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I've also had experience om both. I was first on differin and it make me break out bad. AGH! hehehe I actually like the profuct though. Now i'm on retin-A which is a much longer process in healing. I've been on Retin-A for abut 16 months and have seen pretty good improvements, but tha thing i'm most surprised, is that Retin-A helps VERY well to reduce scarring. I had big cystic acne and thought for sure i was going to scar with big pits. But i've been taking Retin-A and don't see too many scars, and if i do, they're really small =) Retin-A does help with wrinkles which is another good thing. But i'm young and don't think it's going to help me out now. One word of advice to you too ... if you find a product that works, STICK TO IT !!! Everyones body is different and that's why some drugs don't work on them. So if Differin works on you, then by all means ... use it. Hope this helps. Take Care

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