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I just posted this on the other thread.

My cortisol was at 5 % in the blood serum and only in normal region at 8 am. After i take my DHEA supplementation. ACTH Stim high.. 70 when normal <35

I am vit D deficient. Now aggressively treating this. Doesn't help the hypoT constipation issues.
I was vit B12, ferritin, and magnesium deficient.. But I have gotten those into the 40% range of normal and holding six months now.

My Hashimoto's antibodies are about 2000.
My CSF is at an elevated pressure and I have oligomeric banding and noted milan destruction.. MRI is clean.. as well as a bunch of other tests.. no MS or lupus.. so Hashimoto's encephalopathy is suspected. Go back in May for another round of testing on that one.

I am having issues with regulating thyroid meds because my T3 levels are/were 2 fold my T4 levels and I keep pushing my self hyperT in T3 while remaining hypoT in T4.

My endo claims I am normal because my TSH was 2 before meds.. all else was irrelevent. Bless her. So I am working with my IM and we are both in new territory. Know any good Endos with in 4 hours of Chattanooga, TN with this mess.

Right now my list is:
Thyroid: TPOAb, TGAb, TBG, TSH 3rd Gen, Ft3, Ft4, T2

Adrenals: ACTH, Cortisol 8 am, Aldosterone, and ACA, renin

Pituitary/hypothalamus: PTH, TRH

General AI: ANA

So anything I am missing? I am giving my blood chemistry a good 3 months to level out and equilibrate. So the Vit D and other mess will wait. Also any advice in getting rid of the water retention in the feet? Just the feet and my right ankle. Ocassionally my knees swell but that normally corresponds to a Hashi's flare and hypoT state. AHHHH! Okay better now. Crud.. I think I am working up to a hyperT swing again. This really sucks.

As too my Ca, Mg, K levels. The used to be high normal.. now they are dropping. Head injuries are a nil. Here is a familial kicker for you. My mom and one of her 4 sister's are Hashi's and Graves. Two more aunts are Hashi's and one is Graves. All five have AI's. None have exceeded a TSH of 2.5 even after a thyroidectomy or RAI was performed. ;) Secondary hypoT runs rampant with us. My mom's top TSH was 2.33 with only half a thyroid and an RAI uptake showing the remaining lobe dead. Aunt B1 2 RAIs and finally a TT max TSH 2.54. My Aunt B2.. due her TT max TSH 2.67. My max before meds 2.077. It is true I have yet to find a AI marker for secondary hypoT. However.. TPOAbs have been known to interfere with TSH binding receptors.. so maybe they work in two ways.

MG
My DHEA is low normal.. my ACTH is about 200+% of range. So they do not have to be parallel in range.

My cortisol is lower.. and with regards to the ACTH it means as you say.. your pituitary is telling it to make more.. but the adrenals just can not put out. I need to now test the aldosterone and other home made steriods to see if it is an isolated phenomena. You should do the same.

The human adrenal cortex produces aldosterone, cortisol and the so-called adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). We know you are low in cortisol and high in DHEA.

I do not know about the others for you or me. My IM was humoring me when she ran the others and I was right again. Which got a snort and grin and a you know as much if not more than me out of her. I told her not true.. i do not know more about medicine, I am just ground zero to my symptoms and a a.retentive chemist. I am going to have to do some digging into the mechanistic theory you have proposed here. May take me a few days. But it sounds good. ;)

Pregnenolone is a natural hormone made from cholesterol in the body. Pregnenolone is an intermediate in the synthesis of all steroid hormones. It is synthesized inside the mitochondria, the tiny "power plants" found in each cell. Pregnenolone is synthesized from cholesterol and is a precursor for the biosynthesis of steroid hormones. Pregnenolone is the basic precursor for the production of all the human steroid hormones, including DHEA, progesterone, estrogen, testosterone, cortisone, cortisol and aldosterone. Its levels are highest in the brain and studies have shown that it enhances many of our mental functions.

Conclusions: Low pregnenolone can mean a deficiency in any of the hormones it is a precurser for. What minerals and limiting reagents does our body need to convert it to cortisone, cortisol.. etc. Maybe it is a blood chemistry thing aggravating issues. Once again the endocrine system is far from A + B = C.

The thyroid hormone T2 is suspected to be a driving force in this. Since your hormones are off yhou may need to look into your T2 levels. T0-T2 were once thought of as inactive.. however.. T2 has been found integral on a cellular level. SO a good look at the thyroid which is just as tied into the adrenals and pituitary/hypothalumus cogs as well may be helpful. The endocrine sysdtem is a delicate balance of everything.. somethings a fix of the thyroid makes everything else behave.. others require more attention. Who KNOWS.. we have to make hypotheses and run them all out to conclusion.

Here is a tangent for you.;) I am good at those.. it is a blonde moment. I will dig more into the mechanisms.. but you are looking sound given the data you have. Me? I am just screwed up. :D

Dug up this fact from and NIH reference.. "Similar to the adrenal gland, there is an intradermal neuro-immune network involving the local expression of cytokines and neuropeptides. Dysregulation of androgens in the adrenals and/or the skin is associated with acne, hirsutism and androgenic alopecia." I have had an increase in acne of late.. not a normal occurance. Maybe the DHEA supplementation and HC is causing a temporary inbalance.

MG





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