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High Cholesterol Message Board


High Cholesterol Board Index


ARIZONA,
So then you are saying that even if one applies the postulates of Pauling and it is effective, there will be no lowering of Lp(a) and thus no measure of effectiveness of treatment...other than at autopsy! Then it becomes a case of "yah gotta BELIEVE." When that becomes the premise I start hearing duck noises in my head. All my "believing" went down the toilet when Atkins heart stopped the first time!
BTW, I've taken 1-2 grams of vitamin C a day for 40 years! It's only the last year that I've become absolutely convinced that Pauling took me (and himself) for a ride. Oh and my protein shake conains 1.3g L-proline and 1.6 g. L-Lysine, so I'm using the supplement by a back door mechanism!

(I have read that alcohol is probably the only agent that can possibly lower Lp(a)...I am working the premise and should know in a month.)

I also read that high Lp(a) is most damamging in the presence of a high LDL. THAT, I've got fully controlled...I haven't been over 90 in many years. I will have to tell my sister to have hers checked and see if she inherited the taint also (which I think resides on a DOMINANT gene...alas!)
Demographically, my mther's roots are Ukrainian but my Lp(a) seems to match those typically found in SUDAN :D:D:D (Japanese average about 7.0!!!!!!!!)

Do you know anything about the relationship between Lp(a) and apo A-1 (and or apo-B?)
Here's another, ARIZONA, and it fits me to a tee...I am a classic "quit booze for 3 months" type:
[quote]The effect of alcohol withdrawal on serum concentrations of Lp(a), apolipoproteins A-1 and B, and lipids.

Huang CM, Elin RJ, Ruddel M, Schmitz J, Linnoila M.

Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892.

Moderate alcohol consumption is associated with a decreased risk of coronary artery disease. The mechanism of the putative protective effect of alcohol intake, however, remains elusive. Recent studies suggest that a ratio of apolipoprotein A-I/apolipoprotein B and Lp(a) are better indicators of the risk of atherosclerosis than total cholesterol and high density lipoprotein cholesterol. To assess the effect of alcohol on these analytes, we determined the concentration of Lp(a), apolipoprotein A-I, apolipoprotein B, total cholesterol, and high-density lipoprotein cholesterol, and calculated low-density lipoprotein cholesterol in serum of 12 patients meeting DSM-III-R criteria for alcohol dependence at the time of admission for treatment of alcohol withdrawal (before). The analyses were repeated after 4 weeks of supervised abstinence on a locked research unit (after). With abstinence, there was a significant increase in the concentration of Lp(a), the atherogenic index and the ratio of low-density to high-density lipoprotein cholesterol but a significant decrease in total cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I, and the apolipoprotein A-I/B ratio. Apolipoprotein B and low-density lipoprotein cholesterol showed no significant changes before and after alcohol abstinence. Thus, decreased Lp(a) and increased high-density lipoprotein cholesterol and apolipoprotein A-I may be factors mediating the putative protective effect of alcohol in coronary artery disease.
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