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High Cholesterol Message Board

High Cholesterol Board Index

My doctor prescribed me Zetia due to elevated ALT levels and other issues with Crestor 5 mg. I had tried Niaspan but the flushing was bad. I went to pick up the Zetia today and was talking to my pharmacist. He asked me about my Total:HDL ratio which is approx. 6.5:1 (my total is 252 and HDL is 39). He said it would likely be easier for me to raise my HDL so I'm going to give the Niaspan (prescription grade Niaspan) another shot. The suggestion is to take it at night or with evening meal. Is anyone taking Niaspan/Niacin during the day (earlier)? If so, how is it going? Also, does anyone take Niaspan/Niacin along with Zetia or Policosanol? Again, if so, how are they performing for you?

Thanks for the reply. Niaspan is supposed to be time released and is the sole prescription form of Niacin in the US. Still, I find it very intense at 1000 mg.
since you flushed with NIASPAN at 1000 mg., why not instead try the hexanicotinoate or, as I do, a SLOW ACTING OTC formulation like SLO NIACIN, made up of teeny polygel encapsulated particles that dissolve slowly.
Both alternatives as FAR cheaper than the overpriced NIASPAN...and don't be fooled by the fact that Niaspan is "prescription"'s just another extended release formulation designed to mitigate flushing.

The regimen for me that reduced flushing to zero is to take my SLO-NIACIN (Upsher-Smith) just before bedtime with 2 aspirin and my Lipitor. THat way if there is any flushing, I'm asleep for the event.

Aspirin helps A LOT!

I don't think policosanol is of much proven use for lipid control...a single study with 120 diabetics taken it is just not enough evidence. But it's cheap and safe so everyone can try it on his own and see for himself.

Niacin in any formulation is very apt to raise ALT.

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