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High Cholesterol Message Board


High Cholesterol Board Index


I've been reading more and more articles about a sugar-cane derivative called Policosanol that (in studies at least) has shown a very good ability to lower cholesterol, but more importantly, improve the good to bad cholesterol ratio. It is said to give similar results to some of the statins - but with fewer side effects such as muscle pain and weakness, rhabdomyolisis, or neuropathies.

10-20mg/day is the recommended dose - some studies have shown that above 20mg, the incremental improvement drops off significantly.

Here are some quotes from information on various web sites:

"A 2002 analysis in the American Heart Journal reviewed more than 60 clinical trials of sugar cane-derived policosanol that involved more than 3000 patients. The authors concluded that policosanol is "a very promising phytochemical alternative to classic lipid-llowering agents such as statins.""

"One study showed that patients taking the standard daily 10 mg dose of policosanol experienced a 17% drop in total cholesterol, a 25.6% drop in LDL cholesterol, and a 28.4% rise in HDL cholesterol. These percentages are equal to results obtained with statin medications."

"This randomized, double-blind study investigated the cholesterol-lowering efficacy and tolerability of policosanol 20 mg/day compared with 40 mg/day. Changes in low-density lipoprotein (LDL)-cholesterol levels were predefined as the primary efficacy endpoint. Patients with type II hypercholesterolemia were enrolled in the study and instructed to continue a step I cholesterol-lowering diet for 6 weeks and those eligible to be included (89) were randomly allocated to receive under double-blind conditions placebo (n = 30), policosanol 20 mg/day (n = 29) or 40 mg/day (n = 30). After 24 weeks, policosanol at 20 and 40 mg/day significantly (p < 0.00001) lowered LDL-cholesterol by 27.4% and 28.1%, total cholesterol (p < 0.00001) by 15.6% and 17.3%, and the LDL-cholesterol/high-density lipoprotein (HDL)-cholesterol ratio by 37.2% and 36.5%, respectively The ratio of total cholesterol/HDL-cholesterol was lowered by 27.1% and 27.5%, while HDL-cholesterol levels increased (p < 0.001) by 17.6% and 17.0%, respectively."


I'm a natural born skeptic when it comes to things I put in my body - so I was wondering if anyone knows more about this supplement, or has any personal experience with it.

I'm tempted to order some of this from my normal online vitamin site to see what effect it has for me...

HubbleRules





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