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Addison's Disease Message Board

Addison's Disease Board Index

It looks like you and I have similar results compared to our normal ranges. I've been taking DHEA and Pregnenolone though since my doctor won't prescribe Cortisol. It looks like it caused my T3 to drop so I increased my Armour. It only helps a little to get me out of bed in the morning though. I can't wake up. Can you wake up in the morning? Does the cortisol medicine help you to wake up?
That's exactly how I feel. Wake up late, drag all day at work and then feel pretty good at night. I've been taking DHEA and Pregnenolone to support my adrenals but they don't seem to be doing anything. Will you please post here how the Cortisol works for you when you give it enough time? Thanks.
Cortisol was like instant sugar in my veins. I was tired and fatigued all day with out it. I dragged about and would be forced to nap in the afternoons with my son. I also would pass out early in the evenings. I had NO energy before taking cortisol. My DHEA levels were high due to PCOS. My cortisol was in the pits. I tried the DHEA route and would have tried the pregnenolone, but my IM noted that all my pregnenolone was being filtered into DHEA, estrogen, and testosterone. As a result supplementing pregnenolone did not help me.. only cortisol did.

As to how cortisol can affect ones T3 levels. Well the addition of pregnenolone, cortisol or aldosterone suppress T4 to T3 conversion. If you are seeing a depression of your T3 levels you should be seeing a corresponding rise in T4 levels. If you are not noting this, something else is up.

I hope that you get relief soon. I know how bad it is to live with untreated adrenal and insulin issues. Needless to say I was a brain dead, semi-comatose zombie.

[B]I am hypothyroid and I read a lot of people have adrenal issues with their thyroid problems. My doctor won't treat my adrenal glands based on the results below but I would appreciate a second opinion from you all. The lab is a 24 hour saliva test.
Optimal range for most is in the 40-60% region of normal.

When are you taking your pregnenolone and DHEA? How much are you taking at time X? It can make a difference.

[B]7:00 am Cortisol 0.10 mcg/dL (0.04-0.56 is normal) [/B] You are at 11% or the normal range here.
[B]12:00 pm Cortisol 0.14 mcg/dL (0.04-0.56 is normal)[/B] You are boosted to 19 % of normal here.
[B]5:00 pm Cortisol 0.15 mcg/dL (<0.15 is normal)[/B] You are at 100% of normal range. This is what is interfering with your sleep pattern you are spiking at an odd time during the day.
10:00 pm Cortisol 0.07 mcg/dL (<0.09 is normal)[/B] You are at 77% of normal here. Still high optimal in range. Pregnenolone has a longer delay to get into your system. When taking it you have to account for the fact that you have to absorb it and then you adrenals have to take it and convert it into aldosterone and cortisol.

In theory your highest level should be first thing in the morning around 8 am. This is not the case with you. You climb to your highest point after waking. Depending on when you take your meds and the inherent delay time in conversion. It may be better for you to take your pregnenolone at bed time and then your body will be able to convert it to cortisol while you sleep. This is just theory. It would help to know when you take X and how much.

Orion makes a good point about the ACTH stimulation test with hormone evaluation. It is the only true way to determine if you have bult adrenal hypofunction or a genetic flaw in your conversion process. There are MANY steriods and hormones produced by the adrenals. The chemical reactions are in a state of flux and equilibrium. It is hard to know for sure what is going on when and how supplementation will affect things. In your case you are low on cortisol in the mornings. I think you would benefit for 10 mcgs of cortisol first thing in the morning. I do not know if your MD will look into it further for you though. BEFORE you can be effectively tested for adrenal issues you would have to be off DHEA and pregnenolone for AT LEAST 4-6 weeks. It takes that long to leave the adrenals to their own devices so an accurate functionality can be tested. I wish I could be of more help.

Honestly not yet. I've tried many things though. DHEA, Prednisone, Pregnenalone and now Adrenal Extract. I finally found a doctor in my area that believes in adrenal fatigue and is treating me for it. He is confident that I need adrenal support, which is great to finally hear. He says that he's seen it before and he is confident that he can help. I saw him 1.5 weeks ago and I still feel crummy. He also changed my thyroid medicine so that may be contributing to why I still don't feel better. I need to get on with my life though so I hope it works. I found him by contacting a compounding pharmacy in my area and asking them who treats adrenal fatigue. It was pretty simple. I wish I did it a long time ago.

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