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High Cholesterol Message Board


High Cholesterol Board Index


Ed With Zocor
Oct 29, 2004
My husband suddenly developed ED after being on 40 mg of zocor for 3 weeks. He wanted me to ask if anyone else had experienced this and if so, did you find a remedy.
Re: Ed With Zocor
Oct 29, 2004
I'm not sure I have the solution to that problem, but I see how it is possible for Zocor to have such an effect. Cholesterol is needed in order to manufacture many hormones, including sex hormones. By artificially lowering cholesterol, the production of these hormones can also be diminished, particularly if cholesterol is lowered significantly.
Re: Ed With Zocor
Oct 29, 2004
jean,

The more likely cause is any of the high blood pressure meds. Is he on any of THEM?
Re: Ed With Zocor
Oct 29, 2004
Zip2play,

She did say that the problem started just 3 weeks after taking 40mg Zocor.
Re: Ed With Zocor
Oct 29, 2004
no blood pressure medicine - he does not have high blood pressure and recently underwent thallium stress test which was normal.
Re: Ed With Zocor
Oct 29, 2004
[QUOTE=jeankb]My husband suddenly developed ED after being on 40 mg of zocor for 3 weeks. He wanted me to ask if anyone else had experienced this and if so, did you find a remedy.[/QUOTE]

NO...absoultely not. But if he
is concerned... GET OFF Zocor and see. BTW..he should be on Vytorin...20mg Zocor combined with Zetia. Better results with LESS Zocor.
Re: Ed With Zocor
Oct 30, 2004
I'm with rahod.
If anyone suspects a new (or old) drug is causing untenable problems, and withdrawal of the drug isn't likely to be life threatening, then the drug should be discontinued. If after a reasonable time the condition abates, then a re-challenge with the drug should be done. If the unpleasant condition returns than a judgement must be made whether to continue to tolerate the drug's side effects to get the benefits, or to permanently terminate the drug.
Re: Ed With Zocor
Oct 30, 2004
[QUOTE=jeankb]My husband suddenly developed ED after being on 40 mg of zocor for 3 weeks. He wanted me to ask if anyone else had experienced this and if so, did you find a remedy.[/QUOTE]

Yes.... ED is definitely a side effect of all statins, not just Zocor. But it is right in the Zocor patient - package insert:
[U]Clinical Adverse Experiences[/U]
Reproductive: gynecomastia, loss of libido, erectile dysfunction.
Re: Ed With Zocor
Nov 15, 2004
are there other medicines that work on high cholesterol besides statins
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=jeankb]are there other medicines that work on high cholesterol besides statins[/QUOTE] There are lots of recommendations on this board and a few others I've come across: cinnamon, Omega 3 EFA's, blueberries, capsicum [cayenne pepper], Guggul, Policosanol and red yeast rice [natural statin]. These are all natural alternatives to prescription meds.
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=heart44]Yes.... ED is definitely a side effect of all statins, not just Zocor. But it is right in the Zocor patient - package insert:
[U]Clinical Adverse Experiences[/U]
Reproductive: gynecomastia, loss of libido, erectile dysfunction.[/QUOTE]

"Definitely a side effect" :rolleyes: You make it sound like it's a SIGNIFICANT ONE ..hardly. You'll find ED listed (in the insert) as a side effect for just about EVERY drug out there....standard "Boiler Plate" lingo to cover legal issues. In fact, you'll see just about EVERY conceivable side effect listed for most drugs on the inserts. There is absolutely NO BASIS for statins causing ED (as opposed to say Beta blockers, which can cause ED).
Re: Ed With Zocor
Nov 15, 2004
Well, I can see where there might be a basis for statins causing ED. It has to do with hormones. Cholesterol is needed to make sex hormones, and if the cholesterol is lowered too much, it can have a negative impact on the level of these hormones. It makes sense to me.
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=ARIZONA73]Well, I can see where there might be a basis for statins causing ED. It has to do with hormones. Cholesterol is needed to make sex hormones, and if the cholesterol is lowered too much, it can have a negative impact on the level of these hormones. It makes sense to me.[/QUOTE]

Show me one study that links low cholesterol that a statin would give (total 140 on the lower end) to hormone deficiency. Secondly, LOW hormone level alone does not cause ED..it effects LIBIDO.
Re: Ed With Zocor
Nov 15, 2004
I don't think this is exactly rocket science. I mean, if you significantly reduce cholesterol, which is required for the manufacture of sex hormones, then it stands to reason that the level of these hormones may also be impacted. As for low libido and ED? Well, one can certainly effect the other. How low of a cholesterol level is too low? Who knows? Everybody is different. I don't think you can rubber stamp everyone with a set value.
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=ARIZONA73]I don't think this is exactly rocket science. I mean, if you significantly reduce cholesterol, which is required for the manufacture of sex hormones, then it stands to reason that the level of these hormones may also be impacted.[/QUOTE]

That's not very good scientific reasoning. Just because cholesterol is required to produce hormones, it doesn't stand to reason that lowering the level of TOTAL cholesterol will result in less hormone. What component of TOTAL cholesterol is responsible for hormone production? Statins focus on LDL reduction...is LDL a major component of hormone production? I think not :D
Re: Ed With Zocor
Nov 15, 2004
Well alright. You just point me to a study which proves beyond any reasonable doubt that significant cholesterol reduction cannot possibly result in lower levels of sex hormones.
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=ARIZONA73]Well alright. You just point me to a study which proves beyond any reasonable doubt that significant cholesterol reduction cannot possibly result in lower levels of sex hormones.[/QUOTE]

No dice :) ..You made the claim ..now prove it.
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=rahod]Show me one study that links low cholesterol that a statin would give (total 140 on the lower end) to hormone deficiency. Secondly, LOW hormone level alone does not cause ED..it effects LIBIDO.[/QUOTE]
STUDY: E Bruckert et al. Men treated with hyoplipidaemic drugs complain more frequently of erectile dysfunction.
J Clin Pharm Ther 1996 21: 89-94.

RESULTS:
* Case reports linked both fibrates and statins with erectile dysfunction in a small number of men.
* Data from randomised clinical trials showed no difference between simvastatin and placebo in the 4S study (37/1814 on simvastatin, 28 of 1803 on placebo), but erectile dysfunction was not reported in other randomised trials.
* One case-control study looked at the prevalence of erectile dysfunction in 339 patients attending a lipid clinic with matched controls. Both fibrates and statins were independent predictors of erectile dysfunction with odds ratios of about 1.5.
* Regulatory agencies in Australia and the UK had yellow card reports of erectile dysfunction in men on lipid lowering drugs, both fibrates and statins. * In a small number of men, withdrawal of the lipid-lowering drug and rechallenge resulted in recurrent symptoms, though usually not a blind rechallenge.
* One useful observation was that drug switching resolved the problem in a number of cases.



[list]
[/list]
Re: Ed With Zocor
Nov 15, 2004
[QUOTE=heart44]STUDY: E Bruckert et al. Men treated with hyoplipidaemic drugs complain more frequently of erectile dysfunction.
J Clin Pharm Ther 1996 21: 89-94.

RESULTS:
* Case reports linked both fibrates and statins with erectile dysfunction in a [B]small number [/B] of men.
* [B]Data from randomised clinical trials showed no difference between simvastatin and placebo [/B] in the 4S study (37/1814 on simvastatin, 28 of 1803 on placebo), but erectile dysfunction was not reported in other randomised trials.
* One case-control study looked at the prevalence of erectile dysfunction in 339 patients attending a lipid clinic with matched controls. Both fibrates and statins were independent predictors of erectile dysfunction with odds ratios of about 1.5.
* Regulatory agencies in Australia and the UK had yellow card reports of erectile dysfunction in men on lipid lowering drugs, both fibrates and statins. * In a small number of men, withdrawal of the lipid-lowering drug and rechallenge resulted in recurrent symptoms, [B]though usually not a blind rechallenge.[/B]* One useful observation was that [B]drug switching resolved the problem in a number of cases. [/B]


[list]
[/list][/QUOTE]

Doesn't look like much to me...READ THE [B]BOLD [/B] PRINT
Re: Ed With Zocor
Nov 16, 2004
Many people are under the illusion that LDL is merely just some wicked, evil substance which should be attacked with a vengeance by any means possible, with total disregard to the essential functions that it performs inside our bodies.

In his book "Controlling Cholesterol", doctor Kenneth H. Cooper stated the following in his discussion about LDL:

"LDLs are very rich in cholesterol. Much of the cholesterol in the bloodstream resides in these LDLs, and this cholesterol can be used in essential ways by various body tissues. For example, some of the LDLs are pulled out of the blood by receptors on the body's cells. The cholesterol in these LDLs then proceeds to play a vital role in the cell's membranes. In addition, LDL cholesterol is used in the production of steroid hormones in the adrenal glands and the sex organs, and it participates in the formation of bile acids in the liver."

So, is it possible for LDL to be lowered too much, to the extent that hormone levels can be adversely impacted? I would tend to think so. Lower isn't always necessarily better. Once you go beyond a certain point, there are bound to be consequences, especially when you are dealing with a substance which performs many essential bodily functions.
Re: Ed With Zocor
Nov 16, 2004
Case reports
Cases of ED were first reported after clofibrate. Those described by Schneider showed recovery after drug withdrawal and recurrence on rechallenge. Five reports identified seven cases of ED following gemfibrozil. Rechallenge confirmed the effect in two. Therapy with bezafibrate was without adverse effect in three of these patients, but clofibrate had a similar effect in one.

ED in association with statins was first reported by Halkin et al. where both lovastatin and pravastatin separately caused ED in a 57-year-old man. Jackson reported five cases of ED with simvastatin at doses of 10 and 20 mg. Sexual function was restored within 1 week of stopping the drug. Two patients were rechallenged and impotence recurred. Alternative lipid-lowering therapies (fluvastatin or fenofibrate) did not cause this effect in these patients.

Information from regulatory agencies
The Australian Adverse Drug Reaction Advisory Committee (ADRAC) reports 11 cases of ED due to clofibrate, six due to gemfibrozil and 42 cases of ED in association with simvastatin. The men affected by simvastatin ranged in age from 43 to 72 years (median 57) and the onset occurred from 48 hours to 27 months (median 6 weeks) after the drug was started. Simvastatin was the only drug implicated in 35 of the reports and, in four rechallenged, the symptom recurred. Of the 29 reports in which recovery was mentioned, 14 had recovered after discontinuing the drug whereas in the other 15 there had been no recovery at the time the report was submitted. ADRAC also lists 11 reports of gynaecomastia in association with simvastatin.

Statins inhibit the rate-limiting step of cholesterol synthesis (HMG-CoA reductase) and hence potentially may inhibit the synthesis of steroid hormones derived from cholesterol, including tetosterone. There is evidence that simvastatin causes minor changes in circulating androgen concentrations in asymptomatic men.
Re: Ed With Zocor
Nov 17, 2004
thank you all for your replys - husband has been taking half a pill of zocor daily (instead of 40 mg he is taking 20 mg) his cholesterol was 136 after taking 40mg for 6 weeks -it will be interesting to see next blood test - but the ED is not as much a problem now and his state of mind is much improved because of it - meanwhile he has been exercising and losing weight also. He has been thru many test to see if he had any nerve or blood vessel damage and test were negative so I believe it was the zocor unless there is some recovery time after going from a very high TC and high trigs to normal levels - any thoughts on that---





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