It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Addison's Disease Message Board


Addison's Disease Board Index


[QUOTE=suz9601]What can be done to lower DHEA levels? Mine are very high, that could be why I dont have any cortisol. It lowers it right? Just wondered if you knew of anything to lower it, or why it goes high?[/QUOTE]

The hormone ATCH controls both the DHEA and cortisol levels. The fact you have high DHEA and low corisol is not normal. You need to investigate the cause of the excess DHEA. There are several possibilities including several cancers, so you shouldn't be fooling around taking things to mask the problem.
Get to your doctor and find out what's going on.
The problem with urine tests is that concentrations of *anything* depend on how much water you're putting out. To get quantitative information from urine tests, you need to consider ratios, or consider a 24-hour output.

If you've got high levels of DHEA, T3, T4 I'd just consider your urine concentrated, if it fits in with a pattern of other things being on the high side.

If this is a *24-hour* urine sample, what you're doctor is looking for is your daily total output, and that's a different story. I don't remember how the thyroid hormones vary during the day, but it may be relevant. (I don't think I ever knew how DHEA is regulated -- I'd be curious if someone happens to know).
[QUOTE=rwk] (I don't think I ever knew how DHEA is regulated -- I'd be curious if someone happens to know).[/QUOTE]

DHEA output is normally controlled by the pitutiary. It puts out ATCH which stimulates both cortisol and DHEA output from a small area above the kidneys. Those two hormones normally rise and fall together.

However, certain tumors can also create DHEA and those tumors don't respond to ATCH at all. I believe breast cancer can be associated with high levels of DHEA in the blood. I don't know what would cause high levels in urine and not the blood.
[QUOTE]DHEA output is normally controlled by the pitutiary. It puts out ATCH which stimulates both cortisol and DHEA output from a small area above the kidneys. Those two hormones normally rise and fall together.
[/QUOTE]

Um, er, I DID know that. Guess my memory really IS shot! Thanks. Do you know if ACTH is the only regulation? There's no feedback from DHEA levels, right? So if DHEA is high or low (relative to cortisol) there's no corrective action?

That would mean that adding glucocorticoids would actually [I]depress[/I] DHEA by shutting down CRH/ACTH/DHEA, right?

Further implying that taking prednisone for asthma, say, would induce a DHEA deficiency?

Hmm. Never thought through this chain before -- or I'd have remembered the first part.

Thanks! (But now I have even more questions :confused:)
[QUOTE=rwk] Do you know if ACTH is the only regulation? There's no feedback from DHEA levels, right? So if DHEA is high or low (relative to cortisol) there's no corrective action? That would mean that adding glucocorticoids would actually [I]depress[/I] DHEA by shutting down CRH/ACTH/DHEA, right? Further implying that taking prednisone for asthma, say, would induce a DHEA deficiency?
[/QUOTE]

Yep, you got it right. DHEA does not have a feedback loop, the body seems to rely on cortisol for that. And yes, taking prednisone will cut off your DHEA supply and produce a deficiency.





All times are GMT -7. The time now is 07:43 PM.





2019 MH Sub I, LLC dba Internet Brands. All rights reserved.
Do not copy or redistribute in any form!