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High Cholesterol Message Board


High Cholesterol Board Index


eagleheart,

I'm in the same boat but with Lp(a) of 50...which I thought was super-high.
I am getting a little luck with slo-niacin but I do only 500 mg./day. (with 20 mg. Lipitor)

I think the risk of 2 grams niacin and 40 mg. Lipitor is too risky.

If I were you, the FIRST thing I'd do is get a retest on the Lp(a)...If you have parents, ask them to test also because there's a high degree of familiarity with high Lp(a.)

I wish I could tell you something works, but I am against a stone wall with it. There is some evidence that it's evil is worked in the presence of a high LDL. Yours is the lowest I've ever seen...keep it there. That's the approach I am using.
I really think that continuing to keep your cholesterol as low as you have it will cause a reduction in your plaques and you will never need intervention.

My feelings about the megadosing with ascorbate, and a few extra amino acids is that they are a waste of money as a way of treating high Lp(a)...no studies have shown corroboration.

Alcohol and heavy exercise didn't budge my Lp(a)... only niacin to a slight extent was of any use. The literature is replete with references to only tow agents that lower Lp(a) niacin and estrogen...not so great for guys.

I think there will be more data on Lp(a) coming out of studies soon because it IS an independent risk factor of importance. I'll pass on anything I find.

This paragraph from the CLEVELAND CLINIC is informatiove:
[QUOTE]Prospective studies, on the other hand, present a slightly more complex picture. Some studies suggested Lp(a) is a strong, independent predictor of coronary heart disease, particularly in women and young men, while others found no such association. One recent prospective trial found that while Lp(a) did not independently increase coronary heart disease risk, it seemed to increase the risk of elevated total cholesterol, LDL-C, and apolipoprotein B (the major lipoprotein of the atherogenic lipids), and blunt the cardioprotective effect of high levels of HDL-C. Similarly, in a cohort of patients with premature coronary heart disease, Lp(a) was associated with extremely high relative risk only in the presence of elevated levels of total cholesterol or an increased ratio of total cholesterol/HDL-C. These interactive effects on risk were an order of magnitude greater than the impact of the lipid abnormalities alone. Another recent study of men with documented coronary heart disease and elevated levels of both LDL-C and Lp(a) found that Lp(a) seemed to lose its atherogenic potency once LDL-C was aggressively lowered.

Of note: No prospective clinical trial has been conducted in which the value of reducing elevated levels of Lp(a) has been confirmed.[/QUOTE]





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