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Addison's Disease Message Board

Addison's Disease Board Index

I'm having the same problem of figuring out which came first the chicken or the egg on this. I have high Cortisol levels and DHEA levels as well. Not sure if the hypothryodism is causing this or something else.

I'm a male, but have the same problem as you. My endo is doing further testing to rule out cushing's disease or some other chronic illness causing the high cortisol and DHEA levels. Have you found out any additional info from your doctor. Mine is going to run a 2-day dex suppression test followed by CRH stimulation.

Were you switching your dosage during the high cortisol level results. Reason I ask is that I have always had a hard time tolerating thyroid med increases and think it causes my adrenals to overstimulate thus result in the high levels. I have been making med increases since Feb this year, and that may be causing the high levels. But, I also heard that undermedicated hypo causes cortisol levels to be high to compensate for lack of hormone.

All I know I is that I don't want to go to end up down the Cushing's disease path. The stories from those folks are beyond frightening compared to thyroid disease.

Here are my test results:

Cortisol, Salivary

12:00 AM 690 NG/ML Range 50-250 NG/ML
8:00 AM 1903 NG/ML Range 200-1600 NG/ML
4:00 PM 1098 NG/ML Range 100-600 NG/ML

ACTH Plasma test done the same day and results:
ACTH, Plasma 11 PG/ML <5.0 - 60.0

Cortisol, Free Urine 116 H (range 20-90)

And other tests supporting an adrenal/hormonal problem:

Renin, Plasma Activity 4.6 H (range 0.2 – 3.0)
DHEA Sulfate 663 H (range 59-452)
Cortisol, Total AM 17.7 (range 4 – 22) Note that lower than upper limit but Endo said that this is still a very high morning level. Said he doesn’t see it that high very often.

Kind Regards,


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