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Addison's Disease Message Board


Addison's Disease Board Index


GO TO: [url="http://www.pituitarydisorder.net/id48.htm"]http://www.pituitarydisorder.net/id48.htm[/url] for more information on Cushing's disease. Print this information and take it to your doctor. You should be getting better by now!!!

Symptoms of Cushing's disease

The symptoms caused by excessive cortisol secretion may vary from person to person. Many of the symptoms listed below can be attributed to numerous other diseases if viewed separately. However, several of these symptoms seen together could suggest testing for Cushing's disease.

Moon Face - The face becomes round and may look flushed.

High Blood Pressure- Almost all patients with Cushing's have high blood pressure because of complex actions of cortisol in the kidney and on blood vessels.

High Cholesterol - The high blood pressure interacts with high cholesterol levels that are often seen in patients with Cushing's to increase the risk of
atherosclerosis.

High Blood Sugar - Diabetes is common in patients with Cushing's. As many as 3% of uncontrolled diabetics may actually have Cushing's. The disorder is due to the effects of cortisol on insulin action and handling of glucose.

Truncal Obesity - An accumulation of fat around the abdomen, neck and collar bone.

Muscle Weakness - Legs and arms lose muscle mass and appear thin in comparison to trunk.

Backaches - Pain in neck shoulders and back are common in Cushing's.

Buffalo Hump - Fat can accumulate at the back of the neck and between the shoulder blades.

Skin Changes - Skin may become thin, fragile and easily bruised. Acne may develop in all ages.

Straie - Bluish-red stretch marks may form on abdomen, breast, thighs, upper arms and buttocks.

Weak Immune System - Poor wound healing and increased chances of infections.

Menstrual Periods - Periods may be irregular or cease.

Labedo - Lack of sexual desire for men & women. Men may have difficulty maintaining an erection.

Hirsutism - Abnormal hair growth on face.

Balding - Hair at temples and on the scalp may become thin.

Emotional Disturbances - Mood swings, depression, irritability, confusion, and poor memory.

Extreme Fatigue - Weakness and fatigue during the day and difficulty sleeping at night.

Osteoporosis - Fragile thinning bones. Bones loose their density and may fracture or break.

Kidney Stones These are often the first manifestation of Cushing's syndrome. The calcium that comes from the bones leaks through the kidneys into the urine and can crystallize causing calcium stones.

Some patients have sustained high cortisol levels without the symptoms of Cushing’s syndrome or disease. These high cortisol levels may be compensating for the body’s resistance to cortisol’s effects. This rare syndrome of cortisol resistance is a genetic condition that causes hypertension and chronic androgen excess.

Polycystic ovarian syndrome is another condition that may share some of the same symptoms as Cushing’s. Patients with polycystic ovarian syndrome have menstrual disturbances, facial hair, weight gain, high blood pressure and high cholesterol. Polycystic ovarian syndrome does not cause abnormally high cortisol levels.





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