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High Cholesterol Message Board


High Cholesterol Board Index


Re: Types of niacin
Jan 27, 2007
Tina,


I think it would be more effective for you to take the 4 pills at one time. THat would give you a more effective anti-cholesterol walllop while minimizing the time your liver is exposed to niacin.

Basically, the terminology (slow release, sustained, long acting) differences are a gray area that represent different rates at which the niacin is absorbed. Most actually use nicotinic acid in various formulations to slow down delivery and thus mitigate flushing. The stuff sold as "flush free" can be one of these or else, more commonly inositol hexanicotinoate where the nicotinic acid molecules are slowly peeled off the inolsitol portion of the molecule.

THen there's the prescription version sold as "extended release" called NIASPAN. Same nicotinic acid time release but at a MUCH higher price.

Thinking is that straight stuff in high doses (like 2 grams) is best for cholesterol and liver but causes huge flushing problems. I don't know ANYONE who can take 2 grams straight-up without major flushing so most of us take some sort of time release formulation in much smaller dosages.
Re: Types of niacin
Jan 27, 2007
[QUOTE=Lenin;2766508]Tina,

I think it would be more effective for you to take the 4 pills at one time. THat would give you a more effective anti-cholesterol walllop while minimizing the time your liver is exposed to niacin.

Thinking is that straight stuff in high doses (like 2 grams) is best for cholesterol and liver but causes huge flushing problems. I don't know ANYONE who can take 2 grams straight-up without major flushing so most of us take some sort of time release formulation in much smaller dosages.[/QUOTE]

Lenin, I guess my spreading my dose out to 4xs a day for a total of 800mg was just my DIY, cheap-skate form of time-release! I increased my dose incrementally so that my body could adjust and hopefully avoid the flushing. But, it seems I should continue to increase the dose to 2g.

Is the flush-free formulation the one that has been shown to be much less effective? I was wondering which to avoid. Many years ago I read that timed release formulations of vitamins and also prescription drugs could not equal the continual slow dose of a manual approach. If the timed-release version is as effective as plain niacin I will switch to that for simplicity's sake.

Many thanks, Tina





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