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My mother has been getting blood transfusions for sideroblastic anemia for over seven years up to twice a month.

The short history is as follows:

- Sideroblastic Anemia was acquired from what theey do not know.
- There is no cure only treatment of effects
- Effects are Red blood cells not living to maturity, resulting in lower oxygen carrying agents in the blood.

In the beginning the a bone marrow transplant (which makes red blood cells) was the alternative to blood transfusions. the reason it was not attempted was the risk is very high to do a transplant as you are subjected to chemotherapy to kill all bone marrow cells, as well as many others, and bascially then have to hope the donor's marrow will graft to your bones and function. At the time, transfusions were a better alternative as it was managable, low risk, and a cure could actually be around the corner. Over the years we had tried many experimaental medications.

The point:

The results of prolonged blood transfusions have created a dire situation. The resulting iron overload even with treatment has become unmanagable. The resulting effects include primarily an enlarged heart which is now diagnosed as Congenitive heart failure. Basically the heart enlarged due to the iron and the vlaves did not enlarge with the heart resulting in low blood pressure. this low blood pressure has coupled with anemia has created a very detrimental circumstance. The bodies reduction in oxygen has lead to water retntion throughout the body and organ failure including renal failure in the kidneys and liver problems. The water retention does not allow the body to filter properly. The medication to remove water retention actually causes low blood pressure so it is a catch 22.

My question:

Has anyone experienced the effects of prolonged blood tranfusions over years?
If so, what were the results?

Thanks for your attention.
[QUOTE=icemanj;3018984]My mother has been getting blood transfusions for sideroblastic anemia for over seven years up to twice a month.

The short history is as follows:

- Sideroblastic Anemia was acquired from what theey do not know.
- There is no cure only treatment of effects
- Effects are Red blood cells not living to maturity, resulting in lower oxygen carrying agents in the blood.

In the beginning the a bone marrow transplant (which makes red blood cells) was the alternative to blood transfusions. the reason it was not attempted was the risk is very high to do a transplant as you are subjected to chemotherapy to kill all bone marrow cells, as well as many others, and bascially then have to hope the donor's marrow will graft to your bones and function. At the time, transfusions were a better alternative as it was managable, low risk, and a cure could actually be around the corner. Over the years we had tried many experimaental medications.

The point:

The results of prolonged blood transfusions have created a dire situation. The resulting iron overload even with treatment has become unmanagable. The resulting effects include primarily an enlarged heart which is now diagnosed as Congenitive heart failure. Basically the heart enlarged due to the iron and the vlaves did not enlarge with the heart resulting in low blood pressure. this low blood pressure has coupled with anemia has created a very detrimental circumstance. The bodies reduction in oxygen has lead to water retntion throughout the body and organ failure including renal failure in the kidneys and liver problems. The water retention does not allow the body to filter properly. The medication to remove water retention actually causes low blood pressure so it is a catch 22.

My question:

Has anyone experienced the effects of prolonged blood tranfusions over years?
If so, what were the results?

Thanks for your attention.[/QUOTE]
That is a bad situation for you and your mother to have to go through. I do know that it might be worth investigating to see if they can use another blood substitute instead of blood transfusions at this time. Also you might want to ask your doctor about iron chelation therapy before the next transfusion is necessary. As for the damage done, some of us will have some heart failure from natural aging but it sounds like you and she are having very hard times. The best wishes are for better times ahead.





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