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Here is my advice. I took Paxil for 12 years. At 5 years, it became less effective, and so my Pdoc augmented it with a low dose of Buspar. He said that they work well together, which is my experience. That way, I didn't have to increase the Paxil dosage.
The Paxil/Buspar stopped working for me after 12 years, so I started on Zoloft, which gives insomnia, but I guess some side effects are a fact of life with ADs.
No side effects are desireable. It's about what you can tolerate.
When taking Paxil I had restless legs, weight gain and sexual functioning problems. I had a short period after dropping Paxil where I dropped weight, sexual functioning improved a bit, and restless legs ran away.
So no, I don't think the side effects are permanent.

P.S. - I'm learning that daily exercise helps all ADs work better.

Good Luck:)

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