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Addison's Disease Message Board


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I have adrenal disease. I have read the posts here, particulary by Chris in St. Louis and found them very helpful. I take DHEA, thyroid, and prednisone. There are times I have been able to get off the prednisone and just stay on the DHEA, but when my adrenals get overstressed I have to go back on the prednisone. Prednisone, cortisol, or the like, all give me muscle aches (and I have to cease any exercising) but not the DHEA alone.

I have been experimenting with taking mega doses of DHEA during an adrenal crises so as not to have to take prednisone. I usually take 100 mg DHEA every 8 hours during non-crises times. Any ideas how much I should take during a crises? And does anyone know if DHEA can give the adrenals the same kind of support as prednisone and the like and how much DHEA would equal how much prednisone? Approximately speaking that is. Any other ideas?

Thanks, AdrenalMan
[QUOTE]DHEA output is normally controlled by the pitutiary. It puts out ATCH which stimulates both cortisol and DHEA output from a small area above the kidneys. Those two hormones normally rise and fall together.
[/QUOTE]

Um, er, I DID know that. Guess my memory really IS shot! Thanks. Do you know if ACTH is the only regulation? There's no feedback from DHEA levels, right? So if DHEA is high or low (relative to cortisol) there's no corrective action?

That would mean that adding glucocorticoids would actually [I]depress[/I] DHEA by shutting down CRH/ACTH/DHEA, right?

Further implying that taking prednisone for asthma, say, would induce a DHEA deficiency?

Hmm. Never thought through this chain before -- or I'd have remembered the first part.

Thanks! (But now I have even more questions :confused:)
[QUOTE=rwk] Do you know if ACTH is the only regulation? There's no feedback from DHEA levels, right? So if DHEA is high or low (relative to cortisol) there's no corrective action? That would mean that adding glucocorticoids would actually [I]depress[/I] DHEA by shutting down CRH/ACTH/DHEA, right? Further implying that taking prednisone for asthma, say, would induce a DHEA deficiency?
[/QUOTE]

Yep, you got it right. DHEA does not have a feedback loop, the body seems to rely on cortisol for that. And yes, taking prednisone will cut off your DHEA supply and produce a deficiency.





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