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Hi Herekittykitty

[[B]B][COLOR="Red"]HKK: I see what you mean--I guess it really wouldn't hurt to do a simple test like a B12. The other thing about the symptoms you mention: remember that even though you have family members who have pernicious anemia with B12 deficiency, it STILL doesn't mean your symptoms are from that even if they had them. In fact, unless you have severe B12 deficiency with symptoms of cerebellar and dorsal-column spinal cord degeneration, the rest of the symptoms you describe (except for maybe the numbness in the hands) are not typical.[/COLOR][/B][/B]

I do not agree with this comment put up for you from another poster your symptoms inc numb hands are symptoms of B12 deficiency it causes sooo many symptoms all taht you mention the only one that doesnt fit is swollen eyelids taht I know of but it is possible as it does affect the eyes in fact it affects every system in our bodies it is a very important vitamin and you dont have to have anemia to have it.....there is a strong link between B12 and thyriod problems

Good luck if your doc wont test which is just plain silly then see another......Do all the research you can on it and make sure your supplementing with Methylcobalamin the active form pretty much anything else will not bring the repair you are wanting there are also a lot of cofactors involved the B12 that need to be taken as well........To repair damage you will need large doses consistently and it can take many months......
I appreciate what you are saying, but when someone has B12 deficiency as a cause of anemia, you don't need a B12 level to be able to rule it out. B12 deficiency has to be severe and longstanding in order to cause the megaloblastic changes and neutrophilic hypersegmentation seen in the complete blood count. If you understand all the different parameters that HKK has included in her bloodwork, it is clear that at least her anemia is not secondary to B12 deficiency.

You are right, however, you can have neurological symptoms of B12 deficiency in the absence of anemia, but that is relatively uncommon. I appreciate you were having a myriad of symptoms, but again if you read my comments about specificity of different symptoms, all of your symptoms are non-specific. The symptoms you name have just as good a chance of being from any other health condition you have/had, as from the B12 deficiency.

I agree with you that B12 has a widespread role in the body aside from just the blood, and this is because it is used in a critical step in DNA synthesis. The classic two systems which are affected from B12 deficiency are your hematologic system (generally one gets a megaloblastic anemia) and the nervous system (both the peripheral and central nerves). Other systems are definitely affected, but in a much more non-specific way. Because B12 deficiency will affect areas of the body where there are rapidly growing cells, other things which can happen include: atrophic vaginitis, chronic abdominal pain, nausea, hair loss etc.

I don't want to trivialize your condition as you obviously have had trouble and were being treated for it, but your case is not representative of the vast majority of people who have severe B12 deficiency from many causes: Crohn's terminal ileitis, Diphyllobothriasis, Short gut syndrome, pernicious anemia, achlohydria etc. etc. A small amount of medical training will allow one to interpret HKK's CBC and see that it is not from B12 deficiency.
[QUOTE=cgranulomatis;3877634].... The symptoms you name have just as good a chance of being from any other health condition you have/had, as from the B12 deficiency....[/QUOTE].
Exactly!

[QUOTE]... but your case is not representative of the vast majority of people who have severe B12 deficiency from many causes: Crohn's terminal ileitis, Diphyllobothriasis, Short gut syndrome, pernicious anemia, achlohydria etc. etc. A small amount of medical training will allow one to interpret HKK's CBC and see that it is not from B12 deficiency.[/QUOTE]

Yes, I am in total agreement.
[QUOTE=cgranulomatis;3877812]Rainbow, trust me when I say I've done my share of reading about Vit B12 deficiency given what I do ;) I also think we were talking about two different things. You were talking about her symptoms, and I was talking directly about her anemia.

I left a LOT of things off the list that can potentially cause Vit B12 deficiency. You bring up an interesting point with celiac disease (CD). CD in itself doesn't directly cause vitamin B12 deficiency, but it can be associated with certain other autoimmune conditions, such as pernicious anemia, which can obviously cause cobalamin deficiency. The nutritional deficiency most associated with CD is iron deficiency. As a result, any adult with occult iron deficiency should be first screened for colon cancer and secondly for CD. CD can also be associated with bacterial overgrowth and blind loops, both of which directly cause cobalamin deficiency, but again, CD in itself does not.

HKK, I hope your anemia is sorted out and that you feel better soon! Just out of curiosity, you say you were having very heavy periods, has this ever been investigated?[/QUOTE]

Wrong again Cd causes malabsorption making the use of B12 and iron impossible as it damages the small intestine the lower end one place were B12 is absorbed... so if that isnt directly causing it I dont know what is it is very common in CD lots of us have it .....as well as iron......There are many things that cause B12 def including inborn errors





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