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Something that is really helpful when wanting to come off of strong opiates (as opposed to methadone, which is notorious for its extremely unpleasant and long lasting withdrawals) is a drug called Suboxone (buprinorphine and naltrexone) , or Subutex (buprinorphine) . These are semi-active opioid inhibitors. The way they work is that they bind to the brain's opioid receptors, and basically block the activity of fully active opiates when ingested; that is - while taking the subutex/suboxone, you would not feel the effects of any opiates, and since buprinorphine is a semi-active opiate, you would not experience withdrawals, nor would you get the depression typically associated with quitting opiates cold turkey (once the physical W/D is over...).

The difference between Subutex and Suboxone is that the latter contains naltrexone (a.k.a. Narcan - given to opiate overdose patients) in a small enough dose to not be active if used properly; but which (unfortunately) is included to deter the person taking it from using fully active opiates by causing the body to go into instant physical withdrawals if he/she ingests any opiates (pretty quickly too, I might add); additionally since Narcan is a fully active opiate antagonist/blocker once the opiate withdrawal is initiated the use of more opiates only serves to make the body go into withdrawal worse. So it's a pretty good incentive not to relapse.

Ingestion of subutex/suboxone is really simple - it's a sublingually taken tablet that you take after abstaining from opiates for at least 24 hours (to prevent the narcan from inducing W/D symptoms) - you just let it dissolve under your tongue and that's it.

As far as getting off of subutex/suboxone, the withdrawals from buprinorphine are really mild because it's only semi-active as an opioid. I can tell you this from personal experience, because I was on a relatively high dose of suboxone (24 mgs/day) and only felt mild W/D symptoms after stopping flat out. Of course, one could also choose to taper off as well.

I found that taking suboxone was really helpful, much more so than methadone, because with subutex/suboxone you don't end up still feeling opiated, and thus I could function just as if I had taken nothing, but having no symptoms of WD's, and no depression from the chemical imbalance and low natural endorphine/dopamine levels associated with the cessation of opiate use.

I hope this advice helps, good luck to you! :-)


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