I too agonized over taking statins. My TC went from 220 a year ago to 263 this year, even tho I exercise, eat right and took Cholest-off and niacin. When my dr. said she saw evidence of plaque in the arteries, she convinced me it's time for the statins--so I started Crestor two months ago and so far so good. I've had one follow-up blood test and get another in April.
For what its worth, my best friend has been on statins over 10 years and has never had a problem.
Thanks to the helpful people who post here, I'm also taking CoQ10. My dr. never mentioned that statins can deplete this in our bodies.