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Addison's Disease Message Board

Addison's Disease Board Index

This is my experience. I have had urine tests effected by the lab having them sit out after I brought them in refridgerated. That *appeared* to make my tests come in lower but since I could not say for sure they were mishandled nor could I get a good sample from a chilled one, there is no way to know. All I know is that when I took my tests to a doc or lab and I saw them process it in front of me, my tests tended to be higher and when jugs were taken away and just set away, they tended to be lower. I only got high results from properly handled specimens. Also, some of the preservatives can interfere with the testing - none, or one of them is ok, but one of them will kill the test. I cannot remember what it is off the top of my head.

As for the cortisol blood test, it has to be done at certain times of day to be diagnostic. Fasting is preferred but not mandatory but my better docs want an 8am fasting, or 4pm (this is usually not fasting). Why this timing - to coincide with the body's diurnal rhythm. 8am should be the highest and 4pm should be roughly half. Abnormal is to have them the same or the 8am to be low. Loss of rhythm is telling as well. Many doctors like to do midnights as well and also this can be accomplished with saliva testing but saliva tests free cortisol will blood is serum (both cortisol but different forms and some people do not "spill" free cortisol hence will not get high UFCs or saliva tests due to medications or other reasons just due to their bodies - it can happen - high cortisol binding globulin). Midnight should be close to one. That is how you sleep. It then rises during the night and gets you up in the morning. It then falls naturally during the day. This is a normal person.

Usually a good endo will repeat the tests multiple times anyway - once is not enough.

The challenge with the stim test is that the ingrediant used to do the stim - CRH - is in shortage. It is a chronic thing.

Sorry to hear your son has problems.

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