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Addison's Disease Message Board

Addison's Disease Board Index

First off, no one knows what the proper dose for Addison's is. It is thought to be around 0.18mg/pound of weight so a 150 pound person should be around 25mg/day. But a normal body regulates cortisol on a minute by minute basis and can sometimes triple or more the dose you receive. Of course you can't do that because the need for more cortisol is not directly obvious. Worse, the dose that makes you feel find today, might be too big or small tomorrow when you get an infection or the flu.

So what I am saying is, you won't be able to find the perfect amount, but it is somewhere between 15 and 30 mg/day for most people. It used to be thought you should try to be as low as possible, but now people wonder if being too low harms your immune system because cortisol is a powerful regulator of immunity.

Normally, when you get sick, cortisol goes high for a day or two and then suddenly drops. The drop signals your immune system to go into high gear and attack the virus/bacteria you have. This also happens at night when your immune system ramps up as the cortisol levels plunge. That's why it's wise to take most cortisol in the morning and little at night and to take more cortisol when you get sick and then drop it after a few days.

Your thyroid dose is a bit easier because you can take blood tests for that. However the normal range of thyroid is pretty wide so what makes one person feel energetic won't for another. Again, you will have to experiment, remembering that changes take a week to come into full effect and not to change by more than 0.025mg/2 weeks. Watch for symptoms of high and low thyroid incase you go too far.

It took me 2 years to balance my hormones. I now take 25mg/day of hydrocortisone and 0.175mg of synthroid. My original starting dose was 15mg/day and 0.1mg. Both doses gave me normal blood readings.

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