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Four hour efficacy is what you can expect from an instant release stimulant med. I don't believe that there is any way to extend this effect, as it's based on the amount of time it takes your body to metabolize the medication, and slowing your metabolism isn't generally something you want to do. Because an IR formulation will wear off after four hours, many of us take doses three times a day. In my case, I take Dexedrine at four hour intervals, 15mg at 8am, 15mg at noon and 10mg at 4pm.

Stimulant meds are [i]supposed[/i] to work with full effect the first time you take them, but I find that in my own experience I get the best effects after several days of taking the medication regularly.

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