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Low Dose Accutane
Feb 6, 2009
6 Feb 2009
Hi, I have just taken my first low dose of Accutane
Brand:Sotret
Weight:90Kg=200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Supplements:None

Day 1
Chronic oily skin, blotting on the hour. I have mild Rosacea and more severe Acne Vulgaris of the nose and chin. My dermatologist in the USA had no real off label experience with low and microdose accutane. I brought him multiple studies from Israel, Turkey, UK and more.... he was interested. I have a back-up of Eythromyacin, I am hoping not to use it. I have been on Doxycylcline for the last year (this is not allowed with Accutane) since being diagnosed with Rosacea. My derm will only allow for a one month antibiotic security blanket. Eythromyacin does not have contraindications with Accutane, when its gone I have to ride it out. I am Professor at a local college, needless to say it is difficult to have skin problems and have to lecture in front of crowds. I hope I am lucky and can avoid the dreaded intial outbreak so many Accutane users report.

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.
7 Feb 2009
Brand:Sotret
Weight:90Kg=200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Supplements:None
New behavior: No alcohol or caffeine

Day 2:
I took my first Accutane 20mg pill last night at 9:00 with a bowl of oatmeal some apples and a big glass of water. Slept fine, no reported side effects. I will continue to take my dosage at night before bed. My acne is very controlled right now, I have been on daily Doxycycline for months. So, I guess so far so good.

Day 2 continued: Rosaceans I did have a flushing episode today, it was short and faded within minutes. I don't know if I can blame the accutane or not. I no longer have the security blanket of Doxycycline since it is forbidden with Accutane. I have one month of Eythromyacin but I am holding on to it for emergency situations. My Derm says thats all I get. Needless to say I was bummed out to have the flush happen. The Rosacea forums suggest even smaller doses of Accutane for Rosacea. I have both acne and Rosacea so I am torn between low dose recommendations. I also had my upper lip go slightly dry. I used lip balm and wondered if I was imagining this (I mean I have only taken one pill for Gods sake) since it is one of the most common side effects listed for Accutane users.

I just took my second pill, I have chosen to take Accutane just before bed. If there are side effects I was hoping to sleep through some of them......more to come.

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.
8 Feb 2009
Brand:Sotret
Weight:90Kg=200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Supplements:None
New behavior: Lip Balm

Day:3
Well its official I tried caffeine again and I flushed within 3 minutes of drinking it. It appears that I no longer have the protection of Doxycyline and normal Rosacea symptoms have returned. I don't think the Accutane has caused any flushes, just normal triggers. I am for sure not imagining the dry lips. Only two pills and my lips are mildly dry. Its definitely noticeable. However, I have no headaches, no night vision problems and no detectable gastrointestinal problems. So far, I can't even really tell I have taken this drug other than the lips issue. I will take my third pill before bed tonight.

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.
9 Feb 2009
Brand:Sotret
Weight:90Kg=200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior: Zinc, Vitamin E, B and C supplements

Day 4:
Well its the morning of the 4th day. I have taken 3 20mg Sotret Acctuane pills. Slept like a baby, no sign of side effects other than the slightly dry lips. I am waiting for my acne to go crazy since I have stopped all antibiotics. I seem to be in a lull. Good! I don't want to post imaginary results but I gotta say I am waking up with less oil on my face already. Usually I am soaked. It would be hard to believe that this drug in only 3 pills could reduce my oil output already. However, if it can cause dry lips almost instantly then maybe a slight result could be possible already. I have no side effects other than the lips. No headaches, vision, nausea or pain anywhere so far. I have started to eat very healthy, low fat, grains and fruits are the route I am following. I am looking into supplements as well. I am thinking that a healthy diet and attitude might help with this therapy. I know that without antibiotics my acne should explode anytime now. We shall see.....

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.
10 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior: No soda pop of any kind

Day 5:
Well I took my 4th pill last night. I know it sounds crazy but I can see changes already. I have even more fear of this drug than I had in the first place. It has to be powerful to have these effects in the short term. I definitely am waking up with less oil on my face. My first day of work was met with 50 percent less blotting with tissues. I had several events where I felt I had flushed (rosaceans pay heed) under some job stress but checking in the bathroom showed just regular looking skin. My Acne has not burst forth in the abscence antibiotics yet. Pores seem slightly smaller already. The mild lip drying is still present. I have no reported side effects with the possible exception of the lip drying and maybe one other. My libido seems to have taken several steps backwards. It should be noted that all of the results I am reporting could be due to just coincendental factors. Inside though, I really think it is this drug. I have read other Accutane logs with similar results. I am trying to be very objective, I pay attention to small details. One other thing that is definitely happening is the anti-imflammatory effect. My skin color is more even and red veined areas are looking less apparent than they have in years. I realize this is only 80 milligrams of Accutane and the diet changes could be part of this...... I don't know. It seems impossible to already be feeling the effects of this drug, but my oil ouput and skin color has shown changes. I know, I have to look in the mirror every day. I will continue to log results, I expect the suspected effects to become more apparent as time goes on. Then I can report with more confidence what I am already suspecting. I remain mildly optimistic wondering about what I am experiencing. I am thinking of asking my Derm to reduce the dosage to 10mg.

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.
10 Feb 2009 Cont-
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior: No soda pop of any kind

I will be taking my 5th pill in a few minutes. I am still in shock that this drug shows effects in such a short time. Causes me to fear this drug even more. I will be asking my Derm to reduce the dosage for sure. He may balk, he was dragging his feet over the low dose idea. The sex drive thing put some real fear into me. I will be testing my libido regularly to detect any lapses. I hope my initial fears are in error, maybe self-fullfilling prophecy from all the negative posts on this drug. Well its show time.

:dizzy:
Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.


Ps. Thanks for the vote of confidence BabyNyc
11 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior:None today

Day 6:
Well, I will be taking my 6th pill in a few minutes. I gotta tell ya, you probably won't believe me though. My pores which I double checked with my Wife are reduced by over 50 percent. I was blotting 10 times a day with tissues to soak up oil. I now blot 4 to 5 times a day during work. My acne was under control from a year on Doxycycline, so I didn't have much when I started Accutane. However, by now I should be breaking out gang busters with Acne Vulgaris all over my nose. Ususally my nose is throbbing from the swollen sebaceous glands. It is feeling of normal size again. It actually looks smaller. It is like a switch has been thrown and my oil glands are being told to stop. My pores are shrinking at a rapid rate. A 100mg dose (20mg once a day) of this drug has caused these reactions in only 5 days. I say it again, I am very scared of a drug that has this powerful effect in that period of time. To the rosaceans who may be vieiwing this log, I feel extreme hot flushes in the cheek but not my nose, however when I check to see how bad it is, it is insignificant. I look mildly flushed compared to how I used to look. My side effects are extremely mild to none. Slightly dry upper lip is all I have..... I have read many horror stories about this drug, I won't go into the details. So, my fear levels are high. I am happy and at the same time scared to death. I really want to take even lower doses. I have considered getting gelatin caps and a syringe and drawing out 5mg doses to put in the caps. I wished this came in pill form so I could break them into pieces. I am not sure what I am going to do yet. It almost feels as if my body needed this, it makes me wonder how it works. Its like something out of whack has been corrected. Some individuals lives are ruined by this drug. I find that it is the high dosers who report the worst problems. Low dose this drug might just be heaven sent. My job is already one hundred percent better. My wife is throwing a party this weekend and I am actually looking forward to it. Miracle or curse......we shall see.:confused:

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.

Best Wishes
LowTane
12 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior:None today


Day 7:
I have had mild rosy cheeks and nose today every so often. Once for an hour or so. I do believe that the magic dose for my rosacea symptoms is probably lower. Most Rosacea forums report success with low doses. The trick is if you have both Acne Vulgaris and Rosacea to find a dose that is just right for both afflictions. Low dose studies show that 2.5 to 10 milligrams for varying sizes of people seems to work very well for Rosacea. Low dose studies for Acne seem to hover around 10 to 20 milligrams for varying sizes of people. I am going to ask for a reduction to 10 milligrams this month when I see my Derm. My skin is already looking better just because of the greasiness being minimized. Pores aren't so hideous. If this drug has this affect this soon, I wonder how fast things could go bad if I stopped taking it right now? The throbbing swollen feeling my nose has had for years is minimal now. Skin is dry and feeling smoother already. My wife has noticed the difference too. I kid you not, this is like a biological switch has been thrown. I have been waiting for the acne to explode, so far nothing. If I don't explode in another week with acne I will begin to believe that Accutane is suppressing the bacteria that causes acne somehow. Well for now I will stay on this dosage. It is so early in this trial that some readers must think I am nuts and imagining the results. I have considered that maybe I am just hitting one of those acne free windows and this is a coincedence. One thing I have noticed is the parts of my face that are not normally oily are very dry and smooth. My whole face feels tight. I am using Cetaphil on my cheeks. If my Derm won't go for a reduction in dosage I may move to skip dosing and take 20mg every other day. Well thats all for now, gotta go take pill number 7.
:wave:

Ps. I mentioned a Libido scare a few posts ago, well it checks out fine. (Well, for a 48 year old anyways!) ;)

Best Wishes
LowTane
14 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior:Optimism :D


Day 8 & 9:
Well its the morning of day 9 and I have taken 8 Acctuane pills for a total cumlative dose of 160 milligrams. I still take it at night before bed with a small meal. Well, I am in love with this drug, fear and all. Now, my face is never gonna be scar free without some intervention of some kind. I have had acne to long on my nose. However, Accutane is like a chemical facial. My pores are shrinking and my oil is more like a normal human at this point. I am in shock that this drug could be so rapidly effective. Blotches are already lighter than before and getting better as we go on. I can no longer even tell I am taking this drug. I have no side effects at all, not even dry lips. I have mildly insignificant micro flaking of the skin. So, inspite of the fear I am one happy camper. To Rosaceans, yesterday was flush free, and also, Acne Vulgaris seems to be in hiding. I have had a few minor pimples that have come out of the skin and been washed away. Now it should be noted that I have stopped a lot of other behavior as well. This could be helping the results along. At this point I can't really list a single problem. Now I know this could all go bad overnite so I am not going to get to euphoric and tell someone to run out and get on this drug. But I will say this, I will never take high doses of this drug ever. I made the commitment when I started that if low dose didn't work then tough luck. I have read at least 3 to 4 hundred hours on this subject. To many questions out there still even after almost 30 years of data collected on this drug. But I am hopeful that my derm may consider micro-dose long term if it will help manage my Rosacea and Acne Vulgaris. Low dose is the answer in my opinion. One more thing, the stories about diminished sex drive may be true, but for me so far that is not the case. All seems perfectly normal. Well thats all for now folks, I think I will take my (almost) oil free face out into the world for a few errands. Stay strong all............

Ps. Keep in mind that a lot more people have taken this drug than the horror stories support. If the several million people that have taken it so far all had very poor results I think this drug would be off the market for good. The reported birth defects seem to be the biggest negative factor that gets reported. I also suspect that the really high doses are causing the majority of problems where other side effects are reported. Purely an opinion from my personal research. Take it with a grain of salt, cuz I really don't know enough.

Best Wishes
LowTane :p
14 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily


Day10:
Well I suppose this log could get boring for individuals following it. To the Rosaceans reading this: I ate any an all forbidden foods and flushing seems suppressed. To the Acne crowd my acne is still in check with a few pimples here and there that are small and come out rather easily. The biggest change is the reduction in oil. That is undeniable...... with this reduction I expect comes the hopeful changes that make this drug irresistable. I can now at this juncture report that side effects are undetectable. Even the dry lips are gone. Sex drive is still intact. Eventually I will be a long termer who can report whether or not there were phantom side effects that pop up somewhere down the road long after I stop taking this controversial frightening yet wonderful drug. Hard to believe that it's a natural substance in our bodies and directly related to vitamin "A". I am feeling a lot better on this drug than the longterm antibiotics I had been taking. You can always tell you are on the antibiotics, but low dose Accutane is becoming undetectable. Well pill 9 was consumed last night and all is still okay.

Best Wishes
LowTane:wave:
Well Longhorn glad to hear from someone doing the same thing. It might be informative if you and I were to post our questions and answers to each other in this forum. That way readers (300 plus at this point) may gain from our experiences. My first question to you is what are your stats? If you could post those it would be great.

14 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New symptom: Itchy Face

Day 10 cont-
Well, I will make this short. I have just taken my 10th 20mg accutane pill and all is going well. No side effects of any noticable import. It seems my body has gotten use to it. My face is nicely itchy around my normal oil areas. The listed side effects: headache, nausea, bloody nose, cracking dry lips, lack of sex drive...etc.. have not occured at this dosage. My oil has been affected significantly. I have gotten a large portion of my life back in just 10 days. Pimples are showing up and emptying easily then drying out. I still may have a major outbreak coming, we shall see. I have been mildly rosy throughout, I am not sure if it really is Rosacea or some other reaction. I now do not believe I will ask for less of a dosage at my Derm appt. this month. Well I expected a horrible experience on this drug and thats not happening so far. I guess it could get worse. So far, I love it.


Best Wishes
LowTane:blob_fire
16 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New symptom: Sunburn easily

Day 11:
I went to play golf today and got red within one hour. I remember reading that Accutane makes you sensitive to sunshine (UV). Definitely sensitive, turned red quickly. Could be a combo of Rosacea and sunburn. Will wear sunblock from now on. No other side effects present. None.

Best Wishes
LowTane :p
17 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 12:
Well I took pill #11 last night. I am now getting acne on my chin and nose. I suspect the cessation of Doxycycline has allowed the bacterial populations to come back. Since Accutane is not an antibiotic I am bound to catch a few. They hurt...... Accutane cuts sebaceous activity and thereby reducing the food source for the bacteria that makes acne possible. It's hard to believe I am almost 50 and I am going through the trials and tribulations of a teenager. I will continue my regimen and play this game to the end. I hope this is the initial dreaded breakout I read about in other forums. Right now my oil is extemely reduced but not eliminated. Not on this dose and not at this time. I will continue to report changes in physiology as I experience them. I hope this helps someone out there who may be contemplating Accutane. I have calculated that the total cummulative dose of Accutane of 120mg per kg of body weight for best permanent remission opportunity would not occur for 540 days on this dosage. Something to talk to the Derm about.

Day 12: Cont-
Its time for pill number 12 here shortly. It should be noted that absorbtion can be increased by taking Accutane with a fatty meal. Hmmmmm...you can somewhat adust your dosage just by food selection. Well, the acne doesn't hurt as much as it did earlier. Its not very red either. Seems this drug is a wonderful anti-inflammatory substance. Face is still mildly itchy, lips are no longer dry at all. My face is better in just under two weeks on this drug than it has been in a long time. Well thats all for today. Pill #12 is on deck.

Best



Best Wishes
LowTane
18 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 13:
I gotta say, that Accutane changes the normal process for a zit. I was already for a long drawn out process for my new acne. It started very painful as usual, but.... my zits are drying up quick. Its as if they are drying from the inside out. Pain came and went. The normal expected redness and swelling is very mild in comparison to past acne events. Wow, I am loving this drug. Pores that I expected would need surgery are much, much reduced in size and appearance. Oil is still very well controlled. I have no side effects whatsoever. My attitude is improved 100%. After reading all the horror stories online I was braced for the worst. I might as well be taking a vitamin pill. I am thinking that the Europeans have it right. We are giving much to high of dosages in the United States of this powerful drug. Pill #13 goes down tonight.

Day 13: cont-
I just took pill #13 a few moments ago. I have two zits on the chin and 3 on the nose. They are not that red though. It really is a lot easier to deal with the zits on this drug. I hope this does not last for weeks. It would be nice to get past the intial breakout. To the Rosaceans. No flushing at all, no hot skin...nothing. It seems this drug does control Rosacea. The downside is I have heard it doesn't cure it like it can Acne. When all is said and done the next hurdle may be getting a Derm to commit to long term Microdose Tane. Well, good nite.


Best Wishes
LowTane:D
19 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip

Well my lower lip is getting dry, slightly cracked. Not bad, I am using lip balm again. The round of acne that I have is pale and not so noticeable. I still think the ant-inflammatory of this drug is amazing. It helps to reduce redness. Zits rotate pretty fast, come and go fairly quickly. I wish I had taken pictures of my face to start with.... sorry. Quite a few views of this log have occurred by numerous individuals. I hope this helps someone who may be considering "Low Dose" Accutane. The Accutane experience has controled my oil slick of a face very rapidly. Still no major side effects and the sex drive is still intact. No depression, no headaches, nothing but the desired effects so far. I realize this could all change, so I will keep reporting. Pill #14 tonight.

Best Wishes
LowTane:cool:
I started on Monday 2/16. I am 48, male,190 lbs and am on 40mg/day. My systoms are similar to your except I was on tetracycline for 11 years (absurd, I know) and everything else that did not work. My breakouts were usually not bad, mostly on the nose and trunk. My face started to get really read last October and it took me 4 months to get a derm appt. Since nothing else worked, including prescription creams, they said this was the best option.

I decided to quit drinking while I am on it...will make friday nights rather dull, but I like my liver.

The first day I had some mild headaches. The second day I broke out a little, but I`m not sure if it is from the accutane or the fact that I stopped using everything else. Today I was a little more broken out but they went as quickly as they came, which was strange. My eyes get very dry about an hour after I take it (with dinner) and that lasts for an hour or 2. My skin is less oily, for now. I sleep like a rock.

I was told to drink a lot of water and exercise and eat well.

My 19 year old daughter just finished up. She was never that bad but nothing got rid of her mild acne so she tried it and has flawless skin.

Good luck. Keep in touch.



[QUOTE=LowTane;3877069]6 Feb 2009
Hi, I have just taken my first low dose of Accutane
Brand:Sotret
Weight:90Kg=200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Supplements:None

Day 1
Chronic oily skin, blotting on the hour. I have mild Rosacea and more severe Acne Vulgaris of the nose and chin. My dermatologist in the USA had no real off label experience with low and microdose accutane. I brought him multiple studies from Israel, Turkey, UK and more.... he was interested. I have a back-up of Eythromyacin, I am hoping not to use it. I have been on Doxycylcline for the last year (this is not allowed with Accutane) since being diagnosed with Rosacea. My derm will only allow for a one month antibiotic security blanket. Eythromyacin does not have contraindications with Accutane, when its gone I have to ride it out. I am Professor at a local college, needless to say it is difficult to have skin problems and have to lecture in front of crowds. I hope I am lucky and can avoid the dreaded intial outbreak so many Accutane users report.

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do belive this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.[/QUOTE]
Well OldLawyer thanks for chiming in on this important subject. I hope all goes well for you.


19 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip

Pill #14 just went down the hatch. Same story... oil drying up. Zits come and go pretty fast. No side effects still. Good! More later...

Best
LowTane
OldLawyer absolutely do not stay in the background. Look how many viewers this thread has had already. Post your results so individuals who may take this option can compare more than one story. Any other individuals currently on Accutane please post as well. If you would, please list age, dosage, gender etc...

19 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip

Day:15
Well, I am starting to sound like a broken record probably. I blotted my normally horribly oily skin one time today. Unbelievable, normally I blot 8 to 10 times a day at work. This alone is cause for celebration, I am loving this drug so far. I am on very low dosage and obtaining these results. Still no side effects other than dry lower lip. I will continue to test the sex drive on a regular basis, (somebodys gotta do it) it is in the interest of science you know.;) Well pill 15 soon......


Best Wishes
LowTane
21 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip & Minor skin flaking on the nose.


Day 17:
Well this will be short, just the dry lower lip and the micro-flaking of the skin on the face. I know this is personal discussing the sex drive and all....but. When I was researching this drug before taking it I wanted to hear about it. Some people claim it destroyed their sex drive. Others said the symptoms persisted even after they had been off Accutane for months. So, needless to say I was scared. So far I have felt as though things were not going work properly a couple of times (yet things worked out). I am still concerned about this, it has never happened to me before. So, I am watching this very closely. I will try to report the outcome in as tasteful a way as I can. I am not sure if I have psyched my self out because of all the horror stories floating around on the web. I have been able to sucessfully accomplish the intended goal so far.....with some mental lapses. I will report any major failure if it occurs (cross your fingers)....................I hope it will not be an issue.

Pill #16 coming up.

Best Wishes
LowTane
22 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip & Minor skin flaking on the nose.


Day 17: Well this report will be a summary of events upto this time. I have experienced no significant side effects from this low dosage of Accutane. I am taking the Sotret brand. My lower lip is just barely dry. Every now and then I have a little piece of skin on my lip get dry enough to peel off with my teeth. This is rare, now this is significant. If you haven't seen what "high dosers" go through you need to go surf and read. Then again, I may not get the successful remission that high dosers may get. Now for the good part. My life has been so positively affected that I am shocked. My attitude, my willingness to participate in life. My students have noticed the difference, I am having fun teaching again. My personal space when talking to people has gotten to a normal distance again. I am not blotting during the day more than once or twice. I can touch my nose and my fingers don't feel greasy. My zits are coming and going at a rapid rate. My red blotchy appearance is showing a more even normal colored skin tone. Pores I thought were going to take plastic surgery have shrunk by 65%. My nose dosen't feel swollen anymore. My rosacea symptoms are non-existent. Veins in my nose have dissappeared. What can I say, I am hooked on Acctuane. My quality of life has already improved by 80% in just a little over two weeks on this miraculous drug. I can't tell you how this makes me feel, what an amazing experience it has been already. So, there.... thats how I feel today. I wished to God I had tried this drug a lot earlier, before I had so much scarring. Oh well... maybe laser will finish this journey off it I get a good remission. Well, folks...I recommend a low dose experience, even lower than mine. Possibly microdose will be the way of the future. 2.5 milligrams total daily. Like a supplement, who knows. Well, pill #17 is on deck. I will take it with milk to increase the absorbtion. It is fat soluable..............:p


Best Wishes
LowTane
Old Lawyer, I am glad you chimed in...please do keep us updated. My wife and I were looking at my pores tonight. Honest to God I am in shock, my wife told me that I have no pores left. I had holes in my nose, I was checking into plastic surgery. I have also put alcohol on a shelf, maybe for good. I feel like drinking may have caused some of my Rosacea issues. I feel great and have lost weight by cutting out the weekly drinking. Good ta hear from ya.......:)

23 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptoms: Dry lower lip

Day 19:
Well, the pores are shocking, the oil is gone. Sex drive still seems functional, but the fear subsists. I don't know what to say, I am blown away. My Rosacea symptoms are non-existant. My attitude has just gotten better by the day. Wow, you probably think I am nuts! If I had known this option existed before, I would have stepped up to the plate a long time ago. 20mg daily has made a huge impact on my oily greasy face. It feels great to be off of antibiotics. I know I am repeating myself but I don't know what else to say. An ugly vein in my nose has all but dissappeared. I am waiting for the other shoe to drop. Acne scars are less apparent. This may be because of the lack of oil, scars and imperfections show up much better when coated with shiny oil. It also could be the tightening of the skin. Pores have closed up at an incredible rate. Its funny, now I can only think of the end of the thearapy and what will happen if I don't get the remission. Well, I should get 10 months minimum out of this, thats how long my derm has me scheduled for........ Pill #18 down the hatch.:bouncing:


Best Wished
LowTane
Thanks Blueyz..........

24 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptoms: Dry lower lip
Behavior: Cetaphil soap and moisturizer b4 bed



Day 20:
I never did use the emergency Erythromyacin my Derm gave me for the intial outbreak.
No side effects other than lower lip slightly dry.
Sex drive still functional.
Micro-flaking on nose and chin (only the areas where acne presents).
Oil reduced 95%
Rosacea symptoms = Zero!
Acne breaks and drys in 24 to 36 hours.
Pores and scarring have been affected significantly.
Confidence has improved 85 percent.
Fun factor and socialability improved beyond measure.
Pessimism diminished somewhat. (Still I do not take this drug lightly!)

Pill # 20 is on deck in one hour! :wave:

My take and speculative wishful thinking: I honestly am starting to feel that this drug at this low dose is not going to kill me. I have 100's of hours (really I do) of reading blogs and research papers on this subject. I think that the high dosage approach is where the problems can really present themselves. Even though some individuals report no problems in the long term from higher dosages. I don't think I would be comfortable on this controversial drug at the 5mg/Kg of body weight norm here in America. My hopes are at the very worse, a 5mg every other day maintenance dose (or less) in the long term if required. I am aware I could still have problems in the long term. However, this drug is 30 years old. Millions have taken it, wouldn't this be a much bigger story if everyone had long term side effects. The web shows a small group of individuals (in comparison to the number of individuals who have taken this drug) blaming this drug for every bad experience they have had post Accutane. I am not saying they are wrong, I am wondering if they are just a small percentage of a very large group. Just a thought..................

Best Wishes
LowTane

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long and short term side effects.
Thanks for the update OldLawyer, very informative. See below for recent event:


25 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptoms: Dry lower lip
Behavior: Cetaphil soap and moisturizer b4 bed

Day 21:
I hate even reporting on this subject but I gotta. This affects both people in a relationship. I had noticed some sensation changes with this drug during intimacy in the very first days of usage. In my last encounter there was failure and I did not bother to try and finish the event. Now, you should know to put this in context that I am 48. However, this does not happen to me. I am and always have been right up till I started taking Accutane as regular as a clock, 3 to 4 times a week. What I also noticed, and maybe this is more frightening than the failure is that I didn't care. Normally, interruption of this event would cause extreme frustration. In this case it didn't bother me. You don't mind passing up a meal if your not hungry. This is significant, I am very prolific and have been my whole life. So, lets think about this. There are reports and possibly lawsuits because some people are reporting that the loss of sex drive continues even after the drug is stopped. It does make some sense, individuals taking this drug hope for remission. Meaning, after you stop the drug the benefits persist. The exact mechanism for how this drug works is not known. Oil production (the chief cause of acne) has been tied to testosterone and estrogen, which are also tied to sexual appetite. So if there is remission and longterm suppression of acne it stands to reason that suppressed sex drive could also be a result. Of course this is unprofessional layman speculation and should be taken with a grain of salt. It is to early to tell if this was just some mental event, its possible I suppose. I am very self aware though and know my body very well. I will test this out with stronger stimuli and see what the results are (I can't go into details here I am embarrassed to even be writing this as it is) after that experiment. If you surf up Accutane and sex drive, impotence etc.. you will definitely find results. I hope to give you the most accurate objective observations that I can. So, at this point I must say that I am very concerned and have some serious thinking to do. I will monitor this trend closely and discuss it with my Derm. I will continue to report to you as accurately as I can my experience on Accutane.

Note: If you are reading this, please don't jump to conclusions yet. All people respond to drugs differently. Women and men will have different attitudes about this observation. Some individuals report no problems with sexual activity while on or post Accutane.

Update: Read ahead, possible false alarm on the impotence scare.

Best Wishes
LowTane :(
25 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 21 cont-
Allrighty then...... update on the sex drive post. Now mind you my moral beliefs prohibit some things. So this is tough for me.. Further attempts to utlize my natural processes met with success. I will continue to check on this capability throughout my Accutane course and after my prescription is complete. It is possible that I have read far to much material regarding the usage of this drug. I may be psyching myself out. Intimacy is such a mental event. It should be noted that 5 million people have now taken this drug. You would think there would be more on impotence if it was prevalent. I still do believe that individuals that have reported impotence are telling the truth. Things have changed in my body. I may have psyched myself out or maybe not. To early to tell. If you are following this thread you should also remember this evidence is anecdotal at best, and the reported experiences of just one person. I am not a health care professional and have had no formal training whatsoever. So, I will just try and be honest with what I experience as it happens. I will continue to closely monitor this aspect of this therapy. I apologize if I have offended anyone, I am trying to be as discreet as possible for both women and men who may read this thread. But, hair falling out, impotence, depression and a myriad of other side effects reported by individuals who have used Accutane warrant this level of reporting. The issue is not temporary impotence, its permanent impotence that has me freaked. Some individuals have reported this effect even after stopping Accutane. I don't trust big pharma or doctors implicitly. My wife and I value our intimate relationship and I don't believe I wish to trade it for a clear face. So hang in there, I will report daily to the best of my ability any notable changes that may occur. So for now the libido outcome is still on hold.

Ps. My wife says it looks like I had a nose job, I didn't realize how swollen it was from all the excess sebaceous activity.

Keep the faith!
LowTane :p
25 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptoms:Lower lip is a lot dryer than before. Cracking a little now.

Day 21 cont- cont-
Well pill # 20 is on deck pretty soon here. I thought about the implications of the possibility of permanently losing my libido all day. I had read posts where it had been reported. So, I am kinda freaked. Things are still working so far. I will probably quit this drug and back track if I start to have numerous negative events. I will ask my Derm this month about what he has heard. I don't expect much feedback on this subject. Roche does not list this as a side effect and most people are squeamish about discussing libido. I guess I had two big fears going into this, losing my hair and my libido. My research cemented these two as my biggest fears. On the other side of the coin, damn..... I am loving my face. What a great break from the oily mess I had. I feel human again. I would like to remind anyone following this thread that I am type "A" all the way and have a tendancy to over analyze. This has its plusses and its minuses. I will observe the smallest detail and try to figure it out. If I finish this course of Accutane I will continue to report so that individuals may benefit from my experience. If side effects surface after therapy I will post the experience. I hope this helps someone out there. I feel like a human guinea pig. Wow! My face is great. I am blown away and yes still scared out of my wits at the same time. I would like to ask anyone else out there to post any changes in sexual behavior they may have experienced on this drug. Good or bad..........


Best Wishes
LowTane :cool:
26 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptoms:Lower lip is a lot dryer than before. Cracking a little now.

Day 22:

Applied carmex to the lower lip and it worked like a charm. Face is now almost 100% clear. Blotches are fading and oil is gone. I am happy to say that all biological processes are working just fine. My blood test is coming up quick I am hoping cholesterol and triglycerides are acceptable. Can't forget liver enzymes too...... I am thinking that maybe the libido is going to be okay. I think that I have never been so concerned about a medication before and it may be causing some over reaction to normal events. We shall see. All of the horror stories on the web have impacted my psyche. I need to keep this in perspective. 5 million users, less than a hundred examples of web posts discussing permanently lost libidos. I hope I haven't freaked out any potential Accutane users at this point. If I did I apologize, if things do fail in the future I will try to alert blog readers to the problems in a sober manner. I will closely scrutinize all aspects of my body during the entire Accutane regimen. I will keep you posted.

Best Wishes
LowTane
Well OldLawyer, thanks for the comments. I am jumpier than a longtailed cat in a room full of rocking chairs over this medication. I mean its just a fact, Accutane is controversial, period. I gotta say though, wow! What an amazing job it has done in healing my tortured schnoz and chin. I still blot out of habit sometimes, minimal oil is present. My nose is very narrow now. Still healing a few places and blotches are dimming. Luvvin it..........!!!!


26 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptoms:Lower lip is a lot dryer than before. Cracking a little now.

Day 21:

Well pill 21 is on deck, I may have messed up the count in prior posts. I am done freaking out for now over my private intimate life. For now..... Face and confidence are on a parallel path. Life is better than it has been in quite sometime. Dry lips are easily handled. No other side effects can be detected. Sleep just fine, no headaches or body aches like some individuals report. No night blindess whatsoever. I am really happy with the results. If there is no final potential price to pay for this amazing miracle drug I will be extemely greatful. I see people on the streets and in the classroom that have oily skin and blotchy painful looking acne and I want to say something to these people. Like "Do you realize you could possibly be completely clear of acne in less than a month?" Then I think about the controversy surrounding this drug and I keep my mouth shut. I can't recommend this drug because it scares the crap outta me............. I can report what I experience though and hope individuals that decide to use this drug based on what others say still realize it could turnout bad for them, regardless of the success others may have. Thats the bottom line..........

Best Wishes
LowTane
OldLawyer, good to hear from ya.... thanks for chiming in for Drew. Its good to hear results from more than one person. Thanks for sharing the details of your therapy.

26 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily


Day 22:
Well, I have realized that I will get to a point where my face will not advance any further. Once the Acne is gone and the oil has dryed up the only thing left will be scars. At this point my reporting will only consist of observable physiological ramifications that may present during the completion of this therapy. The next phase of interesting material may consist of posts logged after Accutane therapy is complete. Will there be a remission? Will OldLawyer's more conventional dosage get him a remission? Will my Rosacea symptoms come back while the Acne stays in remission? Will I become impotent? Will other long term side effects present months or years after suspension of Accutane therapy? Like my hair falling out as some individuals report. Or, is my Dermatologist correct with 20 years of Accutane experience when he says "poppycock?".......Will I need and Will I be able to talk my doctor into long term ultra-lowdose acctuane? If he does, will it help me to remain oil and rosacea free? Like say 2mg a day, 1/10th what I am taking now. Will the return of my youthful dashing good looks cause me to trade my wife in for a younger beautiful woman? Will I get Laser Genesis to erase the remaing micro-scarring? Or, will an asteroid hit the planet making all of these questions moot? More importantly, will I break 80 in golf? Well, I am rambling now. These are questions that my abstract musings produce over time. On a serious note, as I walked down the hallway at my Dermatologist office I heard him say over my shoulder "Accutane will change your life". I looked back him and I thought, I'm worried about it ruining my life. So here I sit looking at my new face thinking, regardless of the fear factor here, wow!, this drug has changed my life, it has for now given it back. I haven't been this happy in a long long time.

I will take pill 22 in about 30 minutes.

Keep the Faith
LowTane :rolleyes:
28 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 23 and Pill #23:
Well, if any of you have been following this Accutane log you know by now I am an obsessive compulsive type of individual. I was agonizing over a momentary lapse in Libido due to all the web stories pertaining to that issue. Well I am happy to say that everything is normal, no problems. You can bet that if things go south (no pun intended) I will report those results. I did have Rosacea type flushing of the cheeks today following a dcaf latte. But I have also taken to having a 4 ounce glass of Cabernet Sauvignon before bed. I am wondering if either could be the cause of the flushing today. The Acne is in complete remission, I am luvvin it...........My nose is so narrow its hard to believe. I still have a few minor blemishes trying to fade away, but no new ones. I had a few minor blemishes on my back and they have dried up. Flaking of the nose etc... Well time for #23 and bed.
Likewise Nikki, I wish you the best of luck. Thanks a ton for bringing up therapy for Acne I had never heard of..........
1 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 24:
Pill 24 on deck, not a ton to report other than a few zits arrived and exited fairly quickly. Oil is still highly contolled, no side effects I can perceive easily. Little flaking here and there, lower lip etc.. I am definitely thinking already about the end of this therapy. I feel like the low dose over the longterm is easier on the body than the higher doses. Its hard to tell at this point that I am taking a drug at all. Rosacea with slight flushing here an there, but no papules or bumps anywhere. Pores have shrunk a lot, it will be interesting to see if they can even shrink more. Libido, check.. all good. I will continue to report as long as I can find something to say of substance. I feel like this is just a repeat at this point. So, I have taken to try and post something to read that may be meaningful. Well, its time.....

BestWishes
LowTane
"Generally accutane is introduced at a very low dose and is steadily increased over many weeks. There actually are no specific guidelines as to how much should be prescribed to each person. However, research shows that a total dose of around 120mg per kilogram of an individualís body weight is enough to banish acne for some time. "

OK, well if I do the math, I will need to take about 10,300 mgs to be "cured." That would be an average of about 57.25 mgs per day for 6 months. I am taking 40 mgs per day now, and I know I won`t be on that level for the 9 months it would take to reach optimum dosage. My guess is I will do a few months at 60 to 80mgs per day once the docs confirm my body has tolerated the lower dosage so well. My daughter, who weighs 110, did most months at 20mg and a few at 40mg, when the 20 stopped showing improvement. They cut her back down to 20mg before she finished.

Anyway, I go back to the doc in 2 weeks....bloodtest next week. I assume I will be ok with blood levels and enzymes. I am not ready to drink alcohol yet, because I don`t want to risk a bad test result (oh yeah, or my liver). At 14 doses in as of last night, I figure I am about 1/12 there! I am measuring this ride in terms of days, not mgs. I truly believe that within 30 days my skin will be completely clear and virtually oil free. If it takes another 4.5 months to keep it that way for a long time, then I will be a happy guy.
Good to hear from ya OldLawyer....Thanks for the input. Your musings are like mine. Even at a conventional dosage of .5mg/kg body weight ratio I wouldn't reach the vague pseudo cure dosage of 10,800 milligrams for around 250 days at 45mg. At 20mg we are talking 540 days or 18 months. So even my Derm has me scheduled for less than the recommended cumulative dosage. Unless he decides to keep going after we get to the 10 months he has me scheduled for.........Questions I will pose for him when I see him. Blood test is tomorrow.


2 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Well pill #25 is up and coming shortly. We got one medium doser and one low doser same age and weight on this board. We are both having amazing results with no real side effects. What have we learned. Well, both dosages are working. What will happen when we end our therapies? I don't know. Only one way to find out, we gotta finish this thing. I am in the same condition, none to moderate oil, libido works, and minimal skin flaking. Thats it for now. More to report after my appointment this week.

Best Wishes
LowTane
No prob Nik, I found the material very interesting indeed. Thanks for sharing.

3 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day26:
Blood test is done. I have an appointment day after tomorrow for my 1 month follow-up. I will ask some questions about dosage thats for sure. Well I hope this is helping anyone who wishes to monitor someone else's therapy b4 taking the plunge. I have my hair, and libido..... No bloody noses and vampire lips like some get on the higher doses. No thoughts of suicide or depression. No loss of night vision, no insomnia or nausea. Really, I can't tell I am taking this drug at all. Other than the loss of oil and the shrinking pores. Pill 26 is going down the hatch shortly. More to come..........

Peace
LowTane
[QUOTE=LowTane;3906229]No prob Nik, I found the material very interesting indeed. Thanks for sharing.

3 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day26:
Blood test is done. I have an appointment day after tomorrow for my 1 month follow-up. I will ask some questions about dosage thats for sure. Well I hope this is helping anyone who wishes to monitor someone else's therapy b4 taking the plunge. I have my hair, and libido..... No bloody noses and vampire lips like some get on the higher doses. No thoughts of suicide or depression. No loss of night vision, no insomnia or nausea. Really, I can't tell I am taking this drug at all. Other than the loss of oil and the shrinking pores. Pill 26 is going down the hatch shortly. More to come..........

Peace
LowTane[/QUOTE]
Hi LowTane
Just a quick note to say how grateful I am for your posts - very informative and entertaining! Quick note about my progress...currently on day 12 of 20mg per day and things are looking good! The flushing that i experienced between days 5 and 9 have subsided and i have only a few little spots on my forehead. The pores on the rest of my face have definitely shrunk - very impressed. Minimal side effects just the usual dry lips, but nothing a good dollop of vaseline doesn't sort! Thinks that's about it. Probably going to reduce my dosage to 10mg per day when i get to the 30 day mark - see what happens there...
Cheers and keep posting!
OldLawyer LOL... Talk about hitting the nail on the head. Man I am keeping a close eye on this libido thing. I have never really had to come to terms with the possibility of losing it permanently. I still have a roving eye and my wife is wondering if I am in my second childhood. I want to test it often, which is putting me over my normal schedule. She's telling me "its fine, enough already"..... I am happy to say to all of you potential taners out there that everything still works.

5 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

I did my bloodtest day before yesterday and I have my appointment with the Derm in a couple of hours. I am virtually blemish free and oil is no longer a problem. My back had a few blemishes, now gone. I feel relaxed and better than I have in such a long time. Life goes better without the trauma of facial acne and Rosacea. Nose is narrower and no longer throbbing with over active sebaceous glands. I will ask my Derm about the future, cumulative dose plans etc.. I have no real side effects at this point. Slightly dry nostrils, very slight and mild micro flaking of the nose. The flaking is not even noticeable unless I scrubb to hard or wash my face to long. I use cetaphil moisturizer to shave with, apply it to my nose as well and leave it on when I exit the shower. So for now, life is okay. I have taken to having a 4 oz. glass of Cab Sauv once in awhile before bed. I drink more tea than anything and I have cut soda pop almost out of my life. I did my 27th pill last night and slept like a baby. Attacked my wife this morning, just to make sure!!! All is well for now. My hair is not falling out either. More to come..... after the Doc Appt.

Best Wishes
LowTane
OldLawyer, I know how you feel. My life and my attitude have just gotten better because of this highly controversial drug. I am glad for you to be able to go out and have the nagging nusiance of Acne off your back. Right on! Good for you.....

5 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily


Day 28 or somwhere close:

I went to the Derm and he was happy with the results. He has been working with Accutane with great results for years. He told me its possible to get a complete cure from this therapy. He doesn't however have high hopes that I will get one. He said most people get remissions, but not complete cures. At least in his experience. Now all this guy does at this clinic is Accutane. Thats his primary job description. So, he is the Accutane Doc at this clinic. He shocked me by saying he would like to take the dose lower after this next month of 20mg daily. I thought he would want to go higher. He wants to see how low we can go and still get the job done. He mentioned that most people end up doing Accutane more than once. I got the feeling he thought that if you have to do Accutane more than once it would be better if it were on lower doses. I agreed! In the old days some people were put on insane dosages of 80 to 100 miiligrams daily (and still are) with the idea that higher dosages gave a better shot at a cure. Studies in multiple countries have shown that low, medium and high dosages have resulted in longterm remissions. It affects different people in different ways. My Derm mentioned that he currently had one guy on one pill a week. He didn't say how much. If he goes off that pill he immediately reverts to his pre-acne state. So, to make a long story short, this blog may truly turn into an ultra-low dose blog after next month. I got the feeling we will stop this drug for sure. If I revert to my old state I will need to go back on Antibiotics. After a period of time of an un-specified length my Doc would let me go back on the tane...... So for now I am enjoying the lack of oil and zits. Now mind you I still have scars and some holes in my nose from prior bouts with Acne. But man, do I look a lot better. I just look kinda rugged and tough, yeah, yeah thats it rugged and tough. Well somehow I got a hot wife, so I guess I can survive the look. Well thats all for now folks, pill 28 is on deck in about 6 hours. Stay strong all. Just know this, Accutane works. Low dose might be all you need.

Best Wishes
LowTane
6 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 29:
All extremely interesting OL. I started to have gastrointestinal problems from a high stress job coupled with poor diet. Diet sodas had replaced water and alcohol was a weekly event. Rosacea surfaced right on cue with the gastro problems. Many Rosaceans report the same thing, gastro first Rosacea next. Who knows, its all anecdotal....could simply be age. Well on another subject I have had some possible side effects today. A headache that lasted all day and some strangely weird wooziness and head scrambling. I had to cancel a lecture give a takehome test which tickled my collegiate captives to no end. The headache left after a good size meal and 2 asprin. The more I read about this drug the more I fear it. To many times I have read " the exact mechanism for Accutane's success is unknown". This drug has been out for 27 years. It is the number one selling drug for Roche. I have read as many as 5 million have taken this drug. It has been considered for removal from the market by the FDA. Debates have been fielded on the congressional floor over this drug. I think I am wise to be fearful. What scares me is the articles that discuss the permanence of the side effects. I for one cannot wait to get my dose lower. I have considered skip dosing, but I am afraid I may not get a long term remission if I play ping pong with the plasma levels. I don't know who reads this, but these are the things I think about.


I don't know if this helps anyone reading this blog. I can say this, my face is better than it has been in years. It feels great.....I just wonder will there be an ultimate cost. Google up side effects and lawsuits and Accutane before you even think about taking this drug.

Pill 29 on deck, maybe..........

Best Wishes
LowTane
[B][/B]7 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 30:

I took pill #29 last night. I have been reading horror stories all day off and on about this drug. I am having minimal side effects. I am still wondering if I should abandon this drug. I am thinking of skip dosing with two pills 20mg x 2 times weekly. To see if the dry oil free skin stays in place.
I may be taking a break from this drug to assess my feelings.



Best Wishes
LowTane:confused:
8 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily

Day 31:
So, I skipped pill number 30. I have decided that I wish to take the minimum amount of this drug. I will be taking 1 pill every Friday night. I am 100% clear after one month on this drug. I have decided that my sex drive is slightly dampened but functional after the 600mg that was ingested in the first month. I will bump the dosage from there if needed until I arrive at the minimum maintenace level required. I had another all day headache, I skipped a dose and the headache was gone the next day. Since the Derm has mentioned a second round of this drug as a matter of doing Accutane business I am not concerned about getting the drug. I guess this is what I really wanted all along. I decided to take charge of the dosage since I am the one that will have to pay in the long run. My Derm told me he has one patient taking one pill a week which shocked me. He didn't mention it before. Multiple studies address the efficacy of low bi-weekly dosing as an effective way to maintain and acne and Rosacea free state. It will take a lot longer to reach the total cummulative dose this way, but I feel starting low and moving up is better than starting high and moving down. I have found just to many horror stories and they have started to affect me. So, if were gonna go low lets go low and prove something. If I get a remission after an even lower dose regimen and I do it with the minimum amount of this horribly controversial drug the better. If I don't I can always go back and do the the the higher dose regimen if need be.... I probably won't though. Losing my bowel to Crohn's disease (the latest lawsuit by the way, just surf it up) kinda got to me. Until I get over that I am gonna have back off on the dose levels of this drug for mental satisfaction. We all know that Accutane at doses as high as 120mg's a day have been reported. We all know that Accutane clears horrible cases of Acne and changes lives. However, you gotta read the "Ask a Patient database" and read the 393 patient reports on this drug. I have major concerns..... More to come.............

Best Wishes
LowTane
Good to hear from ya Chooch. Thats cool.. Its nice to hear from other low dosers. But I must ask, what was your outcome after your accutane experience. Success, failure? Will you take it again. Did you have a remission etc... it would be cool to hear your story.

Old Lawyer, good to hear from you. You are right, there are side effects listed for every drug. There are lawsuits for multiple drugs on the market. Also, the sampling of horror stories is small in comparison to the number of patients who have prescribed this drug. I had wanted to go with a very low dose all along to feel this drug out. I know that long term antibiotics are no option either. I am torn between long term extremely low dose maintenance accutane and going for the high dose and hoping for a really long remission. I have skipped two pills so far and my headache and dizziness hasn't resurfaced. Could have just been a fluke and had nothing to do with Accutane. My derm is going to lower my dose next month anyway. So, still contemplating my next drug move. I do appreciate your reply. Good Luck...

9 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days.

Day 32:

Well if you have been following along at all you know I am taking liberties with the dosages of this drug. I have backed off on the 20mg daily to 20mg every 4 days. I have no increase in oil yet from the lower dosage. I have felt better on the lower dose. My facial redness (flushed look really) is more normal skin tone now. I am still dry and have very mild flaking. I am 100 percent clear and my pores have shrunk 85%. I am loving this part of this, all things are better. I do believe some of the extremely high dosages doctors have prescribed some patients have really caused some terrible problems. My reading shows that a lot of people get remission but still come full circle back to acne and oil. Many people do this drug several times with long breaks in between. My goal is to go low and stay low and check out my results compared to hopefully someone on higher dosages. Maybe old lawyer will stay around long enough to be that guinea pig. Well all for now......


Best Wishes
LowTane
10 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days

Shidoshi, thanks for giving some details. I have dropped my dosage as everyone knows if they are following this board. I am down to 20mg every 4 days. I was going to drop to 1 a week but changed my mind. So right around 2 a week it is.. At first I had no side effects at all, and I am not sure that the things I am experiencing are related to Accutane. Dizziness and balance problems, just slight but noticeable. Also, articulation and short term memory have had some weird lapses. The good that has happened is that I have become 100% clear with 30 pills which equals 600mg in just one month. I have been blown away as to how tortured my sebaceous glands were. Not only has Accutane shrunk my very large pores, it has caused spider veins to disappear as well. I also think a very large part of what I am going through now is directly related to the modern industrial diet. I am trying to change those things now. I have stopped drinking soda pop entirely. I drink more water, I have cut out sugar and almost all alcohol. Caffeine is gone. I am closing in on 50 and I hope that I can reverse years of damage through diet, lifestyle and maybe this drug. Well I may have screwed up the count, but I just took pill thirty. I will keep you posted as time goes on. I know this can get boring at this point. So, I would love to try to get you readers to share your Acne or Rosacea story and find out whether or not you have tried Accutane. Please join and log in an and share your information with us. Lets get this board growing, with almost 3000 views in one month you would think more of ya would stick around and share some information. Please do, it has been extemely helpful to me when individuals share their stories. Well, thats it for tonight.

Best Wishes
LowTane
11 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days

Chooch, this low dose study done in Israel came up with some significant remission rates on low dose Accutane. Also, I have found many individuals who have taken high dose had their acne return. So, I am not sure what to make of it. Many doctors in other countries think the Americans prescribe too high of doses. Many researchers believe that it is the total cumulative does that counts. Low dose avoids the chemotherapy burn your oil glands to a cinder and hurt the rest of your body approach. The following study was conducted over a 4 year period. Read this and see what you think...........

To everyone else, I can vailidate one of Chooche's observations. So far with a pill every 4 days no oil, no acne and no real problems.

I removed this article to be in compliance with board rules: Google the following to find it.....

Israel: Low-Dose Isotretinoin for Acne Vulgaris
12 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days

Chooch, heres the part I am talking about:

A total of 617 patients completed the study. In group 95% of patients achieved considerable improvement or complete remission of their acne;

Somewhere in that 95% were low dose Accutane users who acheived complete remission.

Where low dose is concerned my thinking is that the lower doses cause less damage to vital systems. I could tolerate a minute amount of strychnine once a week for a long time. However, a full cup would kill me instantly. I know that analogy stinks but its all I could come up with on short notice. Since the actual mechanism that makes Accutane effective is unknown, I believe it warrants extreme caution. I know there are quite a few individuals out there wishing they had never seen or heard of this drug. Many other countries are reporting responsible long term usage on much lower doses. I believe it is prudent and wise to re-think western methods. Many blogs report high dosage acne relapses. If someone starts on low dose, they can always later on try a higher dosage. At least they had time to feel out the drug and see if they can gain complete remission without as high a risk. I only posted two studies, there are more from Germany, UK, Turkey, Israel, Sweden etc... They are all advocating therapies that involve lower dosages, for very good reason I believe. So, for me, I feel much better trying the lower dose regimen before committing to a higher dose regimen. I certainly wouldn't recommend this drug to anyone without caution. I am 100 percent acne free on my entire body, with extremely minimal side effects thus far. I am maintaing that condition so far on 20mg's every 4 days. I bet based on how my body feels, that I could do it on even less. I intend to try and prove that point in the very near future. Dr. Plewigs study suggest some individuals maintain an acne free state with as little as 2.5mg's twice a week. To be fair, it is working for people with mild to moderat acne, I don't see a lot of low dose reports for really bad cystic acne. This drug completely cleard up my nasty oil acne riddled skin in one month. I am blown away. I had to take in 4 different studies which I printed out and show my Derm before he settled down to the idea of low dose. Now he seems to be fully on board with the idea. We could do American acne sufferers a big favor if we would all do the same thing. Educate them thar Doctors as to what the foreigners are up to with this controversial drug called Acctutane. Some Doc's may listen.

Well, enough conjecture for tonight.

Ps. I would rather take this drug for 8 years safely and remain acne free, than taking high dose for 6 months and possibly suffering from side effects for the rest of my life. However there are no real long term studies on low dose Accutane either. It could be just as risky.

Best Wishes
LowTane
14 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days

Well I could see how you could get bored reading these boards. I am still marching along with the low dose Accutane. I started with 20mg a day and cleard my skin, shrunk my pores all in one month and 600mgs. I have since reduced my dosage to 20mg every 4 days. I am really tolerating the lower dose scheduling on the 4 day cycle. Sex drive definitely is different. Things work, but the miindset has been affected. I am not sure what to make of it. Oh well only time will tell. I will lower the dosage further after the next Derm appt. I am still very wary of this drug, but man, wow.....what a difference in my life it has made. Confidence, attitude and appearance have all improved. I am way happier. My pores have shrunk, my blotchines has evened out, skin is soft and taught. Just didn't realize how swollen glands and hyperplasia can change your appearance. Well, thats all.

Best Wishes
LowTane
14 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days

Well Chooch, I am only guessing here...but I don't think lifting weights will increase testosterone levels much. But what the hell, it couldn't hurt to try it out. Now the supplements, thats not a bad idea. Hopefully whatever you choose will not contraindicate with the Accutane. I am able to get around the damped libido effect with an adjusted mental attitude.

Shidoshi, you couldn't be more correct about helping Accutane therapy out. The modern industrial diet has provided us with many new diseases. One look at nature and we can see that proper diet and exercise keeps the animal kingdom acne free. I have cut out soda pop entirely. I have cut processed sugar to the absolute minimum. We are held captive by the shelves at Safeway. Unless you can grow your own food and hunt regularly you are basically screwed where sodium, sugar, cholesterol and fat are concerned. On your pores, mine have been giving up little hard spicules that come out when washing or just gentle rubbing. You may be shocked at just how tight your pores will get. Unless you have taken this drug before. I can't remember if it was you that posted this is your second time on Accutane.

Well good luck all, time for work unfortunately. I will keep plugging away with the lower dose regimen. I intend to go so low my Acne returns. I am flirting with the idea of longterm micro-dose. If I can stay clear on 2mg twice a week like Dr. Plewig's study suggest, I might try it. I have already noticed that 20mg every 4 days instead of every day has improved my libido.

Side effects minimal, definite slight damping of the sex drive. Extemely mild headach once in a while. Lower lip slightly dry. Thats it as far as I can tell...

Still 100% clear, with oil at an absolute minimum with just over 600mgs and only 40 days in........ unbelievable.

Best Wishes
LowTane
16 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 4 days

Good to hear from ya OldLawyer, I am glad all went well at the Docs. On the internet thing, most Doctors will say the same thing with the web reading. I tend to agree to a point, but doctors are people and they are fallable. I don't believe they are perfect in their overall outlook on many things. They do however run businesses, and that in itself is an issue. You probably have run into self appointed lawyers and have the same reaction. But, the web is an incredible source of information, anecdotal yes, and produced by lay people with no formal professional training. Its all true. My case in point would be this, either your Doctor just hasn't heard of this side effect before or the multitude of individuals who report loss of sex drive after engaing in Accutane therapy are wrong. Someone has to be right, only one or the other can be true. I can find lots of people reporting this side effect. It is possibly a rare side effect in comparison to the millions who have taken Accutane. To give her credit, she probably just hasn't run into it before and believes it is not a valid side effect. I can accept that, doesn't make all the individuals reporting this side effect wrong either. It has definitely affected my libido, which is something I am very tuned into, it is slight but noticeable. As long as it isn't permanent I have no problem with this effect. It's not uncommon for many different drugs to effect libido. Albeit temporary..... Many individuals support this finding in multilple places. The web has its place and for the most part Doctors are right in suggesting that you should take web reading with a grain of salt. However, Doctors learn most of what they learn about drugs from patient feedback. Studies conducted on drugs also rely somewhat on patient feedback. The same type of feedback that is posted by every day regular people on the web. So, in the end, it is a mixed bag of nuts. Doctors in the past never had to face patients armed with so much information, some reliable and some not so reliable. My Doctor prescribed my wife Ambien and her throat swelled up and she had trouble breathing. Ambiem reported this side effect on their website as anapyhlactic shock. They suggested discontinuing the drug immediately. My Doctor who had been prescribing Ambien for several years had never heard of this side effect before. He knows now.......

I remain cautious but optimistic about this amazing controversial drug. Everyone is different and may have different side effects.

Best Wishes
LowTane
17 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 7 days

I have changed my dose to 20mg once a week. I am flirting with failure to see where my tolerance is.......... I do not feel strange about this experiment. I never ever wanted to take this drug in high dosages. I actually started higher than I wanted because the Derm set the dosage and i went along with it. Now curiously he would like to go lower. I think he is enamoured with a patient he has who takes one pill a week. He didn't suggest the dosage for this patient "X". I will ask him about it next visit. Very little has been done in the way of low dosage therapies in the United States according to my reading. Since I have backed off on the intial dosage I have even less side effects, lower lip, dampened libido, etc... I am 100% clear and my pores have gotten about as small as the poor stretched out things could get. It has been a significant improvement. I have decided to ride the extreme low dose experiment to the end. If I do not get a remission I will take a break and do a higher dose regimen possibly. I am not sure, as my opinion of this drug at higer dosages has not changed. But life certainly is better than it has been in a long long time. My attitude is so improved its difficult to describe. I was worn out on the constant oily swollen mess. I am normal again, I had forgotten what that felt like. Damn this stuff works like a charm. Sure would be nice to keep my colon, hair, libido and sanity in the process... heh, heh. OldLawyer, I hope you will stay in the background and step up when the time comes with some info as to your outcome. I hope all this bantering and posting hasn't driven you away. Well, I am gonna go to bed and wake up oil free and clear all on 40mgs (soon to be 20mgs a week) a week. I am excited to try the even lower dose the Derm has planned next. I will keep posting, not sure who is reading this pedantic drivel but what the hell. 4000 plus views, someone is looking at it............... Good Night!!

Best Wishes
LowTane:wave:
19 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 7 days

Well, not much to say here. I am half way through the second month of my Accutane therapy. A total of 660mgs of Accutane have been consumed. As you know the title of this thread is "LowDose" Accutane. What is considered low dose? Anything less than the common standard of .5 to 1 milligram of Accutane for every Kilogram of body weight. You will find that researchers consider the total cummulative dose the key factor in remission rates. So, you would end up taking just as much Accutane as a high doser. It would just take a longer therapy to reach the total cummulative dose. So, whats the difference? Some Doctors believe that higher doses result in better and longer remission rates. There are many reports of successful remission at higher dosages. Recently reports on low dose studies have also shown good remission rates for low dosers. Some doctors in other countries are using low doses bi-weekly to sustain remission in some patients. These doctors have reported that monthly blood tests are not required at these low dosages. So, this is actually where I wish to end up if I don't get a remission. Start low, stay low and try to avoid any longterm side effects at all costs. Now it should be noted I have found no studies on longterm low dose Accutane therapies. Short term studies exist. Therein lies the problem. Long term lowdose could be as much a risk as short term high dose. All of these assertions should be taken with a grain of websalt. Ask lots of questions, get more than one doctor's opinion if possible. Try to ignore threads like this one and form your own opinions based on professional resources only. I paid to get the scientific journal access for Rosacea, Acne and the effects of low dose Accutane. I am convince it is right for me, with my obsessive mindset and all. How is it working so far? Wow! My life has improved immensely. But, inspite of it all. There are a multitude of people suing and winning over Accutane longterm side effects. It is easy to find what seems to be normal average everyday people reporting on different blogs horrific experiences with this drug. I can't ignore that entirely, I just can't. It is anecdotal and non-professional reporting to say the least. I still think there is some merit in paying heed to these stories. It is also fair to say that many high dosers report the return of there acne. Yet, it is also fair to say that many high dosers report long multi-year remissions with no long term side effects. It is also my speculation that successful Accutane users aren't as likely to report. They are to busy having fun. With 12,000,000 users world wide reported it seems that the percentage of bad experiences might be low. So, in the end, I know nothing other than what my own research has produced in the way of a perception of Accutane. I just know this, if engaging in certain behavior can result in a permanent long term outcome, I really want to dot my eyes and cross my tees before leaping into a therapy. My experience with doctors has shown me that it is okay to second guess them. This is where the "get a second opinion" cliche originated from. People second guessing their doctor. Please read up on possible longterm side effects. It is not a fantasy, many of these effects are listed right on the warning label in my very own Accutane prescription box. I am just a regular person trying to deal with a mentally devasting physical condition. Acutally two conditions. I have both Rosacea and Acne, and because of Accutane you would never know it. It has amazed me to no end......

I wish you the best...

LowTane
19 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 7 days

I am not sure who is following this diatribe, but it is getting a bit thin on content. I will start posting weekly. Its getting too repetitive, all I can say is every day I am still 100% clear. I think this will get interesting again when I have terminated my low dose therapy. I leave you with this summary:

I started taking what is considered low dose Accutane for my size. This was made possible after I lobbied my Dermatologist with no less than 5 different studies on low dose Accutane from several different countries. After I dropped off the material I got a call and he set the dosage along the lines of the average low dose reported in the aforementioned studies. The first month I took 20mgs daily. I had immediate results. I had been given an antibiotic that doesn't contraindicate with Accutane in case the intial breakout was bad. He didn't want to do this at first, but it turns out I didn't need it. Accutane went to work gangbusters. With this dosage I had only some mild side effects. Slightly dampened libido, dry lower lip and an occasional mild headache. After the first month I was 100% clear. I then dropped my dosage to 20mg every 4 days. I remained clear...I then dropped it to 20mg every 7 days. I am still remaining clear at this dosage. This is where I am now.
I will continue my low dose experiment. When I have something to report I will certainly post it. Until then, I can only say you might consider low dosage if you have moderate or maybe even severe acne. You might consider low dosage if you have major oil problems. Hell you might consider low dosage if you have a hang nail......I have to say it has been a miracle for me so far. I fear the high dosage idea and will probably never ever opt for it. Doesn't mean that high dosage hasn't worked for people. It has.. I just believe that it makes permanent side effects even more possible. These are my own personal feelings, like I said, a grain of salt. I know nothing about this drug in all reality. I am just operating on my personal instincts. So, my observations only serve one purpose. They are cathartic for me. It may however help someone to hear someone else's story. Please read read read and get lots of doctor's opinions before saturating your body with this controversial miracle drug called Accutane.

I wish everyone the best.
LowTane
24 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg every 2 days

Good to hear from you OL, glad all is well. I have nothing major to report, bumped my dosage back up to 20mg every two days instead of 7. This was based on reading the local dermatologists boards and gaining a consensus. Many believe the total cummulative dose is the ticket. Doesn't seem to matter how you get there, as long as you do. Mild side effects and still one hundred percent clear. Still having a small glass of Cab Sauv once in a while. Down in weight as well. Libido functional with slightly diminished drive. Well thats all folks..........

Best Wishes
LowTane
Shidoshi, I don't know if this will help...but my libido problems have vanished. I am back on 20mg daily as of this writing. I actually feel like my body has adjusted somehow to the Accutane. I don't know if this will remain this way or not. You may adjust after a time. But, didn't you take Accutane before? If so, what were your libido reactions then?
As far as I am concerned, my pores seemed to get stuck for awhile. I could see stuff inside them... I gently massaged and squeeze my nose and all these really hard little golden pebbles came out in mass. Looked like beach sand in the sink. I believe this to be dried out sebum. After I did this my pores looked horrible for a day. Then, amazingly enough my pores shrunk even smaller than previous results had shown. I actually think these hard granules were keeping my pores open. I am ecstatic.......!!!!!!!! I am oil free, not peeling at all. No real noticeable side effects. I am still in love with this drug. No longer as scared as I was when first taking it. I wish all readers the best of luck. I really like the lower dosage approach. My reading shows that many doctors are also migrating to the lower dosages. I may be on it longer, but thats okay. It is becoming transparent, like taking a vitamin or something. I still take it at night before bed.

Best Wishes
LowTane
Shidoshi, I slowed down to 20 mg a week for awhile. I felt better and my skin's progress didn't seem to change at all. I am now back to the 20mg daily. If I have headaches and libido problems I will probably back off again on the dosage. I believe that doing the least amount of harm while building on the total cumulative dose is the way to go. If I don't get a remission after all of this I may try another round. What the dosage will be I have no idea. I am hoping that life style changes coupled with the Accutane therapy will give me a new acne status quo. If I have a relapse I will go back on antibiotics until my rest period is up. I will then try Accutane again. The last possible idea is exteme low dose long term. I have thought about this quite a bit. Some doctors are doing this with some patients. It violates the FDA's rules for administering this drug. I guess they are williig to take this chance with their licenses. I am at a point now where I can't tell I am even taking this drug. The lack of oil and the smallest pores I have had in 12 years are what remind me that his drug is still present in my system.....

Best of Luck All
LowTane
Hello......

I have a Derm Appt. on thursday. I will be checking my cholesterol, triglycerides and liver enzymes. I expect if he remembers I will get my current 20mg dosage lowered. We shall see....... I will continue with this low dosage ideal until I reach some sort of an outcome. I don't think this board will be all that interesting until my therapy is complete. The days following successation of said therapy will be the most interesting. Will I get a remission? Or will it be a full blown oil slick and a regression into social leprosyship? Thats the most important question. I have no idea..... I wish I could post all the studies I have read so that you could read them in one place. I can't, almost everything is copyrighted. So, I can tell you about them, and hopefully you can find them for yourselves. Right now I am enjoying life more than I have for quite some time. This drug as far as I know is a miracle for me. It is the answer for my problems. How will I end up? I am not sure, low dose maintenance for the long term? Will I get the Derm's blessing for intermittant low dose? I don't know. My pores have shrunken in ways I couldn't have imagined. Blotchiness reduced to levels I never dreamt of.........I feel normal. I can touch my nose. I am out of pain. I look like a normal human again. I am in love with Accutane, and yes, still fearful of this drug. Well, that is it for tonight. Can you drink on Accutane, well this post was conceived on 3 glasses of a very good Cabernet Sauvignon.

Nite
LowTane
Hello All

Well I am back from the Derm. We will lower my dosage to 10mgs daily. All blood tests were baseline normal. I am not having major side effects at 20mg. It will be interesting to see if the lower dose will still maintain the status quo of the oil and acne manifestations. To any Rosaceans reading this, you should know that not only has the Rosacea subsided, I am able to eat and drink trigger foods with wild abandon. I have had no flushes and my face maintains an even tone and color with a mildly flushed appearance that resembles minimum time in the sun. I am going to experiment with low frequency red light to see if I can promote some collagen. It seems as if Accutane has stimulated something in the way of collagen on its own. Scars seem to fill in some, this, along with major pore closing. Its an amazing drug. If you have moderate acne and major oil you could consider trying to educate your Derm to the idea of off label low dose Accutane therapy. It will change your life. All the while keeping in mind that side effects have been reported at all dosing levels. I believe this drug can be extemely dangerous to different individuals at all dosage levels. I wish you all the best.

LowTane
In summary:

The purpose of this board was to explore the results of using low dose Accutane (Isotretinoin) over a longer period of time than normal therapies with high doses used in a shorter period of time. After becoming desparate with Sebaceous Hyperplasia (enlarged over active oil glands) and mild Rosacea I began reseaching the web heavily and discovered some studies in foreign countries that showed the efficacy of lower doses of Accutane. Why go with lower dosages? To minimize side effects, long term and short term. The end result desired? To go into long term remission for Acne and Sebaceous Hyperplasia. Here is where the debate begins. Some studies have shown significant remission rates with lower dosages. The United States is furthest behind in this type of therapy. Just talk to your Dermatologist and see..... The rule of thumb in this country is "higher dosages = longer remissions and/or possible cures". Individuals have reported the return of their acne with high and low dosages. Other individuals have reported cures and long term remissions with both high and low dosages. We have all heard time and time again that everybody is different. Even though we are of the same species. Its true, drugs seem to effect people differently. I am opting for the lowest dose possible and still maintain an acne oil and rosacea free face. So far I am running perfect, first on 20mg a day and now 10mg a day. I will try to lower the dosage again upon my next appointment. My American Derm is suprised and mildly shocked at the overwhelming positive effect low dosages are having on me. I am 200 pounds. I have referenced links to different studies on Accutane therapy at pubmed and medscape. Talk to your Derm and show them the studies if they are not already enlightend to low dose Isotretinoin therapies. Best of luck....

PS. No matter how I try to explain the positive effect this drug has had on my life it will be understated. I am ecstatic. I have regained my life for the first time in years. I say this knowing that the longterm problems some individuals talk about where this drug is concerned could still be waiting for me somewhere up around the bend.

LT

Disclaimer: Accutane can be a very dangerous drug for some people. I believe this with all my heart. I don't wish to talk anyone into using this drug. Do your homework, consult multiple doctors. And never, ever self medicate off the internet. To many items need monitoring with monthly blood tests to take a risk self medicating. Read about all the possible side effects this drug can cause. At any dose this drug causes birth defects. Remember, what works for one person may be a catastrophe for another.
Hello!

Here is a quick summary as to the intent and direction of this thread.

49 Year Old Male
2 months of 20mg Accutane daily, reduced to 10mg daily.
Total therapy is right at 4 months.
Symptoms: Acne Vulgaris, Sebaceous Hyperplasia (massive oil) and Rosacea.
Accutane put a halt to all symptoms within the first month.
No depression, (actually the opposite) I am euphoric about the results.
Sex drive, temporary setback but settled back to normal within a month and a half.
Side effects at this point as far as I can tell are Zero.

I have posted links to multiple studies in regard to Accutane dosages. My philosophy is not my own. I got the idea for low dose therapy from the aforementioned studies. The idea is to stay on it longer than short term high dosage conventional therapies advocate. The consensus amongst the studies are that total cummulative dose is the important factor not the duration or dosage level. Not all Derms agree on this point. I am trying to prove the theory for at least one human being. I love what this drug has done for my life. Words do not do justice to the effect this has had on my job, my marriage and my mental well being.

Disclaimer: This drug can be extremely counter productive to some individuals in my humble opinion. I am a complete layman with no formal training in area pharmacology. So its obvious my opinon means little. I can only report my results.

I have an appointment on the 7th, I will report anything new. I hope that some readers will find the same satisfaction with this treatment. Print the studies linked and show your Derm. Try low dose before high dose. Most doctors won't object to this before urging you to higher dosages. I refuse the high dose therapy, I will never concede to a higher dose regimen. Thats just me...........

Best Wishes
LowTane
Hi all....

I am back from the Dermatologist and the blood tests are the same as always. Cholesterol and Triglycerides are normal, for me anyway. We are going to take the dosage lower. I will now skip dose the 10mg's a day to 1 capsule every other day. We talked about long term outcomes and total cumulative dosages. I would have to be on Accutane for a long time at this dosage to hit the often mentioned "total cumulative dosage" of 120mg's per kilogram of body weight. At these dosages I can see he is considering a possible maintenance dosage. He mentioned he has a guy that has been on 40mg's once a week for 7 years. Which is equal to about 5.5mg's a day. Which is around 1/15th the normal dosage of 80mg's daily for a short term therapy. So it would take 15 times as long as the normal regimen of about 4 months. So that is about 60 months, or 5 years. What does it all mean? I am not sure. I think that the more I read I find some doctors are starting to see alternative therapies as a possible course of action with Accutane. When you think about it, its possible that some individuals could get maintenance dosage levels long enough for their body to actually change on its own to an acne free state. Who knows? I can tell you this, the low dosage wouldn't even be noticeable if it weren't for the lack of zits, oil and rosacea. I am much happier at this lower dosage than I was on the 20mg's. Even though the 20mg's wasn't that bad. Still, I had some weird feelings and libido problems on 20mg's that I wasn't sure that Accutane had caused. However, on 10mg's those symptoms are gone.

Well thats about all folks, it's life changing. It's controversial and maybe even dangerous. I believe that low dosage this drug may help some people but not others. I believe some people could have problems with this drug at any dosage. I will continue to share what I can as it comes up. Read all of the studies from the links provided in multiple posts. When you goto pubmed and medscape, help me and others out here. Re-post those studies. Make sure you only post health board approved site links. Pubmed and Medscape are government run and I was told okay to link to.....

Best Wishes
LowTane
Hello all

Derm appoint today. She is keeping me on 80 mg every other day and 40 mg on the other days. Since the increase last month, triglycerides are slightly higher, but minimal. She said that keeps everyone on for 20 weeks and then evaluates. Extreme cases could go a year. She did caution that after I stop, oil production resumes to some extent. If it does so, without breakouts, I can live with that. My daughter claims that her skin is slightly oily after about 8 months off, but she does not break out. We also spoke of dosages. She said that she never breaks out the calculator, but that the main thing is cumualtive dosage in a given time frame. She also said that her minimum dose is .5mg per kilo of body weight per day, and her max is 2 mg. That applies only to the 20 weeks. Right now I average .7mg per kilo of body weight by my calculations, so that is on the low side for her. At this pace, after 20 weeks, I will have ingested 7800mg, or about 92.75mg per kg of body weight total. She indicated that after 20 weeks she may wean me off at 20mg per day, and may keep me on 40 mg PER WEEK for a while, to get up to cumulative dosage. She also said that sun exposure and sensitivity differ for everyone. Other than some dry skin and chapped lips, I have no side effects. My skin is clear, but sensitive....meaning if I try to force anything out, it leaves a red mark for a few days. Otherwise, all is good.

LowTane...curious to see if you have any studies on resumption of oil production.

I hope all is well.
Hello all....

Just thought I would check in.... Not sure who is viewing if anyone. A quick update:

200lb
49 year old male
Sebaceous Hyperplasia
Rosacea
Acne Vulgaris
Started on 20mg Accutane daily for two months or so..
Switched to 20mg every other day for a month
Currently 10mg every other day...


All symptoms are gone!

This board has reached a statuse quo. There are no new items to report as of now other than this fact. The 10mg a day therapy seems to allow me to have normal sun exposure. I was out doing yard work on a cloudless day for 5 hours. No problems. So..continue to check back to see when the Accutane therapy ends. It will then be important to post what happens post therapy. Make sure you go back into the posts and use the Medscape and Pubmed link info to read up on different Accutane therapies taking place in different countries. This information may help sway your dermatologist into trying low dosage therapies before higher dosage therapies are employed.

Best Wishes
LowTane
Good to hear from ya OL!


Summarization:

This thread started with two main characters. Lowtane (myself) and Old Lawyer. Lowtane started on 20mg daily of Accutane while OL went with a more traditional dosage of 40mgs daily. LowTane continued to lower his dose slowly overtime while Old Lawyer had his raised over time. Two different therapies for some of the same type conditions. In effect Sebaceous Hyperplasia (massive oil) and resulting acne. LowTane had the lovely addition of Papular Rosacea. So far both candidates have had a complete remission of all symptoms from their ailments. The thread was fairly exciting at first with the onset of results. Once the Acne, Rosacea and oil disappeared the thread became a little dull with nothing new to report. So, I posted multiple links throughout the thread pointing to studies from two board accepted sites. Pubmed and Medscape. The studies are wide ranging geographically and ideologically. Many countries have been more pioneering in the approach to their usage of this horribly controversial drug. I used these studies to convince my Dermatologist to try a low dosage regimen. He bought in and here I am. With my dosage sinking ever lower the drug remains effective and I have zero side effects. I will however be on this drug longer than Old Lawyer. The one main idea of Isotretinoin therapy revolves around total cummulative dosage. This is the total ingested milligrams per kilogram of body weight. Because of this I will be on the drug longer than Old Lawyer. The total most agreed upon in the medical community seems to be around 120mg per Kilogram of body weight. Convert your body weight to kilograms and multiply it by 120mg and you will get the correct total. What everyone should know at this point is this: I believe this drug has caused some individuals severe health problems. Even after they have stopped taking it. I also believe some people have taken it with no problems at all. Millions have taken this drug. There are not millions of lawsuits. Accutane is extemely effective period. At what cost to each individual is the subject of much debate. I am a chicken, I have opted for low dose simply from fear. Also, if I were you I would not self medicate. You must have the blood tests to keep an eye on this drugs affect upon your cholesterol, triglycerides and liver enzymes. You are risking a heart attack or destroyed liver without knowing the facts only a regular blood test can provide. My life has been changed for the better. At what long term cost if any is unknown at this time. I believe old lawyer and I will make this thread interesting again when we cease our therapies. I don't want to tell a single person to take this possibly insidious drug, yet I want to kiss a chemist every time I meet one. What incredible results! My life has been changed. Just remember, what works for one person can be a devastating failure for another. I would suggest the low dose approach initially just to see if your body can deal. Some doctors online report using the low dose approach before going to higher dosages. I love the low dose approach. Even if I had to stay on this drug for life, I wouldn't mind if the dosage was only 10mgs once a week. I am now doing 10mg every 3 to 4 days. At this dosage I am not even sun sensitive. Rosacea is zero, oil is gone. No zits....yeeehawwwww!

Best wishes
LowTane
Hello All

Interesting derm visit today. To recap, last month I had half a beer 14 hours before a blood test and my liver enzymes shot up to 90. My dosage was reduced to 40mg a day (was taking 80mg every other day and 40mg on the other days). I was told to wait 2 weeks with no alcohol and take another blood test, then wait 2 weeks again and go for another blood test. After the first test, and about a week before the second, I had 3 drinks one evening. I am happy to report that all levels were normal....back to preaccutane standards. The derm is keeping me on 40mg per day for another 30 days. I am 185lbs. After this month, I will have 8400mg in 6 months, total. She said then I am basically done, except that I will have 30 pills extra, which will be taken over some extended period of time. I asked her about the return of oil and she was a bit evasive. I pushed her and she said I can expect some return, especially because I was so oily before. She said there are things she can do about it. After some prodding, she advised that a low dosage of 10mg to 20mg a week may be used for maintenance purposes, depending on what happens.

Now, I did notice in the last week that my 4 most stubborn pores (historically where I aslo seemed to be broken out all of teh time) became inflamed slightly after sun exposure, for the first time since I have been on this drug. The spots were minor, but itched and peeled a little. The derm said that it looks like the sun caused it and she will monitor them and consider freezing them to protect against skin cancer. She gave me some Locoid, a 1%cortisone buytrate cream to apply.

Other than that, I feel great and I look so much better. One more month and I am done with the heavy lifting. After that, we shall see....

Regards.
Old Lawyer, very interesting indeed. I am sure we will all be interested to have you post regularly if you will after you have completed your therapy. I know I am....... I am really interested in your Derms comments on maintenance dosage levels. My Doc just suggested that was all we were doing with my therapy. He doesn't seem to think there will be any remission. I will stop this drug some day and I will still get to see if the low dosage regimen had any remission outcomes. Just to remind readers, I have been on 20mg daily and tapered to 10mg 1 day on and two days off. I have no acne or rosacea symptoms period. I do have oil and you can blot it, but it is minimal.... I will also report my results post accutane whenever that happens. I really think there is a place for low dosage maintenance for oily people.

Best

LT
LowTane:

If its possible, could you write out your dosage from day 1 to now. Something like:

Day 1 to 60: 20mg every day
Day 61 to 90: 20mg every other day
Day 91 to 120: 20mg every 4 days.
[QUOTE=LowTane;4039621]Exxon! No I did not know that!! Wow, I will do some research......

Stophy you almost hit my regimen with your numbers:

Day 1 to 60: 20mg every day
Day 61 to 90: 20mg every other day
Day 91 to 120: 20mg every 4 days
121 to 150: 10mg daily
150 to 180: 10mg 1 day on 2 days off

This is very close.

LT[/QUOTE]

Thank you so much, I don't understand why you went from 20mg every 4 days, then 10mg daily. It seemed like a huge bump on your dosage. Averaging 5mg/day(day 91 to 120) to 10mg/day(day 121 to 150) :dizzy:
Also,

The biggest side effect I'm facing, is the big red clown lips At 20mg/day. It seems like I should join the circus. Whats the highest dose you took, that didn't affect your lips at all. I want to recommend to my derma to make my dosage even more smaller, even If I take a longer course (I dont really mind)
The highest dosage of Accutane I have ever taken was 20mg daily for 2 months. I switched to 10mg daily for a couple of months after that...... I had zero side effects that I could detect.....


LT
Hello!

Summary: Low Dose Accutane for Acne Vulgaris and Rosacea

I am a 49 year old 200lb male and I have been on what is considered (for my body weight anyway) low dose Accutane since February of 2009. I have dual maladies, I am blessed with Rosacea and Acne Vulgaris. Due to the nature of my job I am constantly under fluorescent lights and speaking in front of groups of people. Both Rosacea and Acne look even more hideous under these type of lights. My appearance was affecting my job in a most profound negative manner. I had been aware of Accutane for 20 years, or since its inception into the Acne family of drugs worldwide. I always feared Accutane from day one. One day in desperation I once again began researching this controversial drug and found a study done in Israel on low dose therapy. Hmmmmm!!! I said. I decided I had to try this approach.

I began this treatement in Feb 2009. 20mg daily was prescribed only after convincing my Dermatologist with a barrage of worldwide studies in the efficacy of low dose therapies for certain Acne and Rosacea conditions. Please consult Pubmed and Medscape for all the ammunition you will need to create a portfolio for your Dermatologist. Be prepared for apathy from your Derm over internet research. Make sure you let them know that you have legitimate studies from government reporting sites done by actual researchers. The USA is woefully behind in the low dose approach with this drug. So much so that it is considered off label treatment when other than the prescribed high dose regimens are applied. Have sympathy for your Doc, they want to keep their licenses.

Anyways, I started on a higher dose than I wanted to because my Derm was a little skeptical. I gradually reduced that dosage over time and began to just tell him how much I was taking and he would look at the results and tell me to stay at that dosage for X amount of days. I would ignore him and lower the dosage again. Next appointment same routine. I am now trying just 10mg every saturday. I will let you know how that works for me.

My treatment thus far has been one hundred percent amazing. My life is so much better that I cannot express it in words. My oil is controlled and my pores have close up. Some pores were so damaged from years of popping and picking that they didn't close all the way. So I still have a few big pores in a several areas. I could probably finish the job with some laser type therapies that my Derm and I have discussed once I get off the drug.

So in short low dose Accutane has worked wonders for me. I have Zero side effects that I can detect. It has been like taking a vitamin pill. It is a shame we are in danger of losing this drug. In light of recent events and lawsuits drug makers are re-thinking their bottom lines. Roche has quit selling it, and a few drug makers say they will continue. So for now it appears we can still get Accutane. It is a shame that low dose therapies were never really explored in the good ole USA.

In closing: This drug, like all drugs has side effects. Different people respond differently. If you have excess oil, mild Acne or Rosacea or both, think about low dose. It might be your ticket. However, there is always a risk with any drug.

Best Wishes
LowTane ;)
Hello Lowtane! First off all congratulations for creating this very interesting topic. I'm not going to bother you with details of my acne/oiliness story, just saying that after realizing that accutane is the only thing that works for me, and every time I am off my acne returns (I did 2 full 6 months courses in the past) im considering a similiar regime from now on. Im planning on taking 10mg daily until I get clear and then im not sure how Im going to be taking accutane. Let me explain:

Do you now whats the difference of taking for example. two 20mg pills each week or taking 4 10mg pills also for each week (the cumullative dosage is the same), or even taking 10mg daily for 10 days and then 20 days off and then again 10mg for 10 days and so on(this would be almost the same as taking 10 mg 3 times a week. Well i think you get my point. Im confused on what is a better aproach. Ive seen various studies when they talk about this but i cant figure out whats the difference. =/ sorry for any english mistakes and good luck with the resto of your regime!
Well hello everybody, or anybody who happens to come by. It all started Feb 2009. I got tired of antibiotics and went complaining to a dermatologist. I expressed my desire for a low dose alternative to the usual high dose therapies employed typically in the United States for a drug called Accutane (Isotretinoin). I started on 20mg daily for a couple of months and then started tapering the dosage down over the next 4 months. I have mild Rosacea and Sebaceous Hyperplasia (tons of oil basically) and have no signs or symptoms as of this writing. I just quit Accutane, I will be getting some laser treatmens next week and I had to be off the Tane. I have been quit for about one month. It will now be interesting to see what happens. I have an open invitation to come back to my Derm and start low dose again. So..... the clock is ticking. I will let you know when the Sh#$ hits the fan..
49 year old male.
Rough estimates of dosages follow:
Started 20mg daily Accutane (Isotretinoin) Feb of 2009
Reduced to 20mg every other day after 2 months
Reduced to 10mg daily for one month
Reduced to 10mg every 3 days for one month
Reduced to 10mg once a week for 2 months
Quit Accutane

I have (had) Rosacea that flared with pustules along with Acne Vulgaris on the nose and chin. Sebaceous Hyperplasia (max oil) afflicted me as well. I researched low dose Accutane and found multiple studies in other countries where outcomes were extemely positive. I found these studies on legitimate sites that report research outcomes. Pubmed and Medscape mainly. I took the studies to my Dermatologist and showed him the results. He tried it with me and I have had great results. Its true that the low dose approach may not work for everyone. Its also true that the high dose approach may not work for everyone. Ingesting a drug until your nose bleeds and your eyes dry out doesn't appeal to me, it never did. I wouldn't commit to high dose therapies. It was never an option.... It should be noted that millions have tried the high dose therapy and have had success. In light of the bad press Accutane has had, a low dose movement would be welcome. When you approach your Derm don't mention blogs. Ask him or her about research papers that you found on Pubmed and Medscape published from Dermatologists in other countries. See if you can get them interested or at least talking about it. You can always go high dose later if low dose doesn't cut it. Accutane changed my life for the better, no doubt. I have had success so far and zero side effects. I didn't even have dry lips. My pores have closed up, my oil had dropped to normal levels. My Rosacea has abated. My dosage was extemely minimal. I pray they don't pull this drug from the market. It has saved my life, my career and restored my self image. I may need it again, its to early to tell. I have been off of it for a couple of months now. I am getting laser treatments for pores and veins in my nose. I will continue to report the post Accutane results until it doesn't matter anymore. Please read this entire blog for more hints and tips to my approach. The fact is, very low dose therapy worked great for me so far, and no side effects. Less risk. Dermatologist will tell you that the exact mechanism that causes Accutane to work is unknown. Understand that Doctors are going off label and risking licenses even though they are giving less of a drug. Seems strange, but its true. The FDA has stringent guidelines for this paticular drug. Know for a fact that this drug can cause severe birth defects at any dose. Know also that some people suffer horribly from the use of this drug even years after ceasing usage. Although this hasn't been conclusively proven some court cases have been won. These patients swear this drug caused their problems. I believe it to be possible. I also have an opinion that high dose is what caused these individuals to have long term problems. However, millions have taken this drug high dose with no problems reported. Drugs affect different people differently. My results may not be your results. Never self medicate with illegal drugs from the internet. You must have blood work when using this drug, you could die. See your doctor and ask for a low dose approach. See what happens.


I wish you the best.
Well you sure don't post as much when your acne is at bay..... I am off Accutane for around 4 months. My oil has increased slightly with only an occasional pimple. Pores are about the same. All is still well. I am still waiting for the other shoe to drop. To new readers of this blog.... I am a 50 year old male about 200 pounds. I tapered from 20mg daily to around a 10mg once a week accutane dosage over a period of 6 months. It has put my acne vulgaris and my rosacea in remission. I don't get the red flashes and pustules or zits any more. I had tried everything over the last 35 years. I believe in the low dose regimen. I had virtually no side effects at these dosage levels. I have recommended repeatedly on this blog that individuals go to pubmed and medscape and create a portfolio of low dose studies to present to their dermatologist. They may or may not listen. I am no expert of any type, but I have the opinion that dosing at levels that make your nose bleed and your lips crack off your face may affect other body parts in an adverse manner. I just couldn't get myself to agree to those levels of this controversial drug. The argument is will lower dosages give long term results? Well, I am testing that theory on at least one person. Accutane improved my life one million percent. Dried up my oil, closed up my pores, cleared my Acne and killed my Rosacea. The extreme social unease that I have been living with is gone. Remember to strategize when approaching the doctors with the low dose idea. It is not prevalent in the USA, be sure to tell them that PubMed is a service of the US National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals and that medscape is a physicians resource site. Do not tell them stories from blogs with personal accounts like this one. They consider the information anecdotal and unsubtantiated. I agree with them on this point.

Good Luck

LowTane
Heading for 8 months off of Low Dose Accutane!

Treatment Duration: 6 Months

Dosage: Started at 20mg daily, tapered over 6 months to 10mg once a week.

Age: 50

Weight: 200

Sex: Male

Side effects: Extremely minimal, light drying of the lips.

Results: Cured my Acne Vulgaris, shrunk my pores by 90%, put my Rosacea in permanent remission, adjusted my attitude from deeply depressive solitary behavior to upbeat outgoing positive socialite.

Strategy: Use legitimate studies on low dosage Accutane published on pubmed and medscape to convince my Dermatologist to give it a try.

Comments: My philosophy is that drugs are bad in the first place. I will never submit to the high dosages of this drug administered in the USA. Other countries are embracing low dose treatments and getting great results. With the low dosage approach my fear was minimized. I feel I could do it again if need be......Anyone going through what I did with Rosacea, Acne Vulgaris and Sebaceous Hyperplasia (massive oil) gets my total sympathy. I don't know if my approach will work for you. It just makes sense to try this drug in a very low dose to see if you can tolerate it. You can always try a higher dosage later on. Do you homework and copy legitimate studies and take them to your Derm. Don't take in stories and blogs, they will not listen to anecdotal data. Ask them if they know of Pubmed and Medscape reporting agencies. Be organized, be firm. There are multiple countries who have published studies on the efficacy of low dose Isotretinoin (Accutane). I wish you the best.

LT





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