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Addison's Disease Message Board


Addison's Disease Board Index


mngirl, I just found this info on the test you will be having. I hope it is helpful to you.


The overnight metyrapone test:

OBJECT: This test is an alternative to the insulin test mentioned above and has basically the same objective which is to determine if the pituitary is making ACTH in response to a stimulus. Metyrapone is a drug that blocks the last step of the synthesis of cortisol in the adrenal gland.

THE TEST: The patient is given 30 mg/kg(body weight) at midnight without food. Blood is drawn at 8 AM ad the levels of cortisol and 11-deoxycortisol are measured.

NORMAL RESULTS: A normal individual will show morning plasma cortisol levels below 10 ug/dL (276 nmol/L) and 11-deoxycortisol levels at 7-22 ug/dL (0.2 to 0.6 umol/L).

DISEASED PATIENT: A patient with HPA axis impairment will not show increased levels of 11-deoxycortisol. NOTE: This test can drive a patient into adrenal crisis!!!

REASON FOR ABNORMALITY: same as above, no ACTH production





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