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It takes about 6 weeks for the Zoloft to work, this is what I found. The anxiety calmed down after a couple of weeks. I kept out of situations that made me worse for awhile. I was on effexor for a while, years ago. They took about the same time to work. 6 weeks was about the time it took for them to kick in. Good LUck, it can be a hard road. But you will get better. Its so good when the meds start working and the fog clears and you start to feel like your part of the world again.

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