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Hi, everyone. I'm new to the board and am in search of some answers about the comparison between Wellbutrin XL and SR.

My boyfriend has been on Ritalin + 300mg Wellbutrin XL for about a month now due to moderate adult ADD, and this combination's done wonders for him. He's taking the XL at about 11pm, and this gets him awake and ready to go to work quickly in the morning. Work puts significant demands for concentration on him - and this is just fine until about 5pm, when he's found that the XL wears off and his ability to focus is pretty much gone.

After sharing this with his doctor, the doc put him on Wellbutrin SR, 2x/day, 200mg/time. This just happened today, so he hasn't started the dosage yet. We are wondering how he should time his doses to facilitate maximum concentration at work for the maximum amount of hours. If he needs to work till 7 or 8pm - this has previously been impossible on XL because it has worn off, leaving him unable to focus past 5pm. He's hoping to time doses of SR so that working late, and concentrating while doing so, will be possible. We know it needs to be 6-10 hrs apart - but should he still take the SR at night so it can kick in first thing in the morning? Should he take it in the morning because it will kick in sooner than XL does? How long should he expect to feel the effects of a dose of SR?

The doctor had little to no input on this. So I'm hoping someone here can answer my questions:

1. *How much* faster does SR release than XL? Like, would a dose of SR taken at 3 am make one peak at 8am or at noon? and when would that dose's effects stop being felt?

2. Would a dose of SR taken at noon make one only start feeling that dose's effects a few hours later (making a person who works "lose a few hours" in the afternoon before the SR would kick in)? For how long, in the course of the day, does one usually feel the effects of Wellbutrin SR?

Ask the pharmacist for the inserts from the manufacturer (or maybe you can find them online). I believe they include a section with results of studies on average blood levels of the medication over a 24 hour period. That might give you an idea, but I think each person responds differently to some degree.

I never noticed that the XL wore off, though if it did, I might have associated it with normal fatigue at the end of the day. I felt more peaks and valleys when I was on SR, but it was partly because I didn't always take my pills at the same time of day.

Note, XL comes in 150 mg pills too. So if the SR 200+200 is too much for him (e.g. disrupts his sleep or makes him irritable) then he might try taking one XL 150 at night, and another in the morning. That should smooth out the results.

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