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Yes I think you can switch right over from Zoloft to Lexapro. I was able to switch right over from Lexapro to Celexa. These are all ssri's. Surprisingly though, you cant switch from Celexa to Lexapro (because of an isomer in the Celexa.) But reversed, you can. Very strange. You know, it is so important to have a doctor who does understand these medications because it makes a huge difference. Like the last post said, why didnt your doctor just up your Zoloft dose? If Zoloft works well for you (which i dont know if it does or not), an increase in the Zoloft would only make sense. Lexapro is great, dont get me wrong (I take Lexapro devotedly 10mg daily) but if Zoloft works for you I would think an increase would be best....unless of course you are interested in switching to Lexapro?

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