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My son has never taken the Ritalin SR, but he has taken Ritalin, Ritalin LA, and Concerta (which I believe is a time-release Ritalin). My understanding about the differences among them all is the way the doses are released. Concerta worked wonderfully for his ADHD and lasted a full 12 hours, but left him with insomnia and no appetite. The Ritalin works fine but, of course, he must take it every 4 hours. The Ritalin LA made him jittery and spaced out.

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