Have PCOS, but don't look like it, in fact my doctor was shocked with my test results due to slimness and the fact that i have 4 children.. but here's why... i have never liked carbs, eat mostly proteins and vegetables anyway and have done so for years...do have a sugar and soda addiction, and drinking lots of water does nothing for my skin condition, and neither did giving up sugar for 6 months.

When I eat anything like bread or rice or pasta, I immediately feel tired, sluggish and sleepy, and I mean immediately, like within 15 minutes at the very most.

Also, I have NEVER had acne anywhere except on my face, in fact my bodyskin is very dry.
Strangely enough, all my kids were born prematurely @29 weeks, and in fact so was I!

How does this fit into your theory. Am planning to start taking the Zantac, but pl tell me, does Zantac have any horrible side effects if you're not taking it for heart problems or whatever it was deisned to treat in the first place?
thanks.[/QUOTE]

Well try it and less us know how it goes. As for the trouble sleeping/insomnia this can be a symptom of PCOS/IR and so can feeling sleeping after eating (high) carbohydrate meals. Some members find that they can handle it, remove the brain fog, and decrease breakouts when they take ALA or the right form of K-RALA 15 minutes before their highest carb meal.
I am going to start taking Ranitidine today, but I am also on Accutane. I have been on and off Accutane the past couple months as my acne clears up, but it doesn't seem to do much of anything for me anymore. I went on a 5 month treatment, but still no results. It clears up when I am on the medicine and then gets bad again once I stop taking the Accutane. Since I am convinced that my acne is 100% uncurable except by altering me internally, I was wondering if it would be okay to take the Ranitidine and take the Accutane at the same time to prevent breakouts that might occur?





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