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Niacin Studies
Oct 15, 2006
Can anyone point me towards studies involving Niacin (ESPECIALLY SLO-NIACIN) and its effectiveness in lowering ldl, total and increasing hdl? I chanced upon one study at the University of Washington concerning Slo-Niacin and Simvastatin but it appears to ongoing (or I can't figure out the results:confused: .

I tried Niaspan which is considered extended release, but the flushing was so bad (at 1000 mg). I felt my head and shoulders were going to explode. The slo-niacin is not as bad but I haven't checked my labs with it yet (been taking 500 mg x 2 for about 4 weeks now). My big concerns are effectiveness and liver toxicity.

Thanks for any advise or info that anyone can give me.
Re: Niacin Studies
Oct 23, 2006
Lenin,

I received the Slo-Niacin Monograph and the studies today. I can summarize fairly quickly but you may want to obtain them so that you can get more specifics (and give a better analysis than this C Biology student :) . Basically, as stated in Niacin for Lipid Disorders by W. Virgil Brown, MD (of Emory University), he notes that most patients tolerate sustained-release Niacin at doses of 2 g/day and Slo-Niacin (or other time released Niacin) has no more adverse effects than Niacin (at up to 12 grams/day) and gives equivalent efficacy in lowering LDL. One study at Mayo Clinic was most interesting to me; Low-Dose, Time-Release Nicotonic Acid: Effects in Selected Patients with Low Concentrations of High-Density Lipoprotein Cholesterol by Ray W. Squires, Phd (and others). In it, 63 participants in a cardiology program (rehabilitation-preventive) with a mean HDL of 34 and total of 223 were treated with low-dose, time release niacin (mean of 1,297 mg/day for a duration of 7.4 months. For the group, HDL increased a mean of 18%, total decreased 9% and triglycerides decreased 20%, among others. Of particular significance to you and I, at this mean level, uric acid concentrations were minimally increased. Also, that article mentions a study by Luria which studied 32 persons with a mean HDL of 39 and total of 232. The subjects were given 1000 mg/day of time released Niacin (my present dose :). The HDL was increased to 28% (up to 50) but total was not affected by the treatment.
The Brown study does mention gallbladder disease as a side effect of Niacin therapy??? Speaking of which, can you dig out that gall bladder flush recipe of yours? I'm thinking of doing it this weekend.
Re: Niacin Studies
Oct 24, 2006
Thanks judge,

That encourages me to up my dosage to 750 g. starting tonight.
I HATE lines like:
[QUOTE]The HDL was increased to 28% (up to 50) but total was not affected by the treatment. [/QUOTE]
It's so cheesy, like the "200 particpants in the Whiz-Bang Diet lost 'up to 150 pounds' in 6 months"...but (never mentioned is that the MEDIAN person gained 2 pounds.)

"UP TO" should be banned in any discussion of results, it is the stuff of car-salesman... "this car should last "up to 20 years.";) I feel similar about "mean values" and much prefer median values. Say there are 10 people in a poor village making $10,000/ per year with one making a million...the village is extraordinary rich with its mean income over $100 thousand a year, but poor for the median income earner of $10 thousand.

I was heartened by the absence of problems with dosages up to 12 grams.

Did the monograph say anything about concurrent use of statins?

I'd LOVE to see the breakdown of HDL improvement with doseage...perhaps, like statins, the largest marginal effects occur at the lower doseages.

Judge,

I'll post my method for the gall bladder flush on the Liver Disorders forum now.
Re: Niacin Studies
Oct 24, 2006
Lenin,

Remember that the 12 gram result is with regular Niacin! There are 2 studies in the Monograph regarding Combination therapy.

1. 29 participants (whose baseline LDL was 215) took 500 mg Niacin (Slo-Niacin 1 g x 2/day was rotated after 12 months for 8 months x2) x 4/day with lovastatin 20mg/day and colestipol 10 g x 2/day. No clinical significant differences were noted between the Slo-Niacin and regular Niacin regimens in terms of uric acid, glucose, insulin or asparate levels. Basically, the results were +22% HDL, -39% Triglycerides, -54% LDL. The target LDL of 100 mg/dl was achieved at 8 months by those receiving the combo (with Slo-Niacin) while it was achieved by 52% by those who used regular Niacin.

2. The other was a 3 yr study involving 160 patients with extablished coronary disease and low HDL. There were 4 groups; Simvastatin + Niacin, Antioxidant Vitamins, Simvaastatin/Niacin and Antioxidant Vitamins, All Placebos.The winner was,:wave: drumroll please, Simvastatin and Niacin with -42%LDL, +26 % HDL, -36% TG, although the combo with Antioxidant
vitamins achieved -15% of Lp(a). Also, the Antioxidant vitamins alone caused tryglicerides to increase by 36% but in combo with the statin and Niacin TGs went down a bit over 30%.

So, it would appear that combining the Niacin with the statin definitely has a drastic effect on the labs.
Re: Niacin Studies
Oct 24, 2006
[QUOTE=judgejkh]Can anyone point me towards studies involving Niacin (ESPECIALLY SLO-NIACIN) and its effectiveness in lowering ldl, total and increasing hdl? I chanced upon one study at the University of Washington concerning Slo-Niacin and Simvastatin but it appears to ongoing (or I can't figure out the results:confused: .

I tried Niaspan which is considered extended release, but the flushing was so bad (at 1000 mg). I felt my head and shoulders were going to explode. The slo-niacin is not as bad but I haven't checked my labs with it yet (been taking 500 mg x 2 for about 4 weeks now). My big concerns are effectiveness and liver toxicity.

Thanks for any advise or info that anyone can give me.[/QUOTE]

Look for NO FLUSH Niacin that elimates those hot flashes. You ca find thes at most health food stores.

I've used it with NO fLUSHING FOR A LONG PERIOD OF TIME.
Re: Niacin Studies
Jan 22, 2007
I am very happy with time-release formulations at 500 mg. I have TRIED several times to take the No-Flush at a dosage of 1000 mg. and find the flush to be too much to bear on a daily basis.

So although, claims can probaly be honestly made that "most people can take 2,000 mg. Slo-Niacin (in whatever form) without discomfort", those "most people" don't include me. :D

So, I am/must be content with tolerable HDL upping of niacin that I get with 500 mg....somewhere between +5 and +8 mg./dL. After all 40 is a lot better than 35...or the miserable 28 before the Lipitor.
Re: Niacin Studies
Jan 22, 2007
Lenin (and anyone else),

I'm considering trying a bottle of the 750 mg Slo-Niacin for 60 days. Do you think it's too much (coupled with the Vytorin 10/20)? The literature seems to indicate that one shouldn't take > 1 gram with statin. I was thrilled when my HDL hit 42 with the Vytorin 10/20 and 500 mg Slo-Niacin:blob_fire . I visited my retina specialist this past friday for my 6 month check-up (detached retina with sclaria buckle repair in 1997:mad: ). Anyway, he was a family physician b4 specializing in retina diseases. We were discussing cholesterol drugs (I have started the vytorin since my last visit with him) and he point blank said that his biggest concern was the pharmacy companies will to make profits, at any cost. It was refreshing to hear a doctor with concern with statins (he had a bad experience himself while on Zocor) and I guess that's why we're on here trying to look out for one another:wave: . If anything, this board causes me to proceed rather cautiously:cool: .

I'm glad you dug this thread out of the vault. It is motivating to try and increase my HDL even further before my next labs in April.
Re: Niacin Studies
Jan 23, 2007
Judge,

Actually I DIDN'T dig up this old thread, JohhnyO did.

I tried the 750 mg. for a couple days and noticed that I was flushing if I didn't go to sleep immediately after taking it. Flushing frightens me since it seems to oftentrigger bouts of seborrheic dermatitis that persists for several days...which I HATE! So I went back to 500 mg. (currently Dixon's TIME RELEASED NIACIN that I found a dozen bottles of in a bargain bin.)

Cholestipol is a resin that acts as a bile acid sequestrant...it attaches to the cholesterol in bile and prevents it's resorption so you excrete it. Your liver searches for more cholesterol to make more bile and pulls it out of the blood, thus lowering it. It's more innocuous than the ezetimibe in the Vytorin.

Try the 750 or 1000 mg. SLO-NIACIN and after a month or two see how your liver enzymes (and HDL) look.
Re: Niacin Studies
Jan 23, 2007
Thanks Connie. It was a great article about the ability of Niacin to boost HDL and showed some of the ongoing work with Niacin, including Merck's development, which I had read a bit about a while back. To me, it helps me know that Slo-Niacin is right for me because the Dr. Brown that the article refers to has done studies with Slo-Niacin in combination with Statins, by itself, etc. in the past. If anyone is interested, the manufacturer of Slo-Niacin has a monograph with various studies using Niacin (and Slo-Niacin). If interested, just check one of my earlier posts in this thread.
Re: Niacin Studies
Jan 24, 2007
:blob_fire :blob_fire :blob_fire :blob_fire :blob_fire :blob_fire

That's about as close as I can come to explaining how it felt when I worked my way from 500 mg to 1000 mg of Niaspan!

In all seriousness, I am very thankful to Lenin, the former spokesperson for Slo Niacin:D, for introducing me to a much more tolerable form of Niacin. It (500 mg) is much less harsh in terms of the flushing and the impact on my hdl (coupled with the vytorin 10/20) has been fantastic.





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