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I have been using spiro for 10 weeks now and it seems to be working. I am taking 100 mg per day along with 100 mg of minocycline and a birth control pill called Desogen. at weeks 3 to 4 I noticed reduced major oil production on my face, but I was still taking a bc pill that was bad (Nordette) and kept causing breakouts. I started Desogen at week 5 or 6 and I stopped getting big pimples right away. I was still getting the little tiny bumps that sit under the skin, but those are tolerable. At week 7 I was doing really well and healing from all old breakouts (no new pimples), then I tried Retin A for the under skin bumps and it ate my skin off. So, I had to heal for a week or two and now at week 10 I have been pimple free for a little more than a week.
The side effects I've had were extreme fatigue during the first few weeks, and increased urination since it is a diuretic. Now I barely notice any side effects, but I am still a bit more tired than usual, but it is very tolerable.
I haven't noticed any effects from the potassium issue. Maybe a muscle cramp once, but that may not even have been caused by the spiro. So far I am pleased with the results.
Good luck and let us know what you decide to do!

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