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Just another story to reference. I had a manic episode with no prior history of psychological disorders. Then, post-episode, I had pretty severe depression where I wanted to stay in bed all day. After begging my doctor and trying to be without it, I was put on Zoloft and it was moved up to 150mg a day. It took 4-6 weeks to kick in and after about a month, I was slowly came down to 100mg for a week, then 50mg per week, then 25mg per week, and then done. After that, I was off of it for a year but during the following winter, I felt very tired and lazy after a few hours of work so my doctor told me its depression but very mild. I got back on Zoloft 50mg and it was great and providing that extra boost of energy (or serotonin) with minor side effects for me.

Then, I recently ran out of Zoloft and had to wait for a mail order plus changed insurance, so my doctor gave me Lexapro 10mg samples to use until I can get more Zoloft. I used Lexapro 10mg per day at night (in replacement of Zoloft 50mg) for 3 weeks and for some strange reason, I feel its slowly making me depressed (as if its because of the Zoloft wearing off). So, today I quickly called the doctor after finally realizing it might be the problem and I'm getting back on Zoloft even if I have to pay out of pocket for now, because apparently I FEEL it works better on me than I've noticed the Lexapro doing.

My 2 cents...hope it helps!

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