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Is the erythromycin in a gel base or a liquid? Gels will dry your skin out, so be sure to put plenty of moisturizers on.

The erythromycin, you probably only need until the initial breakout period is over. However, with retin-A, you will need to keep on using it forever... if its teenage acne, until you 'grow out of it', if its adult acne, more like indefinately.

However, once you used it for a while, and it seems your acne isnt coming back, you can cut down the use to eventually twice a week. (just for maintenance)

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