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Addison's Disease Message Board

Addison's Disease Board Index

Renin angiotensin aldosterone system

Simplified very greatly, renin, an enzyme, converts angiotensinogen (found in lungs) to angiotensin I via the liver. Angiotensin converting enzyme (ACE) converts Angiotensin I to Angiotensin II which with the help of corticosterone converts to aldosterone which regulates sodium and cloride reabsorption, potassium excretion, all which in turn regulates water retention. This system works with the pituitary hormone, vasopressin.

As aldosterone goes down, so does sodium and water retention. This can cause low or high blood pressure depending on high messed up the mechanism is. If aldosterone and sodium are down slightly, blood pressure can go down a bit, so the heart pumps faster to get the blood pressure up. The heart may pump to fast and blood pressure can go to high.

If aldosterone and sodium are very low, blood pressure can go very low and the heart pumps faster, but not fast enough to raise blood pressure to normal.

A long time ago, I figured this mechanism may be the cause of migraines. The next person that said they had migraines, I recommended they try drinking salt water and get back to me. They reported the salt water elminated their migraine within 3 minutes each time. I then recommended they try drinking salt water in the morning as a preventative and they reported this seemed to help lesson the number of and severity of their migraines.

As I ran into people who reported they had migraines I continued to recommended salt water and all (about 10 so far) report the salt water helped them. I've been told that salt water works for regular headaches as well. My daughter tends to get headaches and she told me salt water helps her rid the headache right away.

You need to get a hold of any thyroid tests that were done on your son. Post them here and the Thyroid forum. Get several opinions. Most docs won't say their is a problem unless the numbered are outside the flawed ranges. 95% of those with hypothyroid are in range. Check out the thyroid forum and you'll see that most on there are in range and report they were told their thyroid was fine even though they had classic symptoms of hypothyroid.

His cushinoid appearance will probably go away with time (within a year or few months) once cortisol is lowered. Cushingoid appearance does not happen with AI. There is something called cyclical cushing's (usually caused by acth secreting pituitary tumor) which can cause cushingoid appearance

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