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11 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
New behavior:None today

Day 6:
Well, I will be taking my 6th pill in a few minutes. I gotta tell ya, you probably won't believe me though. My pores which I double checked with my Wife are reduced by over 50 percent. I was blotting 10 times a day with tissues to soak up oil. I now blot 4 to 5 times a day during work. My acne was under control from a year on Doxycycline, so I didn't have much when I started Accutane. However, by now I should be breaking out gang busters with Acne Vulgaris all over my nose. Ususally my nose is throbbing from the swollen sebaceous glands. It is feeling of normal size again. It actually looks smaller. It is like a switch has been thrown and my oil glands are being told to stop. My pores are shrinking at a rapid rate. A 100mg dose (20mg once a day) of this drug has caused these reactions in only 5 days. I say it again, I am very scared of a drug that has this powerful effect in that period of time. To the rosaceans who may be vieiwing this log, I feel extreme hot flushes in the cheek but not my nose, however when I check to see how bad it is, it is insignificant. I look mildly flushed compared to how I used to look. My side effects are extremely mild to none. Slightly dry upper lip is all I have..... I have read many horror stories about this drug, I won't go into the details. So, my fear levels are high. I am happy and at the same time scared to death. I really want to take even lower doses. I have considered getting gelatin caps and a syringe and drawing out 5mg doses to put in the caps. I wished this came in pill form so I could break them into pieces. I am not sure what I am going to do yet. It almost feels as if my body needed this, it makes me wonder how it works. Its like something out of whack has been corrected. Some individuals lives are ruined by this drug. I find that it is the high dosers who report the worst problems. Low dose this drug might just be heaven sent. My job is already one hundred percent better. My wife is throwing a party this weekend and I am actually looking forward to it. Miracle or curse......we shall see.:confused:

Declarative statement: I am not recommending this drug. I am only reporting results in the most objective manner I can muster. I do believe this drug can be dangerous. I am taking this risk of my own accord. Please read other blogs that discuss the seriousness of possible long term side effects.

Best Wishes
LowTane
OldLawyer absolutely do not stay in the background. Look how many viewers this thread has had already. Post your results so individuals who may take this option can compare more than one story. Any other individuals currently on Accutane please post as well. If you would, please list age, dosage, gender etc...

19 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip

Day:15
Well, I am starting to sound like a broken record probably. I blotted my normally horribly oily skin one time today. Unbelievable, normally I blot 8 to 10 times a day at work. This alone is cause for celebration, I am loving this drug so far. I am on very low dosage and obtaining these results. Still no side effects other than dry lower lip. I will continue to test the sex drive on a regular basis, (somebodys gotta do it) it is in the interest of science you know.;) Well pill 15 soon......


Best Wishes
LowTane
22 Feb 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily
Symptom: Dry lower lip & Minor skin flaking on the nose.


Day 17: Well this report will be a summary of events upto this time. I have experienced no significant side effects from this low dosage of Accutane. I am taking the Sotret brand. My lower lip is just barely dry. Every now and then I have a little piece of skin on my lip get dry enough to peel off with my teeth. This is rare, now this is significant. If you haven't seen what "high dosers" go through you need to go surf and read. Then again, I may not get the successful remission that high dosers may get. Now for the good part. My life has been so positively affected that I am shocked. My attitude, my willingness to participate in life. My students have noticed the difference, I am having fun teaching again. My personal space when talking to people has gotten to a normal distance again. I am not blotting during the day more than once or twice. I can touch my nose and my fingers don't feel greasy. My zits are coming and going at a rapid rate. My red blotchy appearance is showing a more even normal colored skin tone. Pores I thought were going to take plastic surgery have shrunk by 65%. My nose dosen't feel swollen anymore. My rosacea symptoms are non-existent. Veins in my nose have dissappeared. What can I say, I am hooked on Acctuane. My quality of life has already improved by 80% in just a little over two weeks on this miraculous drug. I can't tell you how this makes me feel, what an amazing experience it has been already. So, there.... thats how I feel today. I wished to God I had tried this drug a lot earlier, before I had so much scarring. Oh well... maybe laser will finish this journey off it I get a good remission. Well, folks...I recommend a low dose experience, even lower than mine. Possibly microdose will be the way of the future. 2.5 milligrams total daily. Like a supplement, who knows. Well, pill #17 is on deck. I will take it with milk to increase the absorbtion. It is fat soluable..............:p


Best Wishes
LowTane
Just wanted to put my two cents in. I used Accutane 3 times! The first two times, a very low dose..the third time, much higher. Almost a year in between each of my rounds, and each and every time by the time the year ended, my skin was twice as bad as I started! It seems for me, that as soon as the oil glands start to "repair" themsevles- my acne, which is mostly cystic- comes back tenfold.
My derm suggested I try Photodynamic Therapy ALA , which is a more permanent solution. I had my first treatment on Friday...it was slightly painful, but by the time it was over, it wasnt so bad...the next day, I was red and flushed, like a sunburn, however no pain at all. Ive been moisturizing like crazy! What I do notice is that there isnt a blackhead or whitehead on my face- the two cysts which were starting to form went down significantly and the few actual pimples which were there dried up over night and are virtually gone. The scarring, which is what Im most concerned about - has not changed at this point, but my derm did say it takes up to a week or two to see any results and which probably take 3 treatments spaced 2 weeks apart to show significant differnce.
Im stoked to see if this works. There are NO physiological side effects to this procedure...
best of luck to everyone-
nikki
OldLawyer, I know how you feel. My life and my attitude have just gotten better because of this highly controversial drug. I am glad for you to be able to go out and have the nagging nusiance of Acne off your back. Right on! Good for you.....

5 Mar 2009
Brand:Sotret
Weight:90Kg = 200lbs
Sex:Male
Age:48
Dosage:20mg once daily


Day 28 or somwhere close:

I went to the Derm and he was happy with the results. He has been working with Accutane with great results for years. He told me its possible to get a complete cure from this therapy. He doesn't however have high hopes that I will get one. He said most people get remissions, but not complete cures. At least in his experience. Now all this guy does at this clinic is Accutane. Thats his primary job description. So, he is the Accutane Doc at this clinic. He shocked me by saying he would like to take the dose lower after this next month of 20mg daily. I thought he would want to go higher. He wants to see how low we can go and still get the job done. He mentioned that most people end up doing Accutane more than once. I got the feeling he thought that if you have to do Accutane more than once it would be better if it were on lower doses. I agreed! In the old days some people were put on insane dosages of 80 to 100 miiligrams daily (and still are) with the idea that higher dosages gave a better shot at a cure. Studies in multiple countries have shown that low, medium and high dosages have resulted in longterm remissions. It affects different people in different ways. My Derm mentioned that he currently had one guy on one pill a week. He didn't say how much. If he goes off that pill he immediately reverts to his pre-acne state. So, to make a long story short, this blog may truly turn into an ultra-low dose blog after next month. I got the feeling we will stop this drug for sure. If I revert to my old state I will need to go back on Antibiotics. After a period of time of an un-specified length my Doc would let me go back on the tane...... So for now I am enjoying the lack of oil and zits. Now mind you I still have scars and some holes in my nose from prior bouts with Acne. But man, do I look a lot better. I just look kinda rugged and tough, yeah, yeah thats it rugged and tough. Well somehow I got a hot wife, so I guess I can survive the look. Well thats all for now folks, pill 28 is on deck in about 6 hours. Stay strong all. Just know this, Accutane works. Low dose might be all you need.

Best Wishes
LowTane
Shidoshi, I don't know if this will help...but my libido problems have vanished. I am back on 20mg daily as of this writing. I actually feel like my body has adjusted somehow to the Accutane. I don't know if this will remain this way or not. You may adjust after a time. But, didn't you take Accutane before? If so, what were your libido reactions then?
As far as I am concerned, my pores seemed to get stuck for awhile. I could see stuff inside them... I gently massaged and squeeze my nose and all these really hard little golden pebbles came out in mass. Looked like beach sand in the sink. I believe this to be dried out sebum. After I did this my pores looked horrible for a day. Then, amazingly enough my pores shrunk even smaller than previous results had shown. I actually think these hard granules were keeping my pores open. I am ecstatic.......!!!!!!!! I am oil free, not peeling at all. No real noticeable side effects. I am still in love with this drug. No longer as scared as I was when first taking it. I wish all readers the best of luck. I really like the lower dosage approach. My reading shows that many doctors are also migrating to the lower dosages. I may be on it longer, but thats okay. It is becoming transparent, like taking a vitamin or something. I still take it at night before bed.

Best Wishes
LowTane
In summary:

The purpose of this board was to explore the results of using low dose Accutane (Isotretinoin) over a longer period of time than normal therapies with high doses used in a shorter period of time. After becoming desparate with Sebaceous Hyperplasia (enlarged over active oil glands) and mild Rosacea I began reseaching the web heavily and discovered some studies in foreign countries that showed the efficacy of lower doses of Accutane. Why go with lower dosages? To minimize side effects, long term and short term. The end result desired? To go into long term remission for Acne and Sebaceous Hyperplasia. Here is where the debate begins. Some studies have shown significant remission rates with lower dosages. The United States is furthest behind in this type of therapy. Just talk to your Dermatologist and see..... The rule of thumb in this country is "higher dosages = longer remissions and/or possible cures". Individuals have reported the return of their acne with high and low dosages. Other individuals have reported cures and long term remissions with both high and low dosages. We have all heard time and time again that everybody is different. Even though we are of the same species. Its true, drugs seem to effect people differently. I am opting for the lowest dose possible and still maintain an acne oil and rosacea free face. So far I am running perfect, first on 20mg a day and now 10mg a day. I will try to lower the dosage again upon my next appointment. My American Derm is suprised and mildly shocked at the overwhelming positive effect low dosages are having on me. I am 200 pounds. I have referenced links to different studies on Accutane therapy at pubmed and medscape. Talk to your Derm and show them the studies if they are not already enlightend to low dose Isotretinoin therapies. Best of luck....

PS. No matter how I try to explain the positive effect this drug has had on my life it will be understated. I am ecstatic. I have regained my life for the first time in years. I say this knowing that the longterm problems some individuals talk about where this drug is concerned could still be waiting for me somewhere up around the bend.

LT

Disclaimer: Accutane can be a very dangerous drug for some people. I believe this with all my heart. I don't wish to talk anyone into using this drug. Do your homework, consult multiple doctors. And never, ever self medicate off the internet. To many items need monitoring with monthly blood tests to take a risk self medicating. Read about all the possible side effects this drug can cause. At any dose this drug causes birth defects. Remember, what works for one person may be a catastrophe for another.
Hello All

As a "high doser" I wanted to add a different perspective. I had the dosage increased last week from 40mg per day to 40mg every other day and 80mg on the other days, after 2 months of treatment. I have noticed no change and no side effects. The only real difference for me over the last 7 weeks is that I am not very hungry during the day and tend to eat more than before at night. Since I added the pills every other day, I now take one every morning and the second one at night on the required days. Before, I took them at night. I make sure I eat enough fat in the morning for max absorpsion. I acknowledge that everyone responds differntly, but for me this "normal" dose has been just fine. I assume I will be up to 80mg per day after my next visit in 3 weeks, but we shall see. I no longer consume alcohol regularly. I have imbibed twice in 7 weeks, and not to excess. I drink plenty of water. I am in a better mood most of the time, due to my improved appearance. Nonetheless, I really want the next 13 weeks to come and go so I can be done and see what happens. I remain skeptical about long term remission. I will keep you posted and wish all the low dosers the best of luck. I guess my philosophy is that if this drug is really pounding my body and my body wins, I can start the healing. My concern with low dose is that even though the pounding is less, it lasts longer. To me, it would be like getting nicked and cut until you bleed to death. So, if my body is going through the equivalent of a 5 month hangover, when the toxins are gone I will start to heal. On the otherhand, drinking every day for a few years and stopping just short of getting a hangover keeps your body from healing for a long time. Just my thoughts....
Hey thanks OL. I wish you the best on the higer dosage. I have definitely read criteria where successful remissions have occurred at many different dosage levels. I have no idea which is best. I just seem to find that side effects are worse at higher dosages. All things can reach a toxic level in different individuals. Lower dosages just seem safer is all. Many studies confirm now that the total cummulative dose seems to be the important factor, not time...... So, either way, I think this drug can provide some long remissions at low or high dosages. I am skeptical like you of the possibility of a cure or really long remission. That is why extreme low dose intrigues me. What if I have to be on it many times in my life. Its nice to know that extremely low doses are keeping me 100 percent clear. I am hoping that 1mg a day will keep me clear. I don't know that yet. But, if I have to take this drug long term to stay clear, I want the dose to be really low. I am leaning towards the idea that this may be how I end up.

I wish everyone the best, regardless of the chosen Accutane therapy. What an amazing drug, regardless of controversy. I am blown away at the results.


Best

LT
Hi all....

I am back from the Dermatologist and the blood tests are the same as always. Cholesterol and Triglycerides are normal, for me anyway. We are going to take the dosage lower. I will now skip dose the 10mg's a day to 1 capsule every other day. We talked about long term outcomes and total cumulative dosages. I would have to be on Accutane for a long time at this dosage to hit the often mentioned "total cumulative dosage" of 120mg's per kilogram of body weight. At these dosages I can see he is considering a possible maintenance dosage. He mentioned he has a guy that has been on 40mg's once a week for 7 years. Which is equal to about 5.5mg's a day. Which is around 1/15th the normal dosage of 80mg's daily for a short term therapy. So it would take 15 times as long as the normal regimen of about 4 months. So that is about 60 months, or 5 years. What does it all mean? I am not sure. I think that the more I read I find some doctors are starting to see alternative therapies as a possible course of action with Accutane. When you think about it, its possible that some individuals could get maintenance dosage levels long enough for their body to actually change on its own to an acne free state. Who knows? I can tell you this, the low dosage wouldn't even be noticeable if it weren't for the lack of zits, oil and rosacea. I am much happier at this lower dosage than I was on the 20mg's. Even though the 20mg's wasn't that bad. Still, I had some weird feelings and libido problems on 20mg's that I wasn't sure that Accutane had caused. However, on 10mg's those symptoms are gone.

Well thats about all folks, it's life changing. It's controversial and maybe even dangerous. I believe that low dosage this drug may help some people but not others. I believe some people could have problems with this drug at any dosage. I will continue to share what I can as it comes up. Read all of the studies from the links provided in multiple posts. When you goto pubmed and medscape, help me and others out here. Re-post those studies. Make sure you only post health board approved site links. Pubmed and Medscape are government run and I was told okay to link to.....

Best Wishes
LowTane
[QUOTE=kahkit;4104760]i'm 57kg, taking 40mg of accutane per day, however, instead of getting better, my face seems bloated and pimples grew even more.. my skin doctor assured me that it is normal, but after taking accutane for more than 3 months, my face seems worsen and pimples grow all over my face..

could anyone give me advice and tell me what to do?? is it suppose to worsen till swollen?? i'm really at lost and frustrated.. i look like a human wit elephant head now.. T.T pls help...[/QUOTE]

Well, everyone reacts differently to this drug. It almost always seems to take time for it to act. I have read and heard 3 to 6 months many times in many blogs. Do try to drink lots of water and eat very healthy meals. Hang in there.... I wish you the best.


LT





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