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I have been on both of these meds, and many more. I have tried, effexor, paxil, wellbutrin, prozaz, lexapro, and zoloft, 1st, and now last.
Of course everyone is different, but I do like zoloft best, at first, it's somewhat tiring, however, it was worth it to me, it eases my anxiety, and depression. Weight gain was not a problem because of zoloft, my over eating was, and being lazy. I am 5'7, and weigh 140, so I gained about 3 lbs, it's well worth it. Lexapro was okay, but I still had some anxiety, and took it with diazepam, or lorazepam, and that's just to much pill popping for me. I suggest trying the zoloft at 50mg, then increasing if you need too. I felt better, but tired, within 2 days.
Hope this helped, and good luck!

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