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Apparently no one ever replied to you and the issue maybe moot. However, if it is not, for what it's worth, I have been on Methatrexate, Plaquenil, Presidone and biogics for several years. No radical side effects and the drugs have kept me functioning. Before the medicines I would have flares and couldn't even button my clothes or tie my shoes. At this point the RA is in check. Pain's controlled by Tylenol, and normal living functions are okay, some difficulty with grasping small items.

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