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A good study reported in the NIH.gov publication.
[QUOTE]METHODS: Ninety-eight patients on aspirin (160 mg/day) for at least one month were enrolled. Aspirin resistance was measured by the platelet function analyzer (PFA)-100 analyzer; genotyping of the three polymorphisms was performed using a polymerase chain reaction-based restriction fragment-length polymorphism analysis. RESULTS: Using a collagen/epinephrine-coated cartridge on the PFA-100, the prevalence of aspirin resistance was 29.6% (n = 29). Aspirin-resistant patients were significantly more often Pl(A1/A1) (86.2%; n = 25) than sensitive patients (59.4%; n = 41; p = 0.01). Of the 29 patients, 25 were reevaluated after having taken 300 mg/day aspirin for at least one month. Only 11 patients still have nonprolonged collagen epinephrine closure time, and these were all Pl(A1/A1).[/QUOTE]

What this is saying is that of the 98 chosen to receive 160 mg. aspirin, 29 remained "quick platelet clotters" and thus remained unprotected against heart attack. When 25 of these 29 were increased to 300 mg. per day, 18 of them had their platelets revert to "unsticky" leaving 11 of them still unprotected against quick clotting.

Two conclusions that one might well draw from this:
1. Those taking LESS than 160 mg./day will have MORE than 29% unprotected
2. Those taking MORE than 300 mg./day will have LESS than 11% unprotected.

This study alone makes me feel confidant that taking 650 mg./day is a good idea unless one can have platelets tested for stickiness to determine personally whether one is protected by 81mg./day. It looks, from this data, that protection might be a somewhat 50-50 proposition. Not good enough for me.

Then when you add on top of that the fact that aspirin in reasonably high doses is probably the best inflammatory agent ever discovered with the possible exception of the far more dangerous cortisone, then the cards come down good for taking a dose of 650 mg. or even higher if one's stomach can take it. I do 650 mg. because I have enough heart disease to warrant a stent.

I get the willies when I hear about doctors being super-scrupulous in recommending a teeny dose aspirin and then adding Plavix, a really dangerous drug in my estimation, to make sure than one is preventing platelet clumping. That to me seems really nutsy thinking.

aspirin at JACK'S $.99 STORE in Manhattan...a bottle of 250 regular strength (325 mg.) for $.99 a bottle>
Thanks for the info Lenin.

I'm going to at least double my doseage from here on in. I'll probably take one tablet in the morning and one around dinner time. That will bring me up to 160...

I've had stomach upset in the past from regular aspirin when I took it for an extended period. I'll stick with the 81mg enteric coated and just double or triple up on my doseage.

HubbleRules
:cool:
[QUOTE=HubbleRules]Thanks for the info Lenin.

I'm going to at least double my doseage from here on in. I'll probably take one tablet in the morning and one around dinner time. That will bring me up to 160...

I've had stomach upset in the past from regular aspirin when I took it for an extended period. I'll stick with the 81mg enteric coated and just double or triple up on my doseage.

HubbleRules
:cool:[/QUOTE]

This sounds like a good plan....I'm wondering if it would cause more ringing in the ears-which I already have? I do take 81 mg of the coated aspirin now. I'm sure taking more would help my ongoing muscle pain...which is slowly getting better I think.





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