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Well I took it for about a year and I was so terrified I had to have my doctor on the phone as I swallowed the pills the first time. I had my husband and kids on standby in case of a bad reaction. I kept waiting and waiting and....nothing. I never had the slightest side effect. It worked pretty well for me but I have since switched to enbrel which is working great. Good luck! Just remember, no alcohol with methotrexate.

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